Low incidence of nephrotoxicity following intravenous administration of iodinated contrast media: a prospective study
Objectives To estimate the incidence of contrast-induced acute kidney injury (CI-AKI) after intravenous (iv) iodinated contrast material (ICM) exposure. Methods This prospective cohort study included all consecutive patients who underwent radiological investigations using low-osmolar iopamidol 370 m...
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| Veröffentlicht in: | European radiology 2019-07, Vol.29 (7), p.3927-3934 |
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| creator | Castaldo, Pasqualina Frascà, Giovanni M. Brigante, Fabiana Ferrante, Luigi Magi, Simona Pavani, Marianna Skrami, Edlira Giuseppetti, Gian Marco Polonara, Gabriele Amoroso, Salvatore |
| description | Objectives
To estimate the incidence of contrast-induced acute kidney injury (CI-AKI) after intravenous (iv) iodinated contrast material (ICM) exposure.
Methods
This prospective cohort study included all consecutive patients who underwent radiological investigations using low-osmolar iopamidol 370 mg/ml in a regional hospital over a period of 36 months, without any exclusion criteria. The estimated glomerular filtration rate (eGFR) was evaluated using the MRDR equation before (2–10 days) and after (24–36 h) radiological investigations. CI-AKI was defined as a ≥ 25% decrease in eGFR from baseline. CI-AKI incidence was estimated using a binomial distribution. The association between CI-AKI and demographic and clinical characteristics was modeled using logistic regression.
Results
The study included 1541 patients with a median age of 68 (1st–3rd quartiles 58–76) years with various comorbidities, 30% of whom had pre-existing CKD. Patients affected by stage III or IV chronic kidney disease (CKD) received an infusion of 0.9% normal saline (1.0–1.5 ml/kg/h) before and after iso-osmolar iodixanol administration. CI-AKI was observed in 33 patients (2.1%, 95% CI 1.5–3.0). The logistic regression analysis showed that antibiotic and statin therapies were significantly associated with CI-AKI. The probability of developing CI-AKI decreased by 80% in patients taking statins (OR = 0.20, 95% CI 0.03; 0.68) and increased approximately three times in patients with antibiotic therapy compared with those who did not take statins and antibiotics (OR = 2.92, 95% CI 1.21; 6.36).
Conclusions
Our data suggest that low-osmolar iopamidol carries a low incidence of nephrotoxicity, even in subjects with various comorbid conditions or reduced renal function.
Key Points
• IV administration of ICM carries a low incidence of nephrotoxicity, which was transient in observed patients.
• Statin therapy is negatively associated with AKI in patients exposed to ICM.
• Pre-existing impairment of renal function is not associated with AKI in patients exposed to ICM. |
| doi_str_mv | 10.1007/s00330-019-06147-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2209788480</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2209788480</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-1d942e060dc45fc1fba237faa7a17bd41095af0e4d3e100fc3405b083ed1d8543</originalsourceid><addsrcrecordid>eNp9kE1PAyEURYnR2Fr9Ay4MievRx8B0BnfG-JU0caNrwvBRaVqoA9Pafy-1VXeuSODc-x4HoXMCVwSgvo4AlEIBhBcwJqwuygM0JIyWBYGGHaIhcNoUNedsgE5inAEAz9gxGlDgDaeMD1E_CWvsvHLaeGVwsNib5XsXUvh0yqUNtmE-D2vnp5lKnVwZH_qIpV4472K-SC74bcwF7bxMRmMVtmBMeGG0kzdY4mUX4tKo5FYGx9TrzSk6snIezdn-HKG3h_vXu6di8vL4fHc7KRStq1QQzVlpYAxascoqYltZ0tpKWUtSt5oR4JW0YJimJhuxijKoWmio0UQ3FaMjdLnrzRt89CYmMQt95_NIUZbA66ZhDWSq3FEq7xk7Y8WycwvZbQQBsTUtdqZFNi2-TYsyhy721X2bP_ob-VGbAboDYn7yU9P9zf6n9gtQb4wi</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2209788480</pqid></control><display><type>article</type><title>Low incidence of nephrotoxicity following intravenous administration of iodinated contrast media: a prospective study</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Castaldo, Pasqualina ; Frascà, Giovanni M. ; Brigante, Fabiana ; Ferrante, Luigi ; Magi, Simona ; Pavani, Marianna ; Skrami, Edlira ; Giuseppetti, Gian Marco ; Polonara, Gabriele ; Amoroso, Salvatore</creator><creatorcontrib>Castaldo, Pasqualina ; Frascà, Giovanni M. ; Brigante, Fabiana ; Ferrante, Luigi ; Magi, Simona ; Pavani, Marianna ; Skrami, Edlira ; Giuseppetti, Gian Marco ; Polonara, Gabriele ; Amoroso, Salvatore</creatorcontrib><description>Objectives
To estimate the incidence of contrast-induced acute kidney injury (CI-AKI) after intravenous (iv) iodinated contrast material (ICM) exposure.
Methods
This prospective cohort study included all consecutive patients who underwent radiological investigations using low-osmolar iopamidol 370 mg/ml in a regional hospital over a period of 36 months, without any exclusion criteria. The estimated glomerular filtration rate (eGFR) was evaluated using the MRDR equation before (2–10 days) and after (24–36 h) radiological investigations. CI-AKI was defined as a ≥ 25% decrease in eGFR from baseline. CI-AKI incidence was estimated using a binomial distribution. The association between CI-AKI and demographic and clinical characteristics was modeled using logistic regression.
Results
The study included 1541 patients with a median age of 68 (1st–3rd quartiles 58–76) years with various comorbidities, 30% of whom had pre-existing CKD. Patients affected by stage III or IV chronic kidney disease (CKD) received an infusion of 0.9% normal saline (1.0–1.5 ml/kg/h) before and after iso-osmolar iodixanol administration. CI-AKI was observed in 33 patients (2.1%, 95% CI 1.5–3.0). The logistic regression analysis showed that antibiotic and statin therapies were significantly associated with CI-AKI. The probability of developing CI-AKI decreased by 80% in patients taking statins (OR = 0.20, 95% CI 0.03; 0.68) and increased approximately three times in patients with antibiotic therapy compared with those who did not take statins and antibiotics (OR = 2.92, 95% CI 1.21; 6.36).
Conclusions
Our data suggest that low-osmolar iopamidol carries a low incidence of nephrotoxicity, even in subjects with various comorbid conditions or reduced renal function.
Key Points
• IV administration of ICM carries a low incidence of nephrotoxicity, which was transient in observed patients.
• Statin therapy is negatively associated with AKI in patients exposed to ICM.
• Pre-existing impairment of renal function is not associated with AKI in patients exposed to ICM.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-019-06147-2</identifier><identifier>PMID: 30989349</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acute Kidney Injury - chemically induced ; Acute Kidney Injury - epidemiology ; Administration, Intravenous ; Aged ; Antibiotics ; Binomial distribution ; Contrast Media ; Contrast Media - administration & dosage ; Demographics ; Diagnostic Radiology ; Epidermal growth factor receptors ; Exposure ; Female ; Glomerular Filtration Rate ; Health risk assessment ; Humans ; Imaging ; Incidence ; Internal Medicine ; Interventional Radiology ; Intravenous administration ; Iopamidol - administration & dosage ; Iopamidol - adverse effects ; Kidney diseases ; Kidneys ; Logistic Models ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neuroradiology ; Odds Ratio ; Patients ; Prospective Studies ; Quartiles ; Radiology ; Regression analysis ; Renal function ; Statins ; Statistical analysis ; Therapy ; Triiodobenzoic Acids - administration & dosage ; Triiodobenzoic Acids - adverse effects ; Ultrasound</subject><ispartof>European radiology, 2019-07, Vol.29 (7), p.3927-3934</ispartof><rights>European Society of Radiology 2019</rights><rights>European Radiology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-1d942e060dc45fc1fba237faa7a17bd41095af0e4d3e100fc3405b083ed1d8543</citedby><cites>FETCH-LOGICAL-c375t-1d942e060dc45fc1fba237faa7a17bd41095af0e4d3e100fc3405b083ed1d8543</cites><orcidid>0000-0003-0530-2262</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-019-06147-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-019-06147-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30989349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castaldo, Pasqualina</creatorcontrib><creatorcontrib>Frascà, Giovanni M.</creatorcontrib><creatorcontrib>Brigante, Fabiana</creatorcontrib><creatorcontrib>Ferrante, Luigi</creatorcontrib><creatorcontrib>Magi, Simona</creatorcontrib><creatorcontrib>Pavani, Marianna</creatorcontrib><creatorcontrib>Skrami, Edlira</creatorcontrib><creatorcontrib>Giuseppetti, Gian Marco</creatorcontrib><creatorcontrib>Polonara, Gabriele</creatorcontrib><creatorcontrib>Amoroso, Salvatore</creatorcontrib><title>Low incidence of nephrotoxicity following intravenous administration of iodinated contrast media: a prospective study</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
To estimate the incidence of contrast-induced acute kidney injury (CI-AKI) after intravenous (iv) iodinated contrast material (ICM) exposure.
Methods
This prospective cohort study included all consecutive patients who underwent radiological investigations using low-osmolar iopamidol 370 mg/ml in a regional hospital over a period of 36 months, without any exclusion criteria. The estimated glomerular filtration rate (eGFR) was evaluated using the MRDR equation before (2–10 days) and after (24–36 h) radiological investigations. CI-AKI was defined as a ≥ 25% decrease in eGFR from baseline. CI-AKI incidence was estimated using a binomial distribution. The association between CI-AKI and demographic and clinical characteristics was modeled using logistic regression.
Results
The study included 1541 patients with a median age of 68 (1st–3rd quartiles 58–76) years with various comorbidities, 30% of whom had pre-existing CKD. Patients affected by stage III or IV chronic kidney disease (CKD) received an infusion of 0.9% normal saline (1.0–1.5 ml/kg/h) before and after iso-osmolar iodixanol administration. CI-AKI was observed in 33 patients (2.1%, 95% CI 1.5–3.0). The logistic regression analysis showed that antibiotic and statin therapies were significantly associated with CI-AKI. The probability of developing CI-AKI decreased by 80% in patients taking statins (OR = 0.20, 95% CI 0.03; 0.68) and increased approximately three times in patients with antibiotic therapy compared with those who did not take statins and antibiotics (OR = 2.92, 95% CI 1.21; 6.36).
Conclusions
Our data suggest that low-osmolar iopamidol carries a low incidence of nephrotoxicity, even in subjects with various comorbid conditions or reduced renal function.
Key Points
• IV administration of ICM carries a low incidence of nephrotoxicity, which was transient in observed patients.
• Statin therapy is negatively associated with AKI in patients exposed to ICM.
• Pre-existing impairment of renal function is not associated with AKI in patients exposed to ICM.</description><subject>Acute Kidney Injury - chemically induced</subject><subject>Acute Kidney Injury - epidemiology</subject><subject>Administration, Intravenous</subject><subject>Aged</subject><subject>Antibiotics</subject><subject>Binomial distribution</subject><subject>Contrast Media</subject><subject>Contrast Media - administration & dosage</subject><subject>Demographics</subject><subject>Diagnostic Radiology</subject><subject>Epidermal growth factor receptors</subject><subject>Exposure</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Imaging</subject><subject>Incidence</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Intravenous administration</subject><subject>Iopamidol - administration & dosage</subject><subject>Iopamidol - adverse effects</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neuroradiology</subject><subject>Odds Ratio</subject><subject>Patients</subject><subject>Prospective Studies</subject><subject>Quartiles</subject><subject>Radiology</subject><subject>Regression analysis</subject><subject>Renal function</subject><subject>Statins</subject><subject>Statistical analysis</subject><subject>Therapy</subject><subject>Triiodobenzoic Acids - administration & dosage</subject><subject>Triiodobenzoic Acids - adverse effects</subject><subject>Ultrasound</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kE1PAyEURYnR2Fr9Ay4MievRx8B0BnfG-JU0caNrwvBRaVqoA9Pafy-1VXeuSODc-x4HoXMCVwSgvo4AlEIBhBcwJqwuygM0JIyWBYGGHaIhcNoUNedsgE5inAEAz9gxGlDgDaeMD1E_CWvsvHLaeGVwsNib5XsXUvh0yqUNtmE-D2vnp5lKnVwZH_qIpV4472K-SC74bcwF7bxMRmMVtmBMeGG0kzdY4mUX4tKo5FYGx9TrzSk6snIezdn-HKG3h_vXu6di8vL4fHc7KRStq1QQzVlpYAxascoqYltZ0tpKWUtSt5oR4JW0YJimJhuxijKoWmio0UQ3FaMjdLnrzRt89CYmMQt95_NIUZbA66ZhDWSq3FEq7xk7Y8WycwvZbQQBsTUtdqZFNi2-TYsyhy721X2bP_ob-VGbAboDYn7yU9P9zf6n9gtQb4wi</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Castaldo, Pasqualina</creator><creator>Frascà, Giovanni M.</creator><creator>Brigante, Fabiana</creator><creator>Ferrante, Luigi</creator><creator>Magi, Simona</creator><creator>Pavani, Marianna</creator><creator>Skrami, Edlira</creator><creator>Giuseppetti, Gian Marco</creator><creator>Polonara, Gabriele</creator><creator>Amoroso, Salvatore</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0003-0530-2262</orcidid></search><sort><creationdate>20190701</creationdate><title>Low incidence of nephrotoxicity following intravenous administration of iodinated contrast media: a prospective study</title><author>Castaldo, Pasqualina ; Frascà, Giovanni M. ; Brigante, Fabiana ; Ferrante, Luigi ; Magi, Simona ; Pavani, Marianna ; Skrami, Edlira ; Giuseppetti, Gian Marco ; Polonara, Gabriele ; Amoroso, Salvatore</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-1d942e060dc45fc1fba237faa7a17bd41095af0e4d3e100fc3405b083ed1d8543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acute Kidney Injury - chemically induced</topic><topic>Acute Kidney Injury - epidemiology</topic><topic>Administration, Intravenous</topic><topic>Aged</topic><topic>Antibiotics</topic><topic>Binomial distribution</topic><topic>Contrast Media</topic><topic>Contrast Media - administration & dosage</topic><topic>Demographics</topic><topic>Diagnostic Radiology</topic><topic>Epidermal growth factor receptors</topic><topic>Exposure</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Imaging</topic><topic>Incidence</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Intravenous administration</topic><topic>Iopamidol - administration & dosage</topic><topic>Iopamidol - adverse effects</topic><topic>Kidney diseases</topic><topic>Kidneys</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neuroradiology</topic><topic>Odds Ratio</topic><topic>Patients</topic><topic>Prospective Studies</topic><topic>Quartiles</topic><topic>Radiology</topic><topic>Regression analysis</topic><topic>Renal function</topic><topic>Statins</topic><topic>Statistical analysis</topic><topic>Therapy</topic><topic>Triiodobenzoic Acids - administration & dosage</topic><topic>Triiodobenzoic Acids - adverse effects</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Castaldo, Pasqualina</creatorcontrib><creatorcontrib>Frascà, Giovanni M.</creatorcontrib><creatorcontrib>Brigante, Fabiana</creatorcontrib><creatorcontrib>Ferrante, Luigi</creatorcontrib><creatorcontrib>Magi, Simona</creatorcontrib><creatorcontrib>Pavani, Marianna</creatorcontrib><creatorcontrib>Skrami, Edlira</creatorcontrib><creatorcontrib>Giuseppetti, Gian Marco</creatorcontrib><creatorcontrib>Polonara, Gabriele</creatorcontrib><creatorcontrib>Amoroso, Salvatore</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castaldo, Pasqualina</au><au>Frascà, Giovanni M.</au><au>Brigante, Fabiana</au><au>Ferrante, Luigi</au><au>Magi, Simona</au><au>Pavani, Marianna</au><au>Skrami, Edlira</au><au>Giuseppetti, Gian Marco</au><au>Polonara, Gabriele</au><au>Amoroso, Salvatore</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low incidence of nephrotoxicity following intravenous administration of iodinated contrast media: a prospective study</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>29</volume><issue>7</issue><spage>3927</spage><epage>3934</epage><pages>3927-3934</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
To estimate the incidence of contrast-induced acute kidney injury (CI-AKI) after intravenous (iv) iodinated contrast material (ICM) exposure.
Methods
This prospective cohort study included all consecutive patients who underwent radiological investigations using low-osmolar iopamidol 370 mg/ml in a regional hospital over a period of 36 months, without any exclusion criteria. The estimated glomerular filtration rate (eGFR) was evaluated using the MRDR equation before (2–10 days) and after (24–36 h) radiological investigations. CI-AKI was defined as a ≥ 25% decrease in eGFR from baseline. CI-AKI incidence was estimated using a binomial distribution. The association between CI-AKI and demographic and clinical characteristics was modeled using logistic regression.
Results
The study included 1541 patients with a median age of 68 (1st–3rd quartiles 58–76) years with various comorbidities, 30% of whom had pre-existing CKD. Patients affected by stage III or IV chronic kidney disease (CKD) received an infusion of 0.9% normal saline (1.0–1.5 ml/kg/h) before and after iso-osmolar iodixanol administration. CI-AKI was observed in 33 patients (2.1%, 95% CI 1.5–3.0). The logistic regression analysis showed that antibiotic and statin therapies were significantly associated with CI-AKI. The probability of developing CI-AKI decreased by 80% in patients taking statins (OR = 0.20, 95% CI 0.03; 0.68) and increased approximately three times in patients with antibiotic therapy compared with those who did not take statins and antibiotics (OR = 2.92, 95% CI 1.21; 6.36).
Conclusions
Our data suggest that low-osmolar iopamidol carries a low incidence of nephrotoxicity, even in subjects with various comorbid conditions or reduced renal function.
Key Points
• IV administration of ICM carries a low incidence of nephrotoxicity, which was transient in observed patients.
• Statin therapy is negatively associated with AKI in patients exposed to ICM.
• Pre-existing impairment of renal function is not associated with AKI in patients exposed to ICM.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30989349</pmid><doi>10.1007/s00330-019-06147-2</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0530-2262</orcidid></addata></record> |
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| ispartof | European radiology, 2019-07, Vol.29 (7), p.3927-3934 |
| issn | 0938-7994 1432-1084 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Acute Kidney Injury - chemically induced Acute Kidney Injury - epidemiology Administration, Intravenous Aged Antibiotics Binomial distribution Contrast Media Contrast Media - administration & dosage Demographics Diagnostic Radiology Epidermal growth factor receptors Exposure Female Glomerular Filtration Rate Health risk assessment Humans Imaging Incidence Internal Medicine Interventional Radiology Intravenous administration Iopamidol - administration & dosage Iopamidol - adverse effects Kidney diseases Kidneys Logistic Models Male Medicine Medicine & Public Health Middle Aged Neuroradiology Odds Ratio Patients Prospective Studies Quartiles Radiology Regression analysis Renal function Statins Statistical analysis Therapy Triiodobenzoic Acids - administration & dosage Triiodobenzoic Acids - adverse effects Ultrasound |
| title | Low incidence of nephrotoxicity following intravenous administration of iodinated contrast media: a prospective study |
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