Reduced Airway Inflammation and Remodeling in Parallel with Mucin 5AC Protein Expression Decreased by S-Carboxymethylcysteine, a Mucoregulant, in the Airways of Rats Exposed to Sulfur Dioxide

Background: Human obstructive airway diseases are histopathologically characterized by inflammatory cell infiltration, goblet cell hyperplasia, and mucus hypersecretion in airways. We prepared a rat model of airway injury by exposure of sulfur dioxide (SO 2 ) and then evaluated the effects of S-carb...

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Veröffentlicht in:	International archives of allergy and immunology 2004-08, Vol.134 (4), p.273-280
Hauptverfasser:	Sueyoshi, Sumihisa, Miyata, Yuki, Masumoto, Yoshihiro, Ishibashi, Yuji, Matsuzawa, Shigeki, Harano, Naoki, Tsuru, Kiyoyuki, Imai, Shigeru
Format:	Artikel
Sprache:	eng
Schlagworte:	Air Pollutants - adverse effects Animals Biological and medical sciences Bronchitis - chemically induced Bronchitis - metabolism Carbocysteine - pharmacology Disease Models, Animal Expectorants - pharmacology Fundamental and applied biological sciences. Psychology Fundamental immunology Gases Goblet Cells - drug effects Goblet Cells - metabolism Immunohistochemistry Immunopathology Inhalation Exposure - adverse effects Male Medical sciences Mucin 5AC Mucins - biosynthesis Mucins - drug effects Original Paper Proteins Rats Rats, Wistar Respiratory diseases Respiratory Mucosa - cytology Respiratory Mucosa - drug effects Rodents Sulfur Sulfur Dioxide - adverse effects
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