Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat

Cardiovascular Pulmonary Research Laboratory, Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, Colorado Submitted 23 August 2005 ; accepted in final form 29 November 2005 The fawn-hooded rat (FHR) develops severe pulmonary hypertension (PH) when raised for...

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Veröffentlicht in:	Journal of applied physiology (1985) 2006-03, Vol.100 (3), p.996-1002
Hauptverfasser:	Nagaoka, Tetsutaro, Gebb, Sarah A, Karoor, Vijaya, Homma, Noriyuki, Morris, Kenneth G, McMurtry, Ivan F, Oka, Masahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology Altitude Animals Biological and medical sciences Blood Pressure - physiology Blotting, Western Calcium - pharmacology Calcium - physiology Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation Hemodynamics - drug effects Hypertension Hypertension, Pulmonary - etiology Hypertension, Pulmonary - genetics Hypertension, Pulmonary - metabolism Hypertrophy, Right Ventricular - metabolism Intracellular Signaling Peptides and Proteins Protein-Serine-Threonine Kinases - analysis Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Pulmonary Alveoli - pathology Pulmonary arteries Pulmonary Artery - chemistry Pulmonary Artery - pathology Rats Rats, Inbred Strains rho-Associated Kinases rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism Rodents Signal Transduction Vasoconstriction - drug effects
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