Prevalence and risk factors for epiretinal membrane: the Singapore Epidemiology of Eye Disease study
To examine prevalence and risk factors of epiretinal membrane (ERM) in a large, contemporary, multiethnic Asian population. Combined analysis of three population-based studies of eye diseases, with a total of 9799 Chinese, Malays and Indians residing in the general communities of Singapore. A compre...
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| Veröffentlicht in: | British journal of ophthalmology 2017-03, Vol.101 (3), p.371 |
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| container_title | British journal of ophthalmology |
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| creator | Cheung, Ning Tan, Shu-Pei Lee, Shu Yen Cheung, Gemmy Chui Ming Tan, Gavin Kumar, Neelam Cheng, Ching-Yu Wong, Tien Yin |
| description | To examine prevalence and risk factors of epiretinal membrane (ERM) in a large, contemporary, multiethnic Asian population.
Combined analysis of three population-based studies of eye diseases, with a total of 9799 Chinese, Malays and Indians residing in the general communities of Singapore. A comprehensive ophthalmic examination, interviews and laboratory blood tests were performed to assess potential risk factors. Digital retinal photographs were used to assess ERM according to a standardised protocol. ERM was classified into cellophane macular reflex (CMR) and/or preretinal macular fibrosis (PMF), and also as primary or secondary (in eyes with other retinal pathology or a history of cataract surgery).
The age-standardised and ethnicity-standardised prevalence was 12.1% for any ERM, 6.8% for CMR, 6.7% for PMF and 2.8% for bilateral ERM. ERM prevalence was higher in Chinese (13.0%) compared with Malays (7.9%) or Indians (8.7%). In multivariate analysis, significant factors associated with primary ERM were older age (OR 1.08 per year increase; p |
| doi_str_mv | 10.1136/bjophthalmol-2016-308563 |
| format | Article |
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Combined analysis of three population-based studies of eye diseases, with a total of 9799 Chinese, Malays and Indians residing in the general communities of Singapore. A comprehensive ophthalmic examination, interviews and laboratory blood tests were performed to assess potential risk factors. Digital retinal photographs were used to assess ERM according to a standardised protocol. ERM was classified into cellophane macular reflex (CMR) and/or preretinal macular fibrosis (PMF), and also as primary or secondary (in eyes with other retinal pathology or a history of cataract surgery).
The age-standardised and ethnicity-standardised prevalence was 12.1% for any ERM, 6.8% for CMR, 6.7% for PMF and 2.8% for bilateral ERM. ERM prevalence was higher in Chinese (13.0%) compared with Malays (7.9%) or Indians (8.7%). In multivariate analysis, significant factors associated with primary ERM were older age (OR 1.08 per year increase; p<0.01), Chinese ethnicity (OR 1.60 vs Indians; p<0.01; OR 1.39 vs Malays; p<0.01), smoking (OR 0.70; p=0.01), longer axial length (OR 1.07 per mm increase; p=0.03) and cataract (OR 0.64; p<0.01). Significant factors independently associated with secondary ERM were older age (OR 1.05; p<0.01), cataract surgery (OR 10.6; p<0.01) and diabetic retinopathy (OR 2.48; p<0.01).
ERM is common in Asians, particularly among Chinese. Older age is the most consistent risk factor for any ERM, and previous cataract surgery and diabetic retinopathy are the strongest risk factors for secondary ERM.]]></description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjophthalmol-2016-308563</identifier><identifier>PMID: 27343209</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Adult ; Age ; Age Distribution ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group - statistics & numerical data ; Asian people ; Blood pressure ; Cataracts ; Diabetes ; Diabetic retinopathy ; Epidemiology ; Epiretinal Membrane - epidemiology ; Eye diseases ; Eye surgery ; Family medical history ; Female ; Humans ; Laboratories ; Macular degeneration ; Male ; Membranes ; Middle Aged ; Minority & ethnic groups ; Ophthalmology ; Population ; Prevalence ; Quality of life ; Response rates ; Risk Factors ; Singapore - epidemiology ; Socioeconomic factors ; Veins & arteries ; Visual impairment</subject><ispartof>British journal of ophthalmology, 2017-03, Vol.101 (3), p.371</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c310t-dbc53e870c71a1842af67e254439802b0352111d875935cc268d8f552287ff733</citedby><cites>FETCH-LOGICAL-c310t-dbc53e870c71a1842af67e254439802b0352111d875935cc268d8f552287ff733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27343209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheung, Ning</creatorcontrib><creatorcontrib>Tan, Shu-Pei</creatorcontrib><creatorcontrib>Lee, Shu Yen</creatorcontrib><creatorcontrib>Cheung, Gemmy Chui Ming</creatorcontrib><creatorcontrib>Tan, Gavin</creatorcontrib><creatorcontrib>Kumar, Neelam</creatorcontrib><creatorcontrib>Cheng, Ching-Yu</creatorcontrib><creatorcontrib>Wong, Tien Yin</creatorcontrib><title>Prevalence and risk factors for epiretinal membrane: the Singapore Epidemiology of Eye Disease study</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description><![CDATA[To examine prevalence and risk factors of epiretinal membrane (ERM) in a large, contemporary, multiethnic Asian population.
Combined analysis of three population-based studies of eye diseases, with a total of 9799 Chinese, Malays and Indians residing in the general communities of Singapore. A comprehensive ophthalmic examination, interviews and laboratory blood tests were performed to assess potential risk factors. Digital retinal photographs were used to assess ERM according to a standardised protocol. ERM was classified into cellophane macular reflex (CMR) and/or preretinal macular fibrosis (PMF), and also as primary or secondary (in eyes with other retinal pathology or a history of cataract surgery).
The age-standardised and ethnicity-standardised prevalence was 12.1% for any ERM, 6.8% for CMR, 6.7% for PMF and 2.8% for bilateral ERM. ERM prevalence was higher in Chinese (13.0%) compared with Malays (7.9%) or Indians (8.7%). In multivariate analysis, significant factors associated with primary ERM were older age (OR 1.08 per year increase; p<0.01), Chinese ethnicity (OR 1.60 vs Indians; p<0.01; OR 1.39 vs Malays; p<0.01), smoking (OR 0.70; p=0.01), longer axial length (OR 1.07 per mm increase; p=0.03) and cataract (OR 0.64; p<0.01). Significant factors independently associated with secondary ERM were older age (OR 1.05; p<0.01), cataract surgery (OR 10.6; p<0.01) and diabetic retinopathy (OR 2.48; p<0.01).
ERM is common in Asians, particularly among Chinese. Older age is the most consistent risk factor for any ERM, and previous cataract surgery and diabetic retinopathy are the strongest risk factors for secondary ERM.]]></description><subject>Adult</subject><subject>Age</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Asian Continental Ancestry Group - statistics & numerical data</subject><subject>Asian people</subject><subject>Blood pressure</subject><subject>Cataracts</subject><subject>Diabetes</subject><subject>Diabetic retinopathy</subject><subject>Epidemiology</subject><subject>Epiretinal Membrane - epidemiology</subject><subject>Eye diseases</subject><subject>Eye surgery</subject><subject>Family medical history</subject><subject>Female</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Macular degeneration</subject><subject>Male</subject><subject>Membranes</subject><subject>Middle Aged</subject><subject>Minority & ethnic groups</subject><subject>Ophthalmology</subject><subject>Population</subject><subject>Prevalence</subject><subject>Quality of life</subject><subject>Response rates</subject><subject>Risk Factors</subject><subject>Singapore - epidemiology</subject><subject>Socioeconomic factors</subject><subject>Veins & arteries</subject><subject>Visual impairment</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpNkF1LwzAUhoMobk7_ggS8ruajaVLvZM4PGCio1yFtTrbOtqlJK-zf27EpXh3O4X3OOTwIYUquKeXZTbHx3bpfm7rxdcIIzRJOlMj4EZrSNFPjSObHaEoIkQmlGZ2gsxg3Y8syKk_RhEmeckbyKbKvAb5NDW0J2LQWhyp-YmfK3oeInQ8YuipAX7Wmxg00RTAt3OJ-Dfitalem8wHwoqssNJWv_WqLvcOLLeD7KoKJgGM_2O05OnGmjnBxqDP08bB4nz8ly5fH5_ndMik5JX1ii1JwUJKUkhqqUmZcJoGJNOW5IqwgXDBKqVVS5FyUJcuUVU4IxpR0TnI-Q1f7vV3wXwPEXm_8EMbXo2YjSVKR5mRMqX2qDD7GAE53oWpM2GpK9E6v_q9X7_Tqvd4RvTwcGIoG7B_465P_AMWVeX8</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Cheung, Ning</creator><creator>Tan, Shu-Pei</creator><creator>Lee, Shu Yen</creator><creator>Cheung, Gemmy Chui Ming</creator><creator>Tan, Gavin</creator><creator>Kumar, Neelam</creator><creator>Cheng, Ching-Yu</creator><creator>Wong, Tien Yin</creator><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20170301</creationdate><title>Prevalence and risk factors for epiretinal membrane: the Singapore Epidemiology of Eye Disease study</title><author>Cheung, Ning ; Tan, Shu-Pei ; Lee, Shu Yen ; Cheung, Gemmy Chui Ming ; Tan, Gavin ; Kumar, Neelam ; Cheng, Ching-Yu ; Wong, Tien Yin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-dbc53e870c71a1842af67e254439802b0352111d875935cc268d8f552287ff733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Asian Continental Ancestry Group - statistics & numerical data</topic><topic>Asian people</topic><topic>Blood pressure</topic><topic>Cataracts</topic><topic>Diabetes</topic><topic>Diabetic retinopathy</topic><topic>Epidemiology</topic><topic>Epiretinal Membrane - epidemiology</topic><topic>Eye diseases</topic><topic>Eye surgery</topic><topic>Family medical history</topic><topic>Female</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Macular degeneration</topic><topic>Male</topic><topic>Membranes</topic><topic>Middle Aged</topic><topic>Minority & ethnic groups</topic><topic>Ophthalmology</topic><topic>Population</topic><topic>Prevalence</topic><topic>Quality of life</topic><topic>Response rates</topic><topic>Risk Factors</topic><topic>Singapore - epidemiology</topic><topic>Socioeconomic factors</topic><topic>Veins & arteries</topic><topic>Visual impairment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheung, Ning</creatorcontrib><creatorcontrib>Tan, Shu-Pei</creatorcontrib><creatorcontrib>Lee, Shu Yen</creatorcontrib><creatorcontrib>Cheung, Gemmy Chui Ming</creatorcontrib><creatorcontrib>Tan, Gavin</creatorcontrib><creatorcontrib>Kumar, Neelam</creatorcontrib><creatorcontrib>Cheng, Ching-Yu</creatorcontrib><creatorcontrib>Wong, Tien Yin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheung, Ning</au><au>Tan, Shu-Pei</au><au>Lee, Shu Yen</au><au>Cheung, Gemmy Chui Ming</au><au>Tan, Gavin</au><au>Kumar, Neelam</au><au>Cheng, Ching-Yu</au><au>Wong, Tien Yin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and risk factors for epiretinal membrane: the Singapore Epidemiology of Eye Disease study</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>101</volume><issue>3</issue><spage>371</spage><pages>371-</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><abstract><![CDATA[To examine prevalence and risk factors of epiretinal membrane (ERM) in a large, contemporary, multiethnic Asian population.
Combined analysis of three population-based studies of eye diseases, with a total of 9799 Chinese, Malays and Indians residing in the general communities of Singapore. A comprehensive ophthalmic examination, interviews and laboratory blood tests were performed to assess potential risk factors. Digital retinal photographs were used to assess ERM according to a standardised protocol. ERM was classified into cellophane macular reflex (CMR) and/or preretinal macular fibrosis (PMF), and also as primary or secondary (in eyes with other retinal pathology or a history of cataract surgery).
The age-standardised and ethnicity-standardised prevalence was 12.1% for any ERM, 6.8% for CMR, 6.7% for PMF and 2.8% for bilateral ERM. ERM prevalence was higher in Chinese (13.0%) compared with Malays (7.9%) or Indians (8.7%). In multivariate analysis, significant factors associated with primary ERM were older age (OR 1.08 per year increase; p<0.01), Chinese ethnicity (OR 1.60 vs Indians; p<0.01; OR 1.39 vs Malays; p<0.01), smoking (OR 0.70; p=0.01), longer axial length (OR 1.07 per mm increase; p=0.03) and cataract (OR 0.64; p<0.01). Significant factors independently associated with secondary ERM were older age (OR 1.05; p<0.01), cataract surgery (OR 10.6; p<0.01) and diabetic retinopathy (OR 2.48; p<0.01).
ERM is common in Asians, particularly among Chinese. Older age is the most consistent risk factor for any ERM, and previous cataract surgery and diabetic retinopathy are the strongest risk factors for secondary ERM.]]></abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>27343209</pmid><doi>10.1136/bjophthalmol-2016-308563</doi></addata></record> |
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| subjects | Adult Age Age Distribution Aged Aged, 80 and over Asian Continental Ancestry Group - statistics & numerical data Asian people Blood pressure Cataracts Diabetes Diabetic retinopathy Epidemiology Epiretinal Membrane - epidemiology Eye diseases Eye surgery Family medical history Female Humans Laboratories Macular degeneration Male Membranes Middle Aged Minority & ethnic groups Ophthalmology Population Prevalence Quality of life Response rates Risk Factors Singapore - epidemiology Socioeconomic factors Veins & arteries Visual impairment |
| title | Prevalence and risk factors for epiretinal membrane: the Singapore Epidemiology of Eye Disease study |
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