Clinical Trials in Pediatric Traumatic Brain Injury: Unique Challenges and Potential Responses
In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our...
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| Veröffentlicht in: | Developmental neuroscience 2006-01, Vol.28 (4-5), p.276-290 |
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| container_issue | 4-5 |
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| container_title | Developmental neuroscience |
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| creator | Natale, JoAnne E. Joseph, Jill G. Pretzlaff, Robert K. Silber, Tomas J. Guerguerian, Anne-Marie |
| description | In order to optimize pediatric traumatic brain injury translational and clinical research, scientific and ethical challenges need to be recognized and addressed. Having recently conducted a multisite phase II safety/feasibility trial of magnesium sulfate as a neuroprotective agent, we supplement our own experience by a mini review of similar studies, identifying challenges and possible responses from the perspective of families, investigators, funding agencies and society. |
| doi_str_mv | 10.1159/000094154 |
| format | Article |
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| source | MEDLINE; Karger Journals |
| subjects | Brain Injuries - psychology Brain Injuries - therapy Caregivers - psychology Caregivers - statistics & numerical data Caregivers - trends Child Clinical Protocols - standards Clinical Research Clinical Trials as Topic - ethics Clinical Trials as Topic - standards Clinical Trials as Topic - trends Family - psychology Humans Informed Consent - psychology Informed Consent - standards Outcome Assessment (Health Care) - standards Outcome Assessment (Health Care) - trends Patient Selection - ethics Pediatrics - ethics Pediatrics - standards Pediatrics - trends Practice Guidelines as Topic - standards Research Support as Topic - statistics & numerical data Research Support as Topic - trends |
| title | Clinical Trials in Pediatric Traumatic Brain Injury: Unique Challenges and Potential Responses |
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