Activation of human CD141+ and CD1c+ dendritic cells in vivo with combined TLR3 and TLR7/8 ligation

Mice reconstituted with human hematopoietic stem cells are valuable models to study aspects of the human immune system in vivo. We describe a humanized mouse model (hu mice) in which fully functional human CD141+ and CD1c+ myeloid and CD123+ plasmacytoid dendritic cells (DC) develop from human cord...

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Veröffentlicht in:	Immunology and cell biology 2018-04, Vol.96 (4), p.390-400
Hauptverfasser:	Pearson, Frances E, Chang, Karshing, Minoda, Yoshihito, Rojas, Ingrid M Leal, Haigh, Oscar L, Daraj, Ghazal, Tullett, Kirsteen M, Radford, Kristen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animal models Animals Antigen presentation Antigens, CD1 - metabolism Antigens, Surface - metabolism Cancer Cancer immunotherapy CD103 antigen CD123 antigen CD141+ DC CD1c antigen CD1c+ DC CD34 antigen CD8 antigen CD80 antigen CD83 antigen CD86 antigen Cell activation Cell Differentiation - drug effects Cells Cord blood Costimulator CXCL10 protein Cytokines - blood Cytotoxicity dendritic cell Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Double-stranded RNA humanized mouse Humans Imidazoles - pharmacology Immune system Immunodeficiency Immunotherapy Interleukin 12 Liver - drug effects Liver - metabolism Lung - drug effects Lung - metabolism Lymphocytes T Lymphoid Tissue - drug effects Lymphoid Tissue - metabolism Mice Poly I-C - pharmacology poly I:C R848 Rodents Stem cells TLR Toll-Like Receptors - agonists Toll-Like Receptors - metabolism Up-Regulation - drug effects α-Interferon
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