Physiologically Based Pharmacokinetic Modeling Approach to Predict Drug‐Drug Interactions With Ethionamide Involving Impact of Genetic Polymorphism on FMO3

The widely used second‐line antituberculosis drug ethionamide shows wide interindividual variability in its disposition; however, the relevant factors affecting this phenomenon have not been characterized. We previously reported the major contribution of flavin‐containing monooxygenase 3 (FMO3) in t...

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Veröffentlicht in:	Journal of clinical pharmacology 2019-06, Vol.59 (6), p.880-889
Hauptverfasser:	Nguyen, Phuong Thi Thu, Parvez, Md Masud, Kim, Min Jung, Yoo, Sung Eun, Ahn, Sangzin, Ghim, Jong‐Lyul, Shin, Jae‐Gook
Format:	Artikel
Sprache:	eng
Schlagworte:	Computer simulation Dimethylaniline monooxygenase (N-oxide-forming) Drug interaction Drug interactions drug‐drug interactions Ethionamide Flavin FMO3 Gene polymorphism genetic polymorphism Heterogeneity Metabolism PBPK Pharmacokinetics Polymorphism
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