Randomized Trial of Induction Chemotherapy With Cisplatin and 5-Fluorouracil With or Without Docetaxel for Larynx Preservation

Background Chemotherapy with cisplatin (P) and 5-fluorouracil (F) followed by radiotherapy in patients who respond to chemotherapy is an alternative to total laryngectomy for patients with locally advanced larynx and hypopharynx cancer. Data suggest that docetaxel (T) may add to the efficacy of PF....

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2009-04, Vol.101 (7), p.498-506
Hauptverfasser:	Pointreau, Yoann, Garaud, Pascal, Chapet, Sophie, Sire, Christian, Tuchais, Claude, Tortochaux, Jacques, Faivre, Sandrine, Guerrif, Stephane, Alfonsi, Marc, Calais, Gilles
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - surgery Chemotherapy Chemotherapy, Adjuvant - adverse effects Cisplatin - administration & dosage Clinical outcomes Clinical trials Female Fluorouracil - administration & dosage Humans Hypopharyngeal Neoplasms - drug therapy Hypopharyngeal Neoplasms - surgery Karnofsky Performance Status Laryngeal cancer Laryngeal Neoplasms - drug therapy Laryngeal Neoplasms - surgery Laryngectomy - methods Male Medical sciences Middle Aged Neoadjuvant Therapy - methods Oncology Pharmacology. Drug treatments Radiotherapy, Adjuvant - adverse effects Remission Induction Taxoids - administration & dosage Treatment Outcome Tumors Young Adult
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