A Ru(II)-p-cymene compound bearing naproxen-pyridineamide. Synthesis, spectroscopic studies, computational analysis and in vitro anticancer activity against lung cells compared to Ru(II)-p-cymene-naproxen and the corresponding drug ligands

A new Ru(η6-p-cymene) bearing the naproxen-pyridineamide (Npxpya) is synthesized and characterized by ESI-MS, NMR, ATR/FT-IR, UV/VIS and DFT computational calculations. Photophysical properties, antiproliferative activity, effects on mitochondrial membrane potential and cell cycle arrest in lung can...

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Veröffentlicht in:	Inorganica Chimica Acta 2019-04, Vol.489, p.27-38
Hauptverfasser:	Tabares, Julie Pauline Gaitan, Santos, Rodrigo Luis S.R., Cassiano, Jefferson Luiz, Zaim, Marcio H., Honorato, João, Batista, Alzir A., Teixeira, Sarah F., Ferreira, Adilson Kleber, Viana, Rommel B., Martínez, Sandra Quispe, Stábile, Antonio Carlos, de Oliveira Silva, Denise
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Aromatic compounds Bearing Cancer Computation Ligands Luminescence Metallodrug Naproxen Naproxen-pyridineamide NMR Nuclear magnetic resonance Optical properties Organometallic compounds p-Cymene Ruthenium(II) organometallics Solvents Time dependence
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