Facile synthesis of 2-(2-aminobenzoyl)benzoic acids via a base-promoted aerobic cascade reaction

Facile synthesis of 2-(2-aminobenzoyl)benzoic acids via a base-promoted aerobic cascade reaction

A novel strategy for the regiospecific synthesis of 2-(2-aminobenzoyl)benzoic acids via a base-promoted aerobic cascade reaction has been exploited. The protocol led to a wide panel of 2-(2-aminobenzoyl)benzoic acids with a broad substrate scope in an atom-economical manner. Six new bonds were seque...

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Veröffentlicht in:Organic Chemistry Frontiers 2019-05, Vol.6 (9), p.1383-1386
Hauptverfasser: Shen, Jinhai, Chen, Yangxin, Chen, Ting, Zou, Zhongai, Feng, Yadong, You, Qihua
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Benzoic acid
Cascade chemical reactions
Organic chemistry
Substrates
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Zusammenfassung:A novel strategy for the regiospecific synthesis of 2-(2-aminobenzoyl)benzoic acids via a base-promoted aerobic cascade reaction has been exploited. The protocol led to a wide panel of 2-(2-aminobenzoyl)benzoic acids with a broad substrate scope in an atom-economical manner. Six new bonds were sequentially formed in this one-pot procedure.
ISSN:2052-4129
2052-4110
2052-4129
2052-4110
DOI:10.1039/C9QO00101H