Utilizing Nottingham Prognostic Index in microarray gene expression profiling of breast carcinomas

We report a novel approach to gene expression profiling using the Nottingham Prognostic Index (NPI) to stratify 26 patients with invasive breast carcinoma. As an aggregate index of parameters reflecting metastatic potential, growth rate, and genetic instability the NPI has distinct advantages over o...

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Veröffentlicht in:	Modern pathology 2004-07, Vol.17 (7), p.756-764
Hauptverfasser:	Miller, Dylan V, Leontovich, Alexey A, Lingle, Wilma L, Suman, Vera J, Mertens, Maureen L, Lillie, James, Ingalls, Kimberly A, Perez, Edith A, Ingle, James N, Couch, Fergus J, Visscher, Daniel W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antigens, Neoplasm - analysis Antigens, Neoplasm - genetics Breast cancer breast neoplasms Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms, Male - genetics Breast Neoplasms, Male - metabolism Breast Neoplasms, Male - pathology carcinoma, infiltrating duct cDNA microarray Chromosome Aberrations Cluster Analysis Correlation analysis DNA-Binding Proteins - analysis DNA-Binding Proteins - genetics Expressed Sequence Tags Female GATA3 Transcription Factor Gene Amplification Gene expression gene expression profiling Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Lymphatic system Male Metastasis Middle Aged Nottingham Prognostic Index Oligonucleotide Array Sequence Analysis - methods Oncology Pathology Prognosis Severity of Illness Index Smad4 Protein Trans-Activators - analysis Trans-Activators - genetics Tumors
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