An update of knowledge on cortactin as a metastatic driver and potential therapeutic target in oral squamous cell carcinoma

Cortactin is a protein encoded by the CTTN gene, localized on chromosome band 11q13. As a result of the amplification of this band, an important event in oral carcinogenesis, CTTN is also usually amplified, promoting the frequent overexpression of cortactin. Cortactin enhances cell migration in oral...

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Veröffentlicht in:	Oral diseases 2019-05, Vol.25 (4), p.949-971
Hauptverfasser:	Ramos‐García, Pablo, González‐Moles, Miguel Ángel, González‐Ruiz, Lucía, Ayén, Ángela, Ruiz‐Ávila, Isabel, Navarro‐Triviño, Francisco José, Gil‐Montoya, José Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	11q13 Actin Angiogenesis Carcinogenesis Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell adhesion & migration Cell membranes Cell migration Cell proliferation Chromosomes, Human, Pair 11 cortactin Cortactin - genetics CTTN Exosomes Head & neck cancer Head and Neck Neoplasms Humans Lamellipodia Lymph nodes Lymph Nodes - pathology Metastases Mouth Neoplasms - genetics Mouth Neoplasms - pathology Neoplasm Invasiveness - genetics Neoplasm Metastasis Oral cancer Oral squamous cell carcinoma Phenotypes Pseudopodia Squamous cell carcinoma Therapeutic applications Tumor Microenvironment
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