Osteopromotion with a plasmatransglutaminase on a [beta]-TCP ceramic
We investigated the osteopromotive properties of plasmatransglutaminase (F XIII), bone marrow and venous blood on a resorbable β-tricalcium phosphate (β-TCP) scaffold. A baseline binding and release study of F XIII from the scaffold showed a continuous release of 18% of the total dose after 48 h. Th...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2008-02, Vol.19 (2), p.659 |
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| container_title | Journal of materials science. Materials in medicine |
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| creator | Becker, Stephan Maissen, Otto Ponomarev, Igor Stoll, Thierry Meury, Thomas Sprecher, Christoph Alini, Mauro Wilke, Ingo |
| description | We investigated the osteopromotive properties of plasmatransglutaminase (F XIII), bone marrow and venous blood on a resorbable β-tricalcium phosphate (β-TCP) scaffold. A baseline binding and release study of F XIII from the scaffold showed a continuous release of 18% of the total dose after 48 h. The main study consisted of 18 adult sheep with cylindrical defects in both tibiae. The defects were filled with a β-TCP cylinder impregnated either with bone marrow, venous blood, F XIII or sheep were treated with 1250 IU F XIII intravenously over 14 days (n = 4 in each group). The defects were left open in two sheep. QCT and histology was performed after 6 and 12 weeks. The best bone ingrowth was seen after 6 weeks in the bone marrow group and after 12 weeks in the local F XIII group. The highest ingrowth on the inside of the cylinder proving the osteopromoting potential of F XIII was found in the local F XIII group. In our opinion F XIII is a good and readily available osteopromoting agent which can be used with β-TCP in cases of bone deficit to promote bone regeneration. (PUBLICATION ABSTRACT) |
| doi_str_mv | 10.1007/s10856-007-3223-2 |
| format | Article |
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A baseline binding and release study of F XIII from the scaffold showed a continuous release of 18% of the total dose after 48 h. The main study consisted of 18 adult sheep with cylindrical defects in both tibiae. The defects were filled with a β-TCP cylinder impregnated either with bone marrow, venous blood, F XIII or sheep were treated with 1250 IU F XIII intravenously over 14 days (n = 4 in each group). The defects were left open in two sheep. QCT and histology was performed after 6 and 12 weeks. The best bone ingrowth was seen after 6 weeks in the bone marrow group and after 12 weeks in the local F XIII group. The highest ingrowth on the inside of the cylinder proving the osteopromoting potential of F XIII was found in the local F XIII group. In our opinion F XIII is a good and readily available osteopromoting agent which can be used with β-TCP in cases of bone deficit to promote bone regeneration. 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In our opinion F XIII is a good and readily available osteopromoting agent which can be used with β-TCP in cases of bone deficit to promote bone regeneration. 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Becker, Stephan</au><au>Maissen, Otto</au><au>Ponomarev, Igor</au><au>Stoll, Thierry</au><au>Meury, Thomas</au><au>Sprecher, Christoph</au><au>Alini, Mauro</au><au>Wilke, Ingo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteopromotion with a plasmatransglutaminase on a [beta]-TCP ceramic</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><date>2008-02-01</date><risdate>2008</risdate><volume>19</volume><issue>2</issue><spage>659</spage><pages>659-</pages><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>We investigated the osteopromotive properties of plasmatransglutaminase (F XIII), bone marrow and venous blood on a resorbable β-tricalcium phosphate (β-TCP) scaffold. 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(PUBLICATION ABSTRACT)</abstract><cop>London</cop><pub>Springer Nature B.V</pub><doi>10.1007/s10856-007-3223-2</doi></addata></record> |
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| subjects | Biomedical materials Bone marrow Ceramics Materials science Plasma Studies |
| title | Osteopromotion with a plasmatransglutaminase on a [beta]-TCP ceramic |
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