Embolized Crospovidone (poly[N-vinyl-2-pyrrolidone]) in the Lungs of Intravenous Drug Users

Crospovidone is an insoluble polymer of N-vinyl-2-pyrrolidone that is used as a disintegrant in pharmaceutical tablets. It can potentially embolize to the lung when aqueous tablet suspensions are injected intravenously. In this report, we identified embolized crospovidone in autopsy-derived lung tis...

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Veröffentlicht in:	Modern pathology 2003-04, Vol.16 (4), p.286-292
Hauptverfasser:	Ganesan, Santhi, Felo, Joseph, Saldana, Mario, Kalasinsky, Victor F, Lewin-Smith, Michael R, Tomashefski, Joseph F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Blood Vessels - pathology Blood Vessels - ultrastructure Crospovidone Female Foreign body emboli Foreign-Body Reaction - etiology Humans Hydromorphone - administration & dosage Hydromorphone - adverse effects Intravenous drug use Laboratory Medicine Lung Diseases - etiology Lung Diseases - pathology Male Medicine Medicine & Public Health Microscopy, Electron N-vinyl-2-pyrrolidone Narcotics - administration & dosage Narcotics - adverse effects original-article Pathology Pharmaceutic Aids - adverse effects Polyvinylpyrrolidone Povidone - adverse effects Pulmonary Embolism - pathology Spectrophotometry, Infrared Substance Abuse, Intravenous - complications Substance Abuse, Intravenous - pathology Tablets
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