Effects of the herbal extract PC-SPES on microtuble dynamics and paclitaxel-mediated prostate tumor growth inhibition
Background: PC-SPES is a botanical preparation shown to have efficacy in patients with androgen-dependent and androgen-independent prostate carcinoma. Several herbal constituents in PC-SPES inhibit tumor growth through cell cycle arrest and apoptosis, although the mechanisms of these activities are...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 2002-11, Vol.94 (21), p.1641 |
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| container_title | JNCI : Journal of the National Cancer Institute |
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| creator | Bonham, Michael J Galkin, Anna Montgomery, Bruce Stahl, William L |
| description | Background: PC-SPES is a botanical preparation shown to have efficacy in patients with androgen-dependent and androgen-independent prostate carcinoma. Several herbal constituents in PC-SPES inhibit tumor growth through cell cycle arrest and apoptosis, although the mechanisms of these activities are poorly defined. We sought to identify PC-SPES-induced changes in gene expression, specifically in those genes encoding cytoskeletal proteins that could be associated with PC-SPES-induced cytoxicity. |
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| ispartof | JNCI : Journal of the National Cancer Institute, 2002-11, Vol.94 (21), p.1641 |
| issn | 0027-8874 1460-2105 |
| language | eng |
| recordid | cdi_proquest_journals_221012652 |
| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Clinical trials Folk medicine Tumors |
| title | Effects of the herbal extract PC-SPES on microtuble dynamics and paclitaxel-mediated prostate tumor growth inhibition |
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