Delayed IL-21 treatment preferentially expands peptide-specific CD8 + T cells by reducing bystander activation of T cells

We previously reported a simple and practical procedure to generate peptide-specific CD8 T cells using peptide and IL-2, which is applied to produce human telomerase reverse transcriptase (hTERT)-specific CD8+ T cells for clinical use. We have modified the procedure to enhance the amplification of p...

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Veröffentlicht in:	Immunotherapy 2019-04, Vol.11 (6), p.497-513
Hauptverfasser:	Kim, Seon-Hee, Park, Sang-Yoon, Lim, Myong Cheol, Lee, Eun Sook, Lee, Eun Gyeong, Han, Seoung-Eun, Kim, Young-Ho, Kwon, Byoung S, Choi, Beom K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Antigens, Neoplasm - immunology Bystander Effect Cancer CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell activation Cell culture Cell growth Cell Proliferation Cells, Cultured Clinical trials Cytokines Cytomegalovirus Flow cytometry Histocompatibility antigen HLA HLA-A2 Antigen - metabolism Humans Immunology Immunotherapy Immunotherapy, Adoptive - methods Interleukin 2 Interleukin 21 Interleukins - metabolism Lymphocyte Activation Lymphocytes Lymphocytes T Medical research Neoplasms - immunology Neoplasms - therapy Peptides Peptides - immunology Peptides - metabolism Pp65 protein Protein Binding RNA-directed DNA polymerase T-Cell Antigen Receptor Specificity Telomerase Telomerase reverse transcriptase Viral Matrix Proteins - immunology Viral Matrix Proteins - metabolism WT1 protein
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