Colchicine-induced myoneuropathy in childhood
Colchicine is used in the treatment of gouty arthritis, familial Mediterranean fever, amyloidosis, Behcet disease and dermatoses. Myoneuropathy is a rare side-effect reported either with intoxication or in elderly patients with chronic renal insufficiency causing elevated plasma drug levels. We repo...
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| Veröffentlicht in: | European journal of pediatrics 1998-10, Vol.157 (10), p.853-855 |
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| container_title | European journal of pediatrics |
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| creator | HAREL, L MUKAMEL, M AMIR, J STRAUSSBERG, R COHEN, A. H VARSANO, I |
| description | Colchicine is used in the treatment of gouty arthritis, familial Mediterranean fever, amyloidosis, Behcet disease and dermatoses. Myoneuropathy is a rare side-effect reported either with intoxication or in elderly patients with chronic renal insufficiency causing elevated plasma drug levels. We report the first two cases of myoneuropathy in children, both taking appropriate doses of colchicine, and having normal renal function. The myoneuropathic changes were reversible after stopping treatment. The cause of colchicine myoneuropathy is unclear.
In children treated with colchicine, neuromuscular phenomena of unknown aetiology may be related to the drug, even with a lack of intoxication or renal insufficiency. |
| doi_str_mv | 10.1007/s004310050952 |
| format | Article |
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In children treated with colchicine, neuromuscular phenomena of unknown aetiology may be related to the drug, even with a lack of intoxication or renal insufficiency.</description><identifier>ISSN: 0340-6199</identifier><identifier>EISSN: 1432-1076</identifier><identifier>DOI: 10.1007/s004310050952</identifier><identifier>PMID: 9809829</identifier><identifier>CODEN: EJPEDT</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adolescent ; Biological and medical sciences ; Child, Preschool ; Colchicine - adverse effects ; Colchicine - therapeutic use ; Drug toxicity and drugs side effects treatment ; Familial Mediterranean Fever - drug therapy ; Female ; Gout Suppressants - adverse effects ; Gout Suppressants - therapeutic use ; Humans ; Male ; Medical sciences ; Neuromuscular Diseases - chemically induced ; Pharmacology. Drug treatments ; Toxicity: nervous system and muscle</subject><ispartof>European journal of pediatrics, 1998-10, Vol.157 (10), p.853-855</ispartof><rights>1999 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-5091b8fb21a0d880b9627cfdd175dc017c5204a2265fe2e1c65f0b7f0289d7913</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1603361$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9809829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HAREL, L</creatorcontrib><creatorcontrib>MUKAMEL, M</creatorcontrib><creatorcontrib>AMIR, J</creatorcontrib><creatorcontrib>STRAUSSBERG, R</creatorcontrib><creatorcontrib>COHEN, A. H</creatorcontrib><creatorcontrib>VARSANO, I</creatorcontrib><title>Colchicine-induced myoneuropathy in childhood</title><title>European journal of pediatrics</title><addtitle>Eur J Pediatr</addtitle><description>Colchicine is used in the treatment of gouty arthritis, familial Mediterranean fever, amyloidosis, Behcet disease and dermatoses. Myoneuropathy is a rare side-effect reported either with intoxication or in elderly patients with chronic renal insufficiency causing elevated plasma drug levels. We report the first two cases of myoneuropathy in children, both taking appropriate doses of colchicine, and having normal renal function. The myoneuropathic changes were reversible after stopping treatment. The cause of colchicine myoneuropathy is unclear.
In children treated with colchicine, neuromuscular phenomena of unknown aetiology may be related to the drug, even with a lack of intoxication or renal insufficiency.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>Colchicine - adverse effects</subject><subject>Colchicine - therapeutic use</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Familial Mediterranean Fever - drug therapy</subject><subject>Female</subject><subject>Gout Suppressants - adverse effects</subject><subject>Gout Suppressants - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuromuscular Diseases - chemically induced</subject><subject>Pharmacology. 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H ; VARSANO, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-5091b8fb21a0d880b9627cfdd175dc017c5204a2265fe2e1c65f0b7f0289d7913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Child, Preschool</topic><topic>Colchicine - adverse effects</topic><topic>Colchicine - therapeutic use</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Familial Mediterranean Fever - drug therapy</topic><topic>Female</topic><topic>Gout Suppressants - adverse effects</topic><topic>Gout Suppressants - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuromuscular Diseases - chemically induced</topic><topic>Pharmacology. 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H</au><au>VARSANO, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Colchicine-induced myoneuropathy in childhood</atitle><jtitle>European journal of pediatrics</jtitle><addtitle>Eur J Pediatr</addtitle><date>1998-10-01</date><risdate>1998</risdate><volume>157</volume><issue>10</issue><spage>853</spage><epage>855</epage><pages>853-855</pages><issn>0340-6199</issn><eissn>1432-1076</eissn><coden>EJPEDT</coden><abstract>Colchicine is used in the treatment of gouty arthritis, familial Mediterranean fever, amyloidosis, Behcet disease and dermatoses. Myoneuropathy is a rare side-effect reported either with intoxication or in elderly patients with chronic renal insufficiency causing elevated plasma drug levels. We report the first two cases of myoneuropathy in children, both taking appropriate doses of colchicine, and having normal renal function. The myoneuropathic changes were reversible after stopping treatment. The cause of colchicine myoneuropathy is unclear.
In children treated with colchicine, neuromuscular phenomena of unknown aetiology may be related to the drug, even with a lack of intoxication or renal insufficiency.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>9809829</pmid><doi>10.1007/s004310050952</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Biological and medical sciences Child, Preschool Colchicine - adverse effects Colchicine - therapeutic use Drug toxicity and drugs side effects treatment Familial Mediterranean Fever - drug therapy Female Gout Suppressants - adverse effects Gout Suppressants - therapeutic use Humans Male Medical sciences Neuromuscular Diseases - chemically induced Pharmacology. Drug treatments Toxicity: nervous system and muscle |
| title | Colchicine-induced myoneuropathy in childhood |
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