Role of Antigen-Induced Cytokine Release in Atopic Pruritus
In order to further evaluate the role of cytokines in the induction of atopic pruritus, leukocytes from 10 atopic eczema patients or 10 nonallergic controls were stimulated in vitro with mite or birch pollen antigen for 1 and 4 days. Subjects were prick-tested with the supernatants, and whealing and...
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| Veröffentlicht in: | International archives of allergy and immunology 1998-05, Vol.116 (1), p.36-39 |
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| creator | Lippert, U. Hoer, A. Möller, A. Ramboer, I. Cremer, B. Henz, B. M. |
| description | In order to further evaluate the role of cytokines in the induction of atopic pruritus, leukocytes from 10 atopic eczema patients or 10 nonallergic controls were stimulated in vitro with mite or birch pollen antigen for 1 and 4 days. Subjects were prick-tested with the supernatants, and whealing and itching were evaluated 20 and 60 min later. The supernatants were also examined for the contents of GM-CSF, IL-2, IL-6 and IL-8 by ELISA and TNFα. Two hours prior to testing, the antihistamine cetirizine (20 mg) or a placebo tablet were given to the patients according to a randomized, double-blind study protocol. After pricking with antigen-stimulated leukocyte supernatants, 6 of 10 patients but no controls reacted mostly at 20 min with whealing and/or pruritus. In the cetirizine-treated group, no decrease in these skin reactions was seen compared to placebo. Analysis for cytokines showed increased levels of IL-8 in allergen-stimulated samples, with no correlation to the induction of itching or whealing by these supernatants. IL-6 levels were low and variable, and GM-CSF, IL-2 and TNFα levels were always below standard values. These data show that leukocytes selectively release IL-8 in response to in vitro antigen stimulation. They furthermore provide additional support for the concept that as yet to be identified products play a role in atopic pruritus. |
| doi_str_mv | 10.1159/000023922 |
| format | Article |
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M.</creator><creatorcontrib>Lippert, U. ; Hoer, A. ; Möller, A. ; Ramboer, I. ; Cremer, B. ; Henz, B. M.</creatorcontrib><description>In order to further evaluate the role of cytokines in the induction of atopic pruritus, leukocytes from 10 atopic eczema patients or 10 nonallergic controls were stimulated in vitro with mite or birch pollen antigen for 1 and 4 days. Subjects were prick-tested with the supernatants, and whealing and itching were evaluated 20 and 60 min later. The supernatants were also examined for the contents of GM-CSF, IL-2, IL-6 and IL-8 by ELISA and TNFα. Two hours prior to testing, the antihistamine cetirizine (20 mg) or a placebo tablet were given to the patients according to a randomized, double-blind study protocol. After pricking with antigen-stimulated leukocyte supernatants, 6 of 10 patients but no controls reacted mostly at 20 min with whealing and/or pruritus. In the cetirizine-treated group, no decrease in these skin reactions was seen compared to placebo. Analysis for cytokines showed increased levels of IL-8 in allergen-stimulated samples, with no correlation to the induction of itching or whealing by these supernatants. IL-6 levels were low and variable, and GM-CSF, IL-2 and TNFα levels were always below standard values. These data show that leukocytes selectively release IL-8 in response to in vitro antigen stimulation. They furthermore provide additional support for the concept that as yet to be identified products play a role in atopic pruritus.</description><identifier>ISSN: 1018-2438</identifier><identifier>EISSN: 1423-0097</identifier><identifier>DOI: 10.1159/000023922</identifier><identifier>PMID: 9623507</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adolescent ; Adult ; Allergens - immunology ; Allergens - pharmacology ; Allergic diseases ; Animals ; Anti-Allergic Agents - administration & dosage ; Anti-Allergic Agents - therapeutic use ; Antigens - immunology ; Antigens - pharmacology ; Biological and medical sciences ; Cetirizine - administration & dosage ; Cetirizine - therapeutic use ; Cross-Over Studies ; Culture Media, Conditioned - adverse effects ; Culture Media, Conditioned - chemistry ; Culture Media, Conditioned - pharmacology ; Cytokines - drug effects ; Cytokines - physiology ; Cytokines - secretion ; Dermatitis, Atopic - drug therapy ; Dermatitis, Atopic - immunology ; Dose-Response Relationship, Drug ; Double-Blind Method ; Enzyme-Linked Immunosorbent Assay ; Female ; Granulocyte-Macrophage Colony-Stimulating Factor - analysis ; Granulocyte-Macrophage Colony-Stimulating Factor - secretion ; Humans ; Hypersensitivity, Immediate - immunology ; Immunopathology ; Interleukin-2 - analysis ; Interleukin-2 - secretion ; Interleukin-8 - administration & dosage ; Interleukin-8 - adverse effects ; Interleukin-8 - secretion ; Male ; Medical sciences ; Middle Aged ; Mites - immunology ; Original Paper ; Pollen - immunology ; Pruritus - drug therapy ; Pruritus - immunology ; Severity of Illness Index ; Skin allergic diseases. 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M.</creatorcontrib><title>Role of Antigen-Induced Cytokine Release in Atopic Pruritus</title><title>International archives of allergy and immunology</title><addtitle>Int Arch Allergy Immunol</addtitle><description>In order to further evaluate the role of cytokines in the induction of atopic pruritus, leukocytes from 10 atopic eczema patients or 10 nonallergic controls were stimulated in vitro with mite or birch pollen antigen for 1 and 4 days. Subjects were prick-tested with the supernatants, and whealing and itching were evaluated 20 and 60 min later. The supernatants were also examined for the contents of GM-CSF, IL-2, IL-6 and IL-8 by ELISA and TNFα. Two hours prior to testing, the antihistamine cetirizine (20 mg) or a placebo tablet were given to the patients according to a randomized, double-blind study protocol. After pricking with antigen-stimulated leukocyte supernatants, 6 of 10 patients but no controls reacted mostly at 20 min with whealing and/or pruritus. In the cetirizine-treated group, no decrease in these skin reactions was seen compared to placebo. Analysis for cytokines showed increased levels of IL-8 in allergen-stimulated samples, with no correlation to the induction of itching or whealing by these supernatants. IL-6 levels were low and variable, and GM-CSF, IL-2 and TNFα levels were always below standard values. These data show that leukocytes selectively release IL-8 in response to in vitro antigen stimulation. They furthermore provide additional support for the concept that as yet to be identified products play a role in atopic pruritus.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergens - immunology</subject><subject>Allergens - pharmacology</subject><subject>Allergic diseases</subject><subject>Animals</subject><subject>Anti-Allergic Agents - administration & dosage</subject><subject>Anti-Allergic Agents - therapeutic use</subject><subject>Antigens - immunology</subject><subject>Antigens - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cetirizine - administration & dosage</subject><subject>Cetirizine - therapeutic use</subject><subject>Cross-Over Studies</subject><subject>Culture Media, Conditioned - adverse effects</subject><subject>Culture Media, Conditioned - chemistry</subject><subject>Culture Media, Conditioned - pharmacology</subject><subject>Cytokines - drug effects</subject><subject>Cytokines - physiology</subject><subject>Cytokines - secretion</subject><subject>Dermatitis, Atopic - drug therapy</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - analysis</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - secretion</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - immunology</subject><subject>Immunopathology</subject><subject>Interleukin-2 - analysis</subject><subject>Interleukin-2 - secretion</subject><subject>Interleukin-8 - administration & dosage</subject><subject>Interleukin-8 - adverse effects</subject><subject>Interleukin-8 - secretion</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mites - immunology</subject><subject>Original Paper</subject><subject>Pollen - immunology</subject><subject>Pruritus - drug therapy</subject><subject>Pruritus - immunology</subject><subject>Severity of Illness Index</subject><subject>Skin allergic diseases. Stinging insect allergies</subject><subject>Skin Diseases - chemically induced</subject><subject>Skin Diseases - immunology</subject><subject>Skin Tests</subject><subject>Time Factors</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>Tumor Necrosis Factor-alpha - secretion</subject><issn>1018-2438</issn><issn>1423-0097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0M9LwzAUB_AgypzTg2cRiojgoZqfbYOnMvwxGChDzyFN0tGta2rSHvbfG12ZIL5LQt6Hl8cXgHME7xBi_B6GwoRjfADGiGISQ8jTw3CHKIsxJdkxOPF-BWHAWTICI55gwmA6Bg8LW5vIllHedNXSNPGs0b0yOppuO7uuGhMtTG2kN1HVRHln20pFb653Vdf7U3BUytqbs-GcgI-nx_fpSzx_fZ5N83msKKJdrDUrM1LqUKRM0_AIWYIZJpJTpniKtSQ4RUZLxHlmOKWqKHgBUUKTBCpKJuBmN7d19rM3vhObyitT17IxtvciQMJwAgO8-gNXtndN2E1gjLKQEE8Cut0h5az3zpSiddVGuq1AUHynKfZpBns5DOyLjdF7OcQX-tdDX3ol69LJRlV-zzBmlHD2u9dauqVx-_4sz3_-Ea0uA7r4F-02-QK3io1V</recordid><startdate>19980501</startdate><enddate>19980501</enddate><creator>Lippert, U.</creator><creator>Hoer, A.</creator><creator>Möller, A.</creator><creator>Ramboer, I.</creator><creator>Cremer, B.</creator><creator>Henz, B. 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M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-dd5f83fdddd3f77c410562523a945c972da3271eda1998e944cbb9b0164660c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Allergens - immunology</topic><topic>Allergens - pharmacology</topic><topic>Allergic diseases</topic><topic>Animals</topic><topic>Anti-Allergic Agents - administration & dosage</topic><topic>Anti-Allergic Agents - therapeutic use</topic><topic>Antigens - immunology</topic><topic>Antigens - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cetirizine - administration & dosage</topic><topic>Cetirizine - therapeutic use</topic><topic>Cross-Over Studies</topic><topic>Culture Media, Conditioned - adverse effects</topic><topic>Culture Media, Conditioned - chemistry</topic><topic>Culture Media, Conditioned - pharmacology</topic><topic>Cytokines - drug effects</topic><topic>Cytokines - physiology</topic><topic>Cytokines - secretion</topic><topic>Dermatitis, Atopic - drug therapy</topic><topic>Dermatitis, Atopic - immunology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor - analysis</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor - secretion</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - immunology</topic><topic>Immunopathology</topic><topic>Interleukin-2 - analysis</topic><topic>Interleukin-2 - secretion</topic><topic>Interleukin-8 - administration & dosage</topic><topic>Interleukin-8 - adverse effects</topic><topic>Interleukin-8 - secretion</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mites - immunology</topic><topic>Original Paper</topic><topic>Pollen - immunology</topic><topic>Pruritus - drug therapy</topic><topic>Pruritus - immunology</topic><topic>Severity of Illness Index</topic><topic>Skin allergic diseases. 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M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Antigen-Induced Cytokine Release in Atopic Pruritus</atitle><jtitle>International archives of allergy and immunology</jtitle><addtitle>Int Arch Allergy Immunol</addtitle><date>1998-05-01</date><risdate>1998</risdate><volume>116</volume><issue>1</issue><spage>36</spage><epage>39</epage><pages>36-39</pages><issn>1018-2438</issn><eissn>1423-0097</eissn><abstract>In order to further evaluate the role of cytokines in the induction of atopic pruritus, leukocytes from 10 atopic eczema patients or 10 nonallergic controls were stimulated in vitro with mite or birch pollen antigen for 1 and 4 days. Subjects were prick-tested with the supernatants, and whealing and itching were evaluated 20 and 60 min later. The supernatants were also examined for the contents of GM-CSF, IL-2, IL-6 and IL-8 by ELISA and TNFα. Two hours prior to testing, the antihistamine cetirizine (20 mg) or a placebo tablet were given to the patients according to a randomized, double-blind study protocol. After pricking with antigen-stimulated leukocyte supernatants, 6 of 10 patients but no controls reacted mostly at 20 min with whealing and/or pruritus. In the cetirizine-treated group, no decrease in these skin reactions was seen compared to placebo. Analysis for cytokines showed increased levels of IL-8 in allergen-stimulated samples, with no correlation to the induction of itching or whealing by these supernatants. IL-6 levels were low and variable, and GM-CSF, IL-2 and TNFα levels were always below standard values. These data show that leukocytes selectively release IL-8 in response to in vitro antigen stimulation. They furthermore provide additional support for the concept that as yet to be identified products play a role in atopic pruritus.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>9623507</pmid><doi>10.1159/000023922</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1018-2438 |
| ispartof | International archives of allergy and immunology, 1998-05, Vol.116 (1), p.36-39 |
| issn | 1018-2438 1423-0097 |
| language | eng |
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| source | MEDLINE; Karger Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Allergens - immunology Allergens - pharmacology Allergic diseases Animals Anti-Allergic Agents - administration & dosage Anti-Allergic Agents - therapeutic use Antigens - immunology Antigens - pharmacology Biological and medical sciences Cetirizine - administration & dosage Cetirizine - therapeutic use Cross-Over Studies Culture Media, Conditioned - adverse effects Culture Media, Conditioned - chemistry Culture Media, Conditioned - pharmacology Cytokines - drug effects Cytokines - physiology Cytokines - secretion Dermatitis, Atopic - drug therapy Dermatitis, Atopic - immunology Dose-Response Relationship, Drug Double-Blind Method Enzyme-Linked Immunosorbent Assay Female Granulocyte-Macrophage Colony-Stimulating Factor - analysis Granulocyte-Macrophage Colony-Stimulating Factor - secretion Humans Hypersensitivity, Immediate - immunology Immunopathology Interleukin-2 - analysis Interleukin-2 - secretion Interleukin-8 - administration & dosage Interleukin-8 - adverse effects Interleukin-8 - secretion Male Medical sciences Middle Aged Mites - immunology Original Paper Pollen - immunology Pruritus - drug therapy Pruritus - immunology Severity of Illness Index Skin allergic diseases. Stinging insect allergies Skin Diseases - chemically induced Skin Diseases - immunology Skin Tests Time Factors Tumor Necrosis Factor-alpha - analysis Tumor Necrosis Factor-alpha - secretion |
| title | Role of Antigen-Induced Cytokine Release in Atopic Pruritus |
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