Intermittent hypoxia promotes carcinogenesis in azoxymethane and dextran sodium sulfate‐induced colon cancer model

Intermittent hypoxia (IH), a characteristic of obstructive sleep apnea, is known to promote cancer progression and aggressiveness in mouse models. However, little is known regarding the effect of IH on cancer initiation. Here, the effect of IH on carcinogenesis was explored in azoxymethane (AOM) and...

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Veröffentlicht in:	Molecular carcinogenesis 2019-05, Vol.58 (5), p.654-665
Hauptverfasser:	Yoon, Dae Wui, Kim, Yi‐Sook, Hwang, Soyoung, Khalmuratova, Roza, Lee, Mingyu, Kim, Jee Hyun, Lee, Gah Young, Koh, Seong‐Joon, Park, Jong‐Wan, Shin, Hyun‐Woo
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxydeoxyguanosine Acetylcysteine Animal models Animals Antioxidants Apnea Azoxymethane Azoxymethane - toxicity Carcinogenesis Carcinogenesis - chemically induced Carcinogenesis - metabolism Carcinogenesis - pathology Carcinogens - toxicity Colitis - chemically induced Colitis - metabolism Colitis - pathology Colon cancer Colonic Neoplasms - chemically induced Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal cancer Dextran dextran sodium sulfate Dextran Sulfate - toxicity Disease Models, Animal Gene expression Hypoxia Hypoxia - physiopathology Inflammation - chemically induced Inflammation - metabolism Inflammation - pathology intermittent hypoxia Male Mice Mice, Inbred C57BL Oxidative stress Oxidative Stress - drug effects Protocol Reactive oxygen species Sleep Sleep disorders Sodium Sodium sulfate Sulfates Tumors
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