HOX transcript antisense RNA (HOTAIR) in cancer
Long noncoding RNAs (lncRNAs) have emerged as a new family of master regulators of cancer. The lncRNA HOX transcript antisense RNA (HOTAIR) is a prime example of an oncogenic trans-acting lncRNA. The expression of HOTAIR is elevated in a broad spectrum of cancers and is associated with metastasis an...
Gespeichert in:
| Veröffentlicht in: | Cancer letters 2019-07, Vol.454, p.90-97 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 97 |
|---|---|
| container_issue | |
| container_start_page | 90 |
| container_title | Cancer letters |
| container_volume | 454 |
| creator | Qu, Xiaohan Alsager, Simon Zhuo, Ying Shan, Bin |
| description | Long noncoding RNAs (lncRNAs) have emerged as a new family of master regulators of cancer. The lncRNA HOX transcript antisense RNA (HOTAIR) is a prime example of an oncogenic trans-acting lncRNA. The expression of HOTAIR is elevated in a broad spectrum of cancers and is associated with metastasis and poor prognosis. HOTAIR governs fundamental biochemical and cellular processes via interactions with a variety of partners to promote proliferation, invasion, survival, drug resistance, and metastasis in preclinical studies of cancer. Here, we review the diagnostic and therapeutic potential of HOTAIR as well as the molecular mechanisms underlying the dysregulation of its expression and function in cancer. We also discuss the challenges to capitalizing on HOTAIR for more effective patient care along with future directions founded on the recent exciting advances in our knowledge of HOTAIR in cancer.
•We explored the impact of a novel isoform of HOTAIR on dysregulation of HOTAIR expression and functions in cancer.•We discussed potential cis actions of the novel HOTAIR isoform and R-loops within this isoform in cancer.•We comprehensively reviewed the PRC2-independent functions of HOTAIR in cancer. |
| doi_str_mv | 10.1016/j.canlet.2019.04.016 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2216249592</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0304383519302411</els_id><sourcerecordid>2216249592</sourcerecordid><originalsourceid>FETCH-LOGICAL-c456t-d1f5c358764591c791bf83a5350d3870cda1e3f8a841aca95cfa84dc80ae1cce3</originalsourceid><addsrcrecordid>eNp9UF1LwzAUDaK4Of0HIgVf9KHdTZO0yYswhrrBcDAm-BayNIWUrZ1JJvjvzej00ad7OZwPzkHoFkOGARfjJtOq3ZqQ5YBFBjSL4BkaYl7maSk4nKMhEKAp4YQN0JX3DQAwWrJLNCAgOC6ZGKLxbPmRBKdar53dh0S1wXrTepOs3ibJw2y5nsxXj4ltk5imjbtGF7XaenNzuiP0_vK8ns7SxfJ1Pp0sUk1ZEdIK10wTxsuCMoF1KfCm5kQxwqAivARdKWxIzRWnWGklmK7jW2kOymCtDRmh-95377rPg_FBNt3BtTFS5jkuciqYyCOL9iztOu-dqeXe2Z1y3xKDPK4kG9mvJI8rSaAyglF2dzI_bHam-hP9zhIJTz3BxIpf1jjptTWxf2Wd0UFWnf0_4Qc86neo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2216249592</pqid></control><display><type>article</type><title>HOX transcript antisense RNA (HOTAIR) in cancer</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Qu, Xiaohan ; Alsager, Simon ; Zhuo, Ying ; Shan, Bin</creator><creatorcontrib>Qu, Xiaohan ; Alsager, Simon ; Zhuo, Ying ; Shan, Bin</creatorcontrib><description>Long noncoding RNAs (lncRNAs) have emerged as a new family of master regulators of cancer. The lncRNA HOX transcript antisense RNA (HOTAIR) is a prime example of an oncogenic trans-acting lncRNA. The expression of HOTAIR is elevated in a broad spectrum of cancers and is associated with metastasis and poor prognosis. HOTAIR governs fundamental biochemical and cellular processes via interactions with a variety of partners to promote proliferation, invasion, survival, drug resistance, and metastasis in preclinical studies of cancer. Here, we review the diagnostic and therapeutic potential of HOTAIR as well as the molecular mechanisms underlying the dysregulation of its expression and function in cancer. We also discuss the challenges to capitalizing on HOTAIR for more effective patient care along with future directions founded on the recent exciting advances in our knowledge of HOTAIR in cancer.
•We explored the impact of a novel isoform of HOTAIR on dysregulation of HOTAIR expression and functions in cancer.•We discussed potential cis actions of the novel HOTAIR isoform and R-loops within this isoform in cancer.•We comprehensively reviewed the PRC2-independent functions of HOTAIR in cancer.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2019.04.016</identifier><identifier>PMID: 30981759</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Androgens ; Antisense RNA ; Apoptosis ; Biomarkers ; Breast cancer ; Cancer ; Cell cycle ; DNA methylation ; Drug resistance ; Epigenetics ; G-quadruplex ; Gastric cancer ; Gene expression ; Genomes ; Humans ; Lymphatic system ; Medical prognosis ; Metastases ; Metastasis ; Molecular modelling ; Neoplasms - diagnosis ; Neoplasms - genetics ; Neoplasms - pathology ; Neoplasms - therapy ; PRC2 ; Prostate cancer ; Proteins ; R-loop ; Ribonucleic acid ; RNA ; RNA polymerase ; RNA, Long Noncoding - biosynthesis ; RNA, Long Noncoding - genetics ; Transcription ; Tumors</subject><ispartof>Cancer letters, 2019-07, Vol.454, p.90-97</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><rights>2019. Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-d1f5c358764591c791bf83a5350d3870cda1e3f8a841aca95cfa84dc80ae1cce3</citedby><cites>FETCH-LOGICAL-c456t-d1f5c358764591c791bf83a5350d3870cda1e3f8a841aca95cfa84dc80ae1cce3</cites><orcidid>0000-0003-1494-2333 ; 0000-0002-6869-2678</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2019.04.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30981759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qu, Xiaohan</creatorcontrib><creatorcontrib>Alsager, Simon</creatorcontrib><creatorcontrib>Zhuo, Ying</creatorcontrib><creatorcontrib>Shan, Bin</creatorcontrib><title>HOX transcript antisense RNA (HOTAIR) in cancer</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Long noncoding RNAs (lncRNAs) have emerged as a new family of master regulators of cancer. The lncRNA HOX transcript antisense RNA (HOTAIR) is a prime example of an oncogenic trans-acting lncRNA. The expression of HOTAIR is elevated in a broad spectrum of cancers and is associated with metastasis and poor prognosis. HOTAIR governs fundamental biochemical and cellular processes via interactions with a variety of partners to promote proliferation, invasion, survival, drug resistance, and metastasis in preclinical studies of cancer. Here, we review the diagnostic and therapeutic potential of HOTAIR as well as the molecular mechanisms underlying the dysregulation of its expression and function in cancer. We also discuss the challenges to capitalizing on HOTAIR for more effective patient care along with future directions founded on the recent exciting advances in our knowledge of HOTAIR in cancer.
•We explored the impact of a novel isoform of HOTAIR on dysregulation of HOTAIR expression and functions in cancer.•We discussed potential cis actions of the novel HOTAIR isoform and R-loops within this isoform in cancer.•We comprehensively reviewed the PRC2-independent functions of HOTAIR in cancer.</description><subject>Androgens</subject><subject>Antisense RNA</subject><subject>Apoptosis</subject><subject>Biomarkers</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cell cycle</subject><subject>DNA methylation</subject><subject>Drug resistance</subject><subject>Epigenetics</subject><subject>G-quadruplex</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Genomes</subject><subject>Humans</subject><subject>Lymphatic system</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Molecular modelling</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - therapy</subject><subject>PRC2</subject><subject>Prostate cancer</subject><subject>Proteins</subject><subject>R-loop</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA polymerase</subject><subject>RNA, Long Noncoding - biosynthesis</subject><subject>RNA, Long Noncoding - genetics</subject><subject>Transcription</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UF1LwzAUDaK4Of0HIgVf9KHdTZO0yYswhrrBcDAm-BayNIWUrZ1JJvjvzej00ad7OZwPzkHoFkOGARfjJtOq3ZqQ5YBFBjSL4BkaYl7maSk4nKMhEKAp4YQN0JX3DQAwWrJLNCAgOC6ZGKLxbPmRBKdar53dh0S1wXrTepOs3ibJw2y5nsxXj4ltk5imjbtGF7XaenNzuiP0_vK8ns7SxfJ1Pp0sUk1ZEdIK10wTxsuCMoF1KfCm5kQxwqAivARdKWxIzRWnWGklmK7jW2kOymCtDRmh-95377rPg_FBNt3BtTFS5jkuciqYyCOL9iztOu-dqeXe2Z1y3xKDPK4kG9mvJI8rSaAyglF2dzI_bHam-hP9zhIJTz3BxIpf1jjptTWxf2Wd0UFWnf0_4Qc86neo</recordid><startdate>20190710</startdate><enddate>20190710</enddate><creator>Qu, Xiaohan</creator><creator>Alsager, Simon</creator><creator>Zhuo, Ying</creator><creator>Shan, Bin</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0003-1494-2333</orcidid><orcidid>https://orcid.org/0000-0002-6869-2678</orcidid></search><sort><creationdate>20190710</creationdate><title>HOX transcript antisense RNA (HOTAIR) in cancer</title><author>Qu, Xiaohan ; Alsager, Simon ; Zhuo, Ying ; Shan, Bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-d1f5c358764591c791bf83a5350d3870cda1e3f8a841aca95cfa84dc80ae1cce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Androgens</topic><topic>Antisense RNA</topic><topic>Apoptosis</topic><topic>Biomarkers</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cell cycle</topic><topic>DNA methylation</topic><topic>Drug resistance</topic><topic>Epigenetics</topic><topic>G-quadruplex</topic><topic>Gastric cancer</topic><topic>Gene expression</topic><topic>Genomes</topic><topic>Humans</topic><topic>Lymphatic system</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Molecular modelling</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - therapy</topic><topic>PRC2</topic><topic>Prostate cancer</topic><topic>Proteins</topic><topic>R-loop</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA polymerase</topic><topic>RNA, Long Noncoding - biosynthesis</topic><topic>RNA, Long Noncoding - genetics</topic><topic>Transcription</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qu, Xiaohan</creatorcontrib><creatorcontrib>Alsager, Simon</creatorcontrib><creatorcontrib>Zhuo, Ying</creatorcontrib><creatorcontrib>Shan, Bin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qu, Xiaohan</au><au>Alsager, Simon</au><au>Zhuo, Ying</au><au>Shan, Bin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HOX transcript antisense RNA (HOTAIR) in cancer</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2019-07-10</date><risdate>2019</risdate><volume>454</volume><spage>90</spage><epage>97</epage><pages>90-97</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Long noncoding RNAs (lncRNAs) have emerged as a new family of master regulators of cancer. The lncRNA HOX transcript antisense RNA (HOTAIR) is a prime example of an oncogenic trans-acting lncRNA. The expression of HOTAIR is elevated in a broad spectrum of cancers and is associated with metastasis and poor prognosis. HOTAIR governs fundamental biochemical and cellular processes via interactions with a variety of partners to promote proliferation, invasion, survival, drug resistance, and metastasis in preclinical studies of cancer. Here, we review the diagnostic and therapeutic potential of HOTAIR as well as the molecular mechanisms underlying the dysregulation of its expression and function in cancer. We also discuss the challenges to capitalizing on HOTAIR for more effective patient care along with future directions founded on the recent exciting advances in our knowledge of HOTAIR in cancer.
•We explored the impact of a novel isoform of HOTAIR on dysregulation of HOTAIR expression and functions in cancer.•We discussed potential cis actions of the novel HOTAIR isoform and R-loops within this isoform in cancer.•We comprehensively reviewed the PRC2-independent functions of HOTAIR in cancer.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>30981759</pmid><doi>10.1016/j.canlet.2019.04.016</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1494-2333</orcidid><orcidid>https://orcid.org/0000-0002-6869-2678</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2019-07, Vol.454, p.90-97 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_proquest_journals_2216249592 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Androgens Antisense RNA Apoptosis Biomarkers Breast cancer Cancer Cell cycle DNA methylation Drug resistance Epigenetics G-quadruplex Gastric cancer Gene expression Genomes Humans Lymphatic system Medical prognosis Metastases Metastasis Molecular modelling Neoplasms - diagnosis Neoplasms - genetics Neoplasms - pathology Neoplasms - therapy PRC2 Prostate cancer Proteins R-loop Ribonucleic acid RNA RNA polymerase RNA, Long Noncoding - biosynthesis RNA, Long Noncoding - genetics Transcription Tumors |
| title | HOX transcript antisense RNA (HOTAIR) in cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-01T06%3A38%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=HOX%20transcript%20antisense%20RNA%20(HOTAIR)%20in%20cancer&rft.jtitle=Cancer%20letters&rft.au=Qu,%20Xiaohan&rft.date=2019-07-10&rft.volume=454&rft.spage=90&rft.epage=97&rft.pages=90-97&rft.issn=0304-3835&rft.eissn=1872-7980&rft_id=info:doi/10.1016/j.canlet.2019.04.016&rft_dat=%3Cproquest_cross%3E2216249592%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2216249592&rft_id=info:pmid/30981759&rft_els_id=S0304383519302411&rfr_iscdi=true |