Molecularly imprinted polymer decorated 3D-framework of functionalized multi-walled carbon nanotubes for ultrasensitive electrochemical sensing of Norfloxacin in pharmaceutical formulations and rat plasma

[Display omitted] •Molecularly imprinted polymer decorated 3D-framework of fMWCNTs was synthesis.•Fabricated electrochemical sensors were applied for Norfloxacin determination in pharmaceutical formulations and rat plasma.•The sensors show low detection-limit, wide linear-range and high selectivity...

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Veröffentlicht in:Sensors and actuators. B, Chemical Chemical, 2019-06, Vol.288, p.363-372
Hauptverfasser: Liu, Zhenping, Jin, Mingliang, Lu, Han, Yao, Jiyuan, Wang, Xin, Zhou, Guofu, Shui, Lingling
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container_title Sensors and actuators. B, Chemical
container_volume 288
creator Liu, Zhenping
Jin, Mingliang
Lu, Han
Yao, Jiyuan
Wang, Xin
Zhou, Guofu
Shui, Lingling
description [Display omitted] •Molecularly imprinted polymer decorated 3D-framework of fMWCNTs was synthesis.•Fabricated electrochemical sensors were applied for Norfloxacin determination in pharmaceutical formulations and rat plasma.•The sensors show low detection-limit, wide linear-range and high selectivity for Norfloxacin detection. In this work, a 3D-framework of functionalized multi-walled carbon nanotubes (fMWCNTs) decorated with molecularly imprinted polymer (MIP), has been fabricated to achieve fast and ultrasensitive electrochemical molecular sensing. The cavity networks of MIP layer from Norfloxacin (NFX) molecules offers simultaneous identification and quantification of NFX; and thus, ensures its high selectivity. The porous structure of fMWCNT 3D-framwork effectively increases the specific surface area, and the copolymer of fMWCNTs and MIP shows synergistic effect for electrocatalytic reaction of NFX at the modified sensor. Under optimized conditions, the fabricated sensors show wide linear detection ranges of 0.003-0.391 μM and 0.391–3.125 μM, low limit of determination (LOD) of 1.58 nM, and excellent selectivity in discriminating NFX according to its structural analogues and possible interferences. Precise and fast quantification of NFX in pharmaceutical formulations (Yunnan Baiyao and Ouyi Pharmaceutical) and rat plasma samples (N = 4) suggests its simplicity and reliability. The recoveries from pharmaceutical formulations ranged from 97.36 to 109.58% with the precisions (relative standard deviations, RSD, n = 3) of 1.74–3.41%; and the recoveries from rat plasma samples ranged from 83.00 to 115.67% with RSDs (n = 3) of 0.45–10.30%. Considering the advantages of easy fabrication, and selective and sensitive detection, such sensors with different types of MIPs would be widely applied in the fields of pharmaceutical analysis, and environmental and clinical therapeutic drug monitoring.
doi_str_mv 10.1016/j.snb.2019.02.097
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In this work, a 3D-framework of functionalized multi-walled carbon nanotubes (fMWCNTs) decorated with molecularly imprinted polymer (MIP), has been fabricated to achieve fast and ultrasensitive electrochemical molecular sensing. The cavity networks of MIP layer from Norfloxacin (NFX) molecules offers simultaneous identification and quantification of NFX; and thus, ensures its high selectivity. The porous structure of fMWCNT 3D-framwork effectively increases the specific surface area, and the copolymer of fMWCNTs and MIP shows synergistic effect for electrocatalytic reaction of NFX at the modified sensor. Under optimized conditions, the fabricated sensors show wide linear detection ranges of 0.003-0.391 μM and 0.391–3.125 μM, low limit of determination (LOD) of 1.58 nM, and excellent selectivity in discriminating NFX according to its structural analogues and possible interferences. Precise and fast quantification of NFX in pharmaceutical formulations (Yunnan Baiyao and Ouyi Pharmaceutical) and rat plasma samples (N = 4) suggests its simplicity and reliability. The recoveries from pharmaceutical formulations ranged from 97.36 to 109.58% with the precisions (relative standard deviations, RSD, n = 3) of 1.74–3.41%; and the recoveries from rat plasma samples ranged from 83.00 to 115.67% with RSDs (n = 3) of 0.45–10.30%. 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B, Chemical</title><description>[Display omitted] •Molecularly imprinted polymer decorated 3D-framework of fMWCNTs was synthesis.•Fabricated electrochemical sensors were applied for Norfloxacin determination in pharmaceutical formulations and rat plasma.•The sensors show low detection-limit, wide linear-range and high selectivity for Norfloxacin detection. In this work, a 3D-framework of functionalized multi-walled carbon nanotubes (fMWCNTs) decorated with molecularly imprinted polymer (MIP), has been fabricated to achieve fast and ultrasensitive electrochemical molecular sensing. The cavity networks of MIP layer from Norfloxacin (NFX) molecules offers simultaneous identification and quantification of NFX; and thus, ensures its high selectivity. The porous structure of fMWCNT 3D-framwork effectively increases the specific surface area, and the copolymer of fMWCNTs and MIP shows synergistic effect for electrocatalytic reaction of NFX at the modified sensor. Under optimized conditions, the fabricated sensors show wide linear detection ranges of 0.003-0.391 μM and 0.391–3.125 μM, low limit of determination (LOD) of 1.58 nM, and excellent selectivity in discriminating NFX according to its structural analogues and possible interferences. Precise and fast quantification of NFX in pharmaceutical formulations (Yunnan Baiyao and Ouyi Pharmaceutical) and rat plasma samples (N = 4) suggests its simplicity and reliability. The recoveries from pharmaceutical formulations ranged from 97.36 to 109.58% with the precisions (relative standard deviations, RSD, n = 3) of 1.74–3.41%; and the recoveries from rat plasma samples ranged from 83.00 to 115.67% with RSDs (n = 3) of 0.45–10.30%. Considering the advantages of easy fabrication, and selective and sensitive detection, such sensors with different types of MIPs would be widely applied in the fields of pharmaceutical analysis, and environmental and clinical therapeutic drug monitoring.</description><subject>3D-framework</subject><subject>Carbon nanotubes</subject><subject>Electrochemical sensor</subject><subject>Formulations</subject><subject>Molecularly imprinted polymer</subject><subject>Multi wall carbon nanotubes</subject><subject>Norfloxacin</subject><subject>Pharmaceuticals</subject><subject>Polymers</subject><subject>Selectivity</subject><subject>Sensors</subject><subject>Synergistic effect</subject><issn>0925-4005</issn><issn>1873-3077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9UduO1SAUbYwmHkc_wDcSn1splF7ikxmvyYy-6DOhm43DkUIFOuPxG_0o6Zx5NiEhsNdlZ62qetnSpqVt__rYJD83jLZTQ1lDp-FRdWjHgdecDsPj6kAnJuqOUvG0epbSkVLa8Z4eqr_XwSFsTkV3InZZo_UZNVmDOy0YiUYIUe0__F1tolrwLsSfJBhiNg_ZBq-c_VPGy-ayre-Uc-UBKs7BE698yNuMiZgQSQFEldAnm-0tEiy2OQa4wcWCcuR-4n_s0l9CNC78VmA9KWe9UXFRgFu-BxatYqZ270SU16TsR1an0qKeV0-McglfPNwX1fcP779dfqqvvn78fPn2qgbes1ybeZx7LdDMwMzMOhhFz4XuZ2E6HLlWLe8A-okKGKATQmvQqPnIhplx6Ay_qF6dddcYfm2YsjyGLZYokmSMtcM0iqkvqPaMghhSimhkSXdR8SRbKvfS5FGW0uRemqRMltIK582Zg2X9W4tRJrDoAbWNJS-pg_0P-x8ZBqgC</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Liu, Zhenping</creator><creator>Jin, Mingliang</creator><creator>Lu, Han</creator><creator>Yao, Jiyuan</creator><creator>Wang, Xin</creator><creator>Zhou, Guofu</creator><creator>Shui, Lingling</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0001-5976-1355</orcidid></search><sort><creationdate>20190601</creationdate><title>Molecularly imprinted polymer decorated 3D-framework of functionalized multi-walled carbon nanotubes for ultrasensitive electrochemical sensing of Norfloxacin in pharmaceutical formulations and rat plasma</title><author>Liu, Zhenping ; Jin, Mingliang ; Lu, Han ; Yao, Jiyuan ; Wang, Xin ; Zhou, Guofu ; Shui, Lingling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-fb8b6d5efbc2fb24c85635d6b5f4e83da134cc6905c7c455ddcded3827b23c4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>3D-framework</topic><topic>Carbon nanotubes</topic><topic>Electrochemical sensor</topic><topic>Formulations</topic><topic>Molecularly imprinted polymer</topic><topic>Multi wall carbon nanotubes</topic><topic>Norfloxacin</topic><topic>Pharmaceuticals</topic><topic>Polymers</topic><topic>Selectivity</topic><topic>Sensors</topic><topic>Synergistic effect</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Zhenping</creatorcontrib><creatorcontrib>Jin, Mingliang</creatorcontrib><creatorcontrib>Lu, Han</creatorcontrib><creatorcontrib>Yao, Jiyuan</creatorcontrib><creatorcontrib>Wang, Xin</creatorcontrib><creatorcontrib>Zhou, Guofu</creatorcontrib><creatorcontrib>Shui, Lingling</creatorcontrib><collection>CrossRef</collection><collection>Electronics &amp; Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical &amp; Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Sensors and actuators. B, Chemical</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Zhenping</au><au>Jin, Mingliang</au><au>Lu, Han</au><au>Yao, Jiyuan</au><au>Wang, Xin</au><au>Zhou, Guofu</au><au>Shui, Lingling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecularly imprinted polymer decorated 3D-framework of functionalized multi-walled carbon nanotubes for ultrasensitive electrochemical sensing of Norfloxacin in pharmaceutical formulations and rat plasma</atitle><jtitle>Sensors and actuators. B, Chemical</jtitle><date>2019-06-01</date><risdate>2019</risdate><volume>288</volume><spage>363</spage><epage>372</epage><pages>363-372</pages><issn>0925-4005</issn><eissn>1873-3077</eissn><abstract>[Display omitted] •Molecularly imprinted polymer decorated 3D-framework of fMWCNTs was synthesis.•Fabricated electrochemical sensors were applied for Norfloxacin determination in pharmaceutical formulations and rat plasma.•The sensors show low detection-limit, wide linear-range and high selectivity for Norfloxacin detection. In this work, a 3D-framework of functionalized multi-walled carbon nanotubes (fMWCNTs) decorated with molecularly imprinted polymer (MIP), has been fabricated to achieve fast and ultrasensitive electrochemical molecular sensing. The cavity networks of MIP layer from Norfloxacin (NFX) molecules offers simultaneous identification and quantification of NFX; and thus, ensures its high selectivity. The porous structure of fMWCNT 3D-framwork effectively increases the specific surface area, and the copolymer of fMWCNTs and MIP shows synergistic effect for electrocatalytic reaction of NFX at the modified sensor. Under optimized conditions, the fabricated sensors show wide linear detection ranges of 0.003-0.391 μM and 0.391–3.125 μM, low limit of determination (LOD) of 1.58 nM, and excellent selectivity in discriminating NFX according to its structural analogues and possible interferences. Precise and fast quantification of NFX in pharmaceutical formulations (Yunnan Baiyao and Ouyi Pharmaceutical) and rat plasma samples (N = 4) suggests its simplicity and reliability. The recoveries from pharmaceutical formulations ranged from 97.36 to 109.58% with the precisions (relative standard deviations, RSD, n = 3) of 1.74–3.41%; and the recoveries from rat plasma samples ranged from 83.00 to 115.67% with RSDs (n = 3) of 0.45–10.30%. Considering the advantages of easy fabrication, and selective and sensitive detection, such sensors with different types of MIPs would be widely applied in the fields of pharmaceutical analysis, and environmental and clinical therapeutic drug monitoring.</abstract><cop>Lausanne</cop><pub>Elsevier B.V</pub><doi>10.1016/j.snb.2019.02.097</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5976-1355</orcidid></addata></record>
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subjects 3D-framework
Carbon nanotubes
Electrochemical sensor
Formulations
Molecularly imprinted polymer
Multi wall carbon nanotubes
Norfloxacin
Pharmaceuticals
Polymers
Selectivity
Sensors
Synergistic effect
title Molecularly imprinted polymer decorated 3D-framework of functionalized multi-walled carbon nanotubes for ultrasensitive electrochemical sensing of Norfloxacin in pharmaceutical formulations and rat plasma
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