Hyperthermia and radiotherapy combination for locoregional recurrences of breast cancer: a review
Breast cancer is a second common form of malignancy and is one of the leading causes of mortality among cancer patients across the world. Locoregional recurrence occurs in 5-20% of patients despite upfront treatment. Local therapy (surgery plus minus re-irradiation) with or without systemic therapy...
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| Veröffentlicht in: | Breast cancer management 2017-11, Vol.6 (4), p.117-126 |
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| container_title | Breast cancer management |
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| creator | Arslan, Suheyla Aytac Ozdemir, Nuriye Sendur, Mehmet Ali Eren, Tulay Ozturk, Huseyin Furkan Aral, Ipek P nar Soykut, Ela Delikgoz Inan, Gonca Altinisik |
| description | Breast cancer is a second common form of malignancy and is one of the leading causes of mortality among cancer patients across the world. Locoregional recurrence occurs in 5-20% of patients despite upfront treatment. Local therapy (surgery plus minus re-irradiation) with or without systemic therapy is generally recommended for management. Local control rates vary; months to years, but a significant percentage lives 5 years. Therefore, treatment strategies to increase response rates are significant. Hyperthermia is one of the most potent radiosensitizers and data from meta-analysis and randomized trials support its use with radiotherapy. This study reviews the biologic rationale and clinical evidence about concomitant use of hyperthermia and radiotherapy in locally-recurrent breast cancer patients. |
| doi_str_mv | 10.2217/bmt-2017-0011 |
| format | Article |
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| ispartof | Breast cancer management, 2017-11, Vol.6 (4), p.117-126 |
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| language | eng |
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| source | Taylor & Francis Open Access |
| subjects | Breast cancer Cancer therapies Cell cycle Fever Heat Hyperthermia Mastectomy Medical prognosis Metastasis Proteins Radiation therapy radiotherapy Surgery Systematic review Tumors |
| title | Hyperthermia and radiotherapy combination for locoregional recurrences of breast cancer: a review |
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