Decreased ciliary beat responsiveness to acetylcholine in the nasal polyp epithelium

Objective We investigated the difference in ciliary beat responsiveness to acetylcholine in ex vivo and the difference in the expressions of associated molecules (M1/M3 muscarinic receptors, pannexin‐1 and P2X7 purinergic receptor) between the nasal polyp and turbinate mucosa. Study design Laborator...

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Veröffentlicht in:	Clinical otolaryngology 2019-05, Vol.44 (3), p.356-365
Hauptverfasser:	Do, Hung Ba, Ohbuchi, Toyoaki, Yokoyama, Mitsuru, Kitamura, Takuro, Wakasugi, Tetsuro, Ohkubo, Jun‐ichi, Suzuki, Hideaki
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine Acetylcholine - pharmacology Acetylcholine receptors (muscarinic) Adolescent Adult Aged Aged, 80 and over Beat frequencies Bone Child Cilia Cilia - drug effects Cilia - ultrastructure Cilia beat frequency ciliary beat frequency Ciliary movement Connexins - metabolism Epithelium Eutrophication Female Fluorescence Humans Immunohistochemistry Male Middle Aged Mucociliary Clearance - drug effects Mucosa muscarinic receptor Nasal Mucosa - drug effects Nasal Mucosa - metabolism nasal polyp Nasal Polyps - metabolism Nasal Polyps - surgery Nerve Tissue Proteins - metabolism Nose P2X7 purinergic receptor pannexin‐1 channel Polymerase chain reaction Receptor, Muscarinic M1 - metabolism Receptor, Muscarinic M2 - metabolism Receptors Receptors, Purinergic P2X7 - metabolism Reverse transcription Rhinitis Rhinitis - surgery RNA, Messenger - metabolism Scanning electron microscopy Surgery Tissues Turbinates - drug effects Turbinates - metabolism Turbinates - ultrastructure
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