Hyperbaric Oxygen Therapy of Cerebral Ischemia

Background: Hyperbaric oxygen (HBO) therapy of cerebral ischemia has been evaluated in a number of human and animal studies; however, there is presently no consensus on its efficacy. Methods: We present a review of animal and human studies on HBO therapy of cerebral ischemia as well as present poten...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cerebrovascular diseases (Basel, Switzerland) Switzerland), 2005-01, Vol.20 (6), p.417-426
Hauptverfasser: Helms, Ann K., Whelan, Harry T., Torbey, Michel T.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 426
container_issue 6
container_start_page 417
container_title Cerebrovascular diseases (Basel, Switzerland)
container_volume 20
creator Helms, Ann K.
Whelan, Harry T.
Torbey, Michel T.
description Background: Hyperbaric oxygen (HBO) therapy of cerebral ischemia has been evaluated in a number of human and animal studies; however, there is presently no consensus on its efficacy. Methods: We present a review of animal and human studies on HBO therapy of cerebral ischemia as well as present potential mechanisms of action of HBO. Results: Animal studies of HBO have shown promise by reducing infarct size and improving neurologic outcome. HBO has also been shown to inhibit inflammation and apoptosis after cerebral ischemia. Early reports in humans also suggested benefit in stroke patients treated with HBO. Recent randomized, controlled human studies, however, have not shown benefit, although all were limited by small sample size. Important differences between animal and human studies suggest HBO might be more effective in stroke within the first few hours and at a pressure of 2–3 ATA. Conclusions: The clinical usefulness of HBO in the treatment of cerebral ischemia is not yet certain. Attention to emerging pathophysiologic data should be taken into consideration in design of any future clinical trials of HBO in acute ischemic stroke.
doi_str_mv 10.1159/000088979
format Article
fullrecord <record><control><sourceid>proquest_karge</sourceid><recordid>TN_cdi_proquest_journals_221227978</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68811780</sourcerecordid><originalsourceid>FETCH-LOGICAL-c361t-1e41733caa6a79eefb5602992d036525055acea14d8db377ea2c8fd4369311293</originalsourceid><addsrcrecordid>eNqF0E1Lw0AQBuBFFFurB8-CBA-Ch9Sd3ezXUYofhUIv9Rw2yaRNTZu624D5966kVPDiXGYOzwzMS8g10DGAMI80lNZGmRMyhIRBbJSWp2GmIMKs6IBceL8OSoKGczIAyTjViRiS8Vu3Q5dZV-XR_Ktb4jZarNDZXRc1ZTRBh5mzdTT1-Qo3lb0kZ6WtPV4d-oi8vzwvJm_xbP46nTzN4pxL2MeACSjOc2ulVQaxzISkzBhWUC4FE1QIm6OFpNBFxpVCy3JdFgmXhgMww0fkvr-7c81ni36fbiqfY13bLTatT6XWAErTfyGjhspEsADv_sB107pteCJlDBhTIbOAHnqUu8Z7h2W6c9XGui4Fmv5EnR6jDvb2cLDNNlj8ykO2Adz04MO6Jboj6Ne_AepGflo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>221227978</pqid></control><display><type>article</type><title>Hyperbaric Oxygen Therapy of Cerebral Ischemia</title><source>MEDLINE</source><source>Karger Journals</source><creator>Helms, Ann K. ; Whelan, Harry T. ; Torbey, Michel T.</creator><creatorcontrib>Helms, Ann K. ; Whelan, Harry T. ; Torbey, Michel T.</creatorcontrib><description>Background: Hyperbaric oxygen (HBO) therapy of cerebral ischemia has been evaluated in a number of human and animal studies; however, there is presently no consensus on its efficacy. Methods: We present a review of animal and human studies on HBO therapy of cerebral ischemia as well as present potential mechanisms of action of HBO. Results: Animal studies of HBO have shown promise by reducing infarct size and improving neurologic outcome. HBO has also been shown to inhibit inflammation and apoptosis after cerebral ischemia. Early reports in humans also suggested benefit in stroke patients treated with HBO. Recent randomized, controlled human studies, however, have not shown benefit, although all were limited by small sample size. Important differences between animal and human studies suggest HBO might be more effective in stroke within the first few hours and at a pressure of 2–3 ATA. Conclusions: The clinical usefulness of HBO in the treatment of cerebral ischemia is not yet certain. Attention to emerging pathophysiologic data should be taken into consideration in design of any future clinical trials of HBO in acute ischemic stroke.</description><identifier>ISSN: 1015-9770</identifier><identifier>EISSN: 1421-9786</identifier><identifier>DOI: 10.1159/000088979</identifier><identifier>PMID: 16230845</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Animals ; Brain Ischemia - therapy ; Clinical Trials as Topic ; Humans ; Hyperbaric Oxygenation - adverse effects ; Hyperbaric Oxygenation - trends ; Review ; Stroke - therapy</subject><ispartof>Cerebrovascular diseases (Basel, Switzerland), 2005-01, Vol.20 (6), p.417-426</ispartof><rights>2005 S. Karger AG, Basel</rights><rights>Copyright (c) 2005 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-1e41733caa6a79eefb5602992d036525055acea14d8db377ea2c8fd4369311293</citedby><cites>FETCH-LOGICAL-c361t-1e41733caa6a79eefb5602992d036525055acea14d8db377ea2c8fd4369311293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,2423,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16230845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Helms, Ann K.</creatorcontrib><creatorcontrib>Whelan, Harry T.</creatorcontrib><creatorcontrib>Torbey, Michel T.</creatorcontrib><title>Hyperbaric Oxygen Therapy of Cerebral Ischemia</title><title>Cerebrovascular diseases (Basel, Switzerland)</title><addtitle>Cerebrovasc Dis</addtitle><description>Background: Hyperbaric oxygen (HBO) therapy of cerebral ischemia has been evaluated in a number of human and animal studies; however, there is presently no consensus on its efficacy. Methods: We present a review of animal and human studies on HBO therapy of cerebral ischemia as well as present potential mechanisms of action of HBO. Results: Animal studies of HBO have shown promise by reducing infarct size and improving neurologic outcome. HBO has also been shown to inhibit inflammation and apoptosis after cerebral ischemia. Early reports in humans also suggested benefit in stroke patients treated with HBO. Recent randomized, controlled human studies, however, have not shown benefit, although all were limited by small sample size. Important differences between animal and human studies suggest HBO might be more effective in stroke within the first few hours and at a pressure of 2–3 ATA. Conclusions: The clinical usefulness of HBO in the treatment of cerebral ischemia is not yet certain. Attention to emerging pathophysiologic data should be taken into consideration in design of any future clinical trials of HBO in acute ischemic stroke.</description><subject>Animals</subject><subject>Brain Ischemia - therapy</subject><subject>Clinical Trials as Topic</subject><subject>Humans</subject><subject>Hyperbaric Oxygenation - adverse effects</subject><subject>Hyperbaric Oxygenation - trends</subject><subject>Review</subject><subject>Stroke - therapy</subject><issn>1015-9770</issn><issn>1421-9786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqF0E1Lw0AQBuBFFFurB8-CBA-Ch9Sd3ezXUYofhUIv9Rw2yaRNTZu624D5966kVPDiXGYOzwzMS8g10DGAMI80lNZGmRMyhIRBbJSWp2GmIMKs6IBceL8OSoKGczIAyTjViRiS8Vu3Q5dZV-XR_Ktb4jZarNDZXRc1ZTRBh5mzdTT1-Qo3lb0kZ6WtPV4d-oi8vzwvJm_xbP46nTzN4pxL2MeACSjOc2ulVQaxzISkzBhWUC4FE1QIm6OFpNBFxpVCy3JdFgmXhgMww0fkvr-7c81ni36fbiqfY13bLTatT6XWAErTfyGjhspEsADv_sB107pteCJlDBhTIbOAHnqUu8Z7h2W6c9XGui4Fmv5EnR6jDvb2cLDNNlj8ykO2Adz04MO6Jboj6Ne_AepGflo</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Helms, Ann K.</creator><creator>Whelan, Harry T.</creator><creator>Torbey, Michel T.</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20050101</creationdate><title>Hyperbaric Oxygen Therapy of Cerebral Ischemia</title><author>Helms, Ann K. ; Whelan, Harry T. ; Torbey, Michel T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-1e41733caa6a79eefb5602992d036525055acea14d8db377ea2c8fd4369311293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Brain Ischemia - therapy</topic><topic>Clinical Trials as Topic</topic><topic>Humans</topic><topic>Hyperbaric Oxygenation - adverse effects</topic><topic>Hyperbaric Oxygenation - trends</topic><topic>Review</topic><topic>Stroke - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Helms, Ann K.</creatorcontrib><creatorcontrib>Whelan, Harry T.</creatorcontrib><creatorcontrib>Torbey, Michel T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Cerebrovascular diseases (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Helms, Ann K.</au><au>Whelan, Harry T.</au><au>Torbey, Michel T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperbaric Oxygen Therapy of Cerebral Ischemia</atitle><jtitle>Cerebrovascular diseases (Basel, Switzerland)</jtitle><addtitle>Cerebrovasc Dis</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>20</volume><issue>6</issue><spage>417</spage><epage>426</epage><pages>417-426</pages><issn>1015-9770</issn><eissn>1421-9786</eissn><abstract>Background: Hyperbaric oxygen (HBO) therapy of cerebral ischemia has been evaluated in a number of human and animal studies; however, there is presently no consensus on its efficacy. Methods: We present a review of animal and human studies on HBO therapy of cerebral ischemia as well as present potential mechanisms of action of HBO. Results: Animal studies of HBO have shown promise by reducing infarct size and improving neurologic outcome. HBO has also been shown to inhibit inflammation and apoptosis after cerebral ischemia. Early reports in humans also suggested benefit in stroke patients treated with HBO. Recent randomized, controlled human studies, however, have not shown benefit, although all were limited by small sample size. Important differences between animal and human studies suggest HBO might be more effective in stroke within the first few hours and at a pressure of 2–3 ATA. Conclusions: The clinical usefulness of HBO in the treatment of cerebral ischemia is not yet certain. Attention to emerging pathophysiologic data should be taken into consideration in design of any future clinical trials of HBO in acute ischemic stroke.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>16230845</pmid><doi>10.1159/000088979</doi><tpages>10</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1015-9770
ispartof Cerebrovascular diseases (Basel, Switzerland), 2005-01, Vol.20 (6), p.417-426
issn 1015-9770
1421-9786
language eng
recordid cdi_proquest_journals_221227978
source MEDLINE; Karger Journals
subjects Animals
Brain Ischemia - therapy
Clinical Trials as Topic
Humans
Hyperbaric Oxygenation - adverse effects
Hyperbaric Oxygenation - trends
Review
Stroke - therapy
title Hyperbaric Oxygen Therapy of Cerebral Ischemia
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T07%3A37%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_karge&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hyperbaric%20Oxygen%20Therapy%20of%20Cerebral%20Ischemia&rft.jtitle=Cerebrovascular%20diseases%20(Basel,%20Switzerland)&rft.au=Helms,%20Ann%20K.&rft.date=2005-01-01&rft.volume=20&rft.issue=6&rft.spage=417&rft.epage=426&rft.pages=417-426&rft.issn=1015-9770&rft.eissn=1421-9786&rft_id=info:doi/10.1159/000088979&rft_dat=%3Cproquest_karge%3E68811780%3C/proquest_karge%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=221227978&rft_id=info:pmid/16230845&rfr_iscdi=true