Increased endostatin/collagen XVIII expression correlates with elevated VEGF level and poor prognosis in hepatocellular carcinoma
Liver is the primary source for collagen XVIII, the precursor of angiogenesis inhibitor, endostatin. However, the role of endostatin/collagen XVIII expression during liver carcinogenesis remains elusive. Therefore, we studied its expression in five hepatoma cell lines and 105 hepatocellular carcinom...
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| Veröffentlicht in: | Modern pathology 2005-05, Vol.18 (5), p.663-672 |
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| description | Liver is the primary source for collagen XVIII, the precursor of angiogenesis inhibitor, endostatin. However, the role of endostatin/collagen XVIII expression during liver carcinogenesis remains elusive. Therefore, we studied its expression in five hepatoma cell lines and 105 hepatocellular carcinoma specimens. The poorly differentiated hepatoma cell lines exhibited increased endostatin/collagen XVIII levels compared with the well-differentiated ones. In hepatoma tissues, endostatin/collagen XVIII expression was detected in various types of liver cells and was significantly stronger in adjacent nontumor tissues than that in tumors (P0.05). Kaplan–Meier analysis showed that patients with higher endostatin/collagen XVIII expression had significantly shorter overall survival (P=0.011) and disease-free survival (P=0.0034). Moreover, endostatin/collagen XVIII level was an independent prognostic factor for tumor recurrence (P=0.034) by multivariate analysis. In conclusion, increased endostatin/collagen XVIII expression correlated with hepatoma progression and predicted poor prognosis for patients with hepatocellular carcinoma. |
| doi_str_mv | 10.1038/modpathol.3800336 |
| format | Article |
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However, the role of endostatin/collagen XVIII expression during liver carcinogenesis remains elusive. Therefore, we studied its expression in five hepatoma cell lines and 105 hepatocellular carcinoma specimens. The poorly differentiated hepatoma cell lines exhibited increased endostatin/collagen XVIII levels compared with the well-differentiated ones. In hepatoma tissues, endostatin/collagen XVIII expression was detected in various types of liver cells and was significantly stronger in adjacent nontumor tissues than that in tumors (P<0.001). Endostatin/collagen XVIII expression in nontumor tissues correlated with tumor stages (P=0.014) and expression of vascular endothelial growth factor (P=0.007), but not the stages of hepatic fibrosis (P>0.05). Kaplan–Meier analysis showed that patients with higher endostatin/collagen XVIII expression had significantly shorter overall survival (P=0.011) and disease-free survival (P=0.0034). Moreover, endostatin/collagen XVIII level was an independent prognostic factor for tumor recurrence (P=0.034) by multivariate analysis. In conclusion, increased endostatin/collagen XVIII expression correlated with hepatoma progression and predicted poor prognosis for patients with hepatocellular carcinoma.</description><identifier>ISSN: 0893-3952</identifier><identifier>EISSN: 1530-0285</identifier><identifier>DOI: 10.1038/modpathol.3800336</identifier><identifier>PMID: 15605080</identifier><identifier>CODEN: MODPEO</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Adult ; Aged ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - pathology ; Cell Line, Tumor ; Collagen Type XVIII - genetics ; Collagen Type XVIII - metabolism ; collagen XVIII ; endostatin ; Endostatins - genetics ; Endostatins - metabolism ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; HeLa Cells ; hepatocellular carcinoma ; Humans ; Immunohistochemistry ; Laboratory Medicine ; Liver Neoplasms - genetics ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate Analysis ; Neoplasm Recurrence, Local ; Neoplasm Staging ; original-article ; Pathology ; Prognosis ; Reverse Transcriptase Polymerase Chain Reaction - methods ; RNA, Neoplasm - genetics ; RNA, Neoplasm - metabolism ; Survival Analysis ; Vascular Endothelial Growth Factor A - metabolism ; VEGF</subject><ispartof>Modern pathology, 2005-05, Vol.18 (5), p.663-672</ispartof><rights>2005 United States & Canadian Academy of Pathology</rights><rights>United States and Canadian Academy of Pathology, Inc. 2005</rights><rights>Copyright Nature Publishing Group May 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-14ede5dfd96b44b683645549fccbb5b02ce2e50d887320250896c06098f8eaaa3</citedby><cites>FETCH-LOGICAL-c464t-14ede5dfd96b44b683645549fccbb5b02ce2e50d887320250896c06098f8eaaa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15605080$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Tsung-Hui</creatorcontrib><creatorcontrib>Huang, Chao-Cheng</creatorcontrib><creatorcontrib>Wu, Chia-Ling</creatorcontrib><creatorcontrib>Lin, Pey-Ru</creatorcontrib><creatorcontrib>Liu, Shang-Yun</creatorcontrib><creatorcontrib>Lin, Jui-Wei</creatorcontrib><creatorcontrib>Chuang, Jiin-Haur</creatorcontrib><creatorcontrib>Tai, Ming Hong</creatorcontrib><title>Increased endostatin/collagen XVIII expression correlates with elevated VEGF level and poor prognosis in hepatocellular carcinoma</title><title>Modern pathology</title><addtitle>Mod Pathol</addtitle><addtitle>Mod Pathol</addtitle><description>Liver is the primary source for collagen XVIII, the precursor of angiogenesis inhibitor, endostatin. However, the role of endostatin/collagen XVIII expression during liver carcinogenesis remains elusive. Therefore, we studied its expression in five hepatoma cell lines and 105 hepatocellular carcinoma specimens. The poorly differentiated hepatoma cell lines exhibited increased endostatin/collagen XVIII levels compared with the well-differentiated ones. In hepatoma tissues, endostatin/collagen XVIII expression was detected in various types of liver cells and was significantly stronger in adjacent nontumor tissues than that in tumors (P<0.001). Endostatin/collagen XVIII expression in nontumor tissues correlated with tumor stages (P=0.014) and expression of vascular endothelial growth factor (P=0.007), but not the stages of hepatic fibrosis (P>0.05). Kaplan–Meier analysis showed that patients with higher endostatin/collagen XVIII expression had significantly shorter overall survival (P=0.011) and disease-free survival (P=0.0034). Moreover, endostatin/collagen XVIII level was an independent prognostic factor for tumor recurrence (P=0.034) by multivariate analysis. In conclusion, increased endostatin/collagen XVIII expression correlated with hepatoma progression and predicted poor prognosis for patients with hepatocellular carcinoma.</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cell Line, Tumor</subject><subject>Collagen Type XVIII - genetics</subject><subject>Collagen Type XVIII - metabolism</subject><subject>collagen XVIII</subject><subject>endostatin</subject><subject>Endostatins - genetics</subject><subject>Endostatins - metabolism</subject><subject>Female</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>HeLa Cells</subject><subject>hepatocellular carcinoma</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Laboratory Medicine</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neoplasm Staging</subject><subject>original-article</subject><subject>Pathology</subject><subject>Prognosis</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - methods</subject><subject>RNA, Neoplasm - genetics</subject><subject>RNA, Neoplasm - metabolism</subject><subject>Survival Analysis</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>VEGF</subject><issn>0893-3952</issn><issn>1530-0285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kE9P3DAQxS1UBNuFD9BLZfUeGNtx6qinCvEnElIvgLhFjj3ZNfLaqZ2l5dhvjtGuyo3LjEZ-7834R8gXBmcMhDrfRDvpeR39mVAAQjQHZMGkgAq4kp_IAlQrKtFKfkw-5_wEwGqp-BE5ZrIBCQoW5F8XTEKd0VIMNuZZzy6cm-i9XmGgjw9d11H8OyXM2cVATUwJvZ4x0z9uXlP0-FwmSx8ur69oGdBTHSydYkx0SnEVYnaZukDXWG6NBr3fep2o0cm4EDf6hByO2mc83fclub-6vLu4qW5_XXcXP28rUzf1XLEaLUo72rYZ6npolGhqKet2NGYY5ADcIEcJVqnvggMvv2sbAw20alSotRZL8m2XW676vcU8909xm0JZ2XPOeIkrZUnYTmRSzDnh2E_JbXR66Rn0b8z7_8z7PfPi-boP3g4btO-OPeQi4DtBLk9hhel980epP3YmLEyeXTFl4zAYtC6hmXsb3QfuVze2p28</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Hu, Tsung-Hui</creator><creator>Huang, Chao-Cheng</creator><creator>Wu, Chia-Ling</creator><creator>Lin, Pey-Ru</creator><creator>Liu, Shang-Yun</creator><creator>Lin, Jui-Wei</creator><creator>Chuang, Jiin-Haur</creator><creator>Tai, Ming Hong</creator><general>Elsevier Inc</general><general>Nature Publishing Group US</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20050501</creationdate><title>Increased endostatin/collagen XVIII expression correlates with elevated VEGF level and poor prognosis in hepatocellular carcinoma</title><author>Hu, Tsung-Hui ; Huang, Chao-Cheng ; Wu, Chia-Ling ; Lin, Pey-Ru ; Liu, Shang-Yun ; Lin, Jui-Wei ; Chuang, Jiin-Haur ; Tai, Ming Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-14ede5dfd96b44b683645549fccbb5b02ce2e50d887320250896c06098f8eaaa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Cell Line, Tumor</topic><topic>Collagen Type XVIII - genetics</topic><topic>Collagen Type XVIII - metabolism</topic><topic>collagen XVIII</topic><topic>endostatin</topic><topic>Endostatins - genetics</topic><topic>Endostatins - metabolism</topic><topic>Female</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>HeLa Cells</topic><topic>hepatocellular carcinoma</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Laboratory Medicine</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - pathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Recurrence, Local</topic><topic>Neoplasm Staging</topic><topic>original-article</topic><topic>Pathology</topic><topic>Prognosis</topic><topic>Reverse Transcriptase Polymerase Chain Reaction - methods</topic><topic>RNA, Neoplasm - genetics</topic><topic>RNA, Neoplasm - metabolism</topic><topic>Survival Analysis</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><topic>VEGF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Tsung-Hui</creatorcontrib><creatorcontrib>Huang, Chao-Cheng</creatorcontrib><creatorcontrib>Wu, Chia-Ling</creatorcontrib><creatorcontrib>Lin, Pey-Ru</creatorcontrib><creatorcontrib>Liu, Shang-Yun</creatorcontrib><creatorcontrib>Lin, Jui-Wei</creatorcontrib><creatorcontrib>Chuang, Jiin-Haur</creatorcontrib><creatorcontrib>Tai, Ming Hong</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Modern pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Tsung-Hui</au><au>Huang, Chao-Cheng</au><au>Wu, Chia-Ling</au><au>Lin, Pey-Ru</au><au>Liu, Shang-Yun</au><au>Lin, Jui-Wei</au><au>Chuang, Jiin-Haur</au><au>Tai, Ming Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased endostatin/collagen XVIII expression correlates with elevated VEGF level and poor prognosis in hepatocellular carcinoma</atitle><jtitle>Modern pathology</jtitle><stitle>Mod Pathol</stitle><addtitle>Mod Pathol</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>18</volume><issue>5</issue><spage>663</spage><epage>672</epage><pages>663-672</pages><issn>0893-3952</issn><eissn>1530-0285</eissn><coden>MODPEO</coden><abstract>Liver is the primary source for collagen XVIII, the precursor of angiogenesis inhibitor, endostatin. However, the role of endostatin/collagen XVIII expression during liver carcinogenesis remains elusive. Therefore, we studied its expression in five hepatoma cell lines and 105 hepatocellular carcinoma specimens. The poorly differentiated hepatoma cell lines exhibited increased endostatin/collagen XVIII levels compared with the well-differentiated ones. In hepatoma tissues, endostatin/collagen XVIII expression was detected in various types of liver cells and was significantly stronger in adjacent nontumor tissues than that in tumors (P<0.001). Endostatin/collagen XVIII expression in nontumor tissues correlated with tumor stages (P=0.014) and expression of vascular endothelial growth factor (P=0.007), but not the stages of hepatic fibrosis (P>0.05). Kaplan–Meier analysis showed that patients with higher endostatin/collagen XVIII expression had significantly shorter overall survival (P=0.011) and disease-free survival (P=0.0034). Moreover, endostatin/collagen XVIII level was an independent prognostic factor for tumor recurrence (P=0.034) by multivariate analysis. In conclusion, increased endostatin/collagen XVIII expression correlated with hepatoma progression and predicted poor prognosis for patients with hepatocellular carcinoma.</abstract><cop>New York</cop><pub>Elsevier Inc</pub><pmid>15605080</pmid><doi>10.1038/modpathol.3800336</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor Collagen Type XVIII - genetics Collagen Type XVIII - metabolism collagen XVIII endostatin Endostatins - genetics Endostatins - metabolism Female Gene Expression Profiling Gene Expression Regulation, Neoplastic HeLa Cells hepatocellular carcinoma Humans Immunohistochemistry Laboratory Medicine Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Medicine Medicine & Public Health Middle Aged Multivariate Analysis Neoplasm Recurrence, Local Neoplasm Staging original-article Pathology Prognosis Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Neoplasm - genetics RNA, Neoplasm - metabolism Survival Analysis Vascular Endothelial Growth Factor A - metabolism VEGF |
| title | Increased endostatin/collagen XVIII expression correlates with elevated VEGF level and poor prognosis in hepatocellular carcinoma |
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