Optimization of the Synthesis of an Apelin-12 Structural Analog and the NMR Study of Its Stability in Human Plasma

A method for the solid-phase synthesis of the apelin-12 analog has been developed using the Fmoc methodology in combination with the temporary protection of the guanidine function of the arginine residues by protonation (salt formation) during the formation of the amide bond. Proton magnetic resonan...

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Veröffentlicht in:	Russian journal of bioorganic chemistry 2019, Vol.45 (1), p.18-26
Hauptverfasser:	Sidorova, M. V., Palkeeva, M. E., Azmuko, A. A., Ovchinnikov, M. V., Molokoedov, A. S., Bushuev, V. N., Pisarenko, O. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Blood plasma Life Sciences NMR Nuclear magnetic resonance Optimization Organic Chemistry Proton magnetic resonance Protonation Solid phase synthesis Solid phases
Online-Zugang:	Volltext
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