IMPAIRED CARDIOVASCULAR RESPONSIVENESS IN LIVER DISEASE

Cardiovascular responsiveness to reflex autonomic stimulation was significantly impaired in patients with cirrhosis compared with control subjects. Peripheral vascular responses to exogenous noradrenaline were also impaired in cirrhotic patients, but peripheral vascular responses to infused adrenali...

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Veröffentlicht in:The Lancet (British edition) 1975-08, Vol.306 (7931), p.382-385
Hauptverfasser: Lunzer, MichaelR, Newman, StephenP, Bernard, AlbertG, Manghani, KishuK, Sherlock, SheilaP.V., Ginsburg, Jean
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container_end_page 385
container_issue 7931
container_start_page 382
container_title The Lancet (British edition)
container_volume 306
creator Lunzer, MichaelR
Newman, StephenP
Bernard, AlbertG
Manghani, KishuK
Sherlock, SheilaP.V.
Ginsburg, Jean
description Cardiovascular responsiveness to reflex autonomic stimulation was significantly impaired in patients with cirrhosis compared with control subjects. Peripheral vascular responses to exogenous noradrenaline were also impaired in cirrhotic patients, but peripheral vascular responses to infused adrenaline and to angiotensin II were similar in both groups. Impaired cardiovascular reactivity in patients with chronic liver disease could preidspose them to circulatory failure after hæmorrhage or surgery and should be considered when prescribing drugd which affect autonomic activity.
doi_str_mv 10.1016/S0140-6736(75)92896-2
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subjects Angiotensin
Angiotensin II
Cirrhosis
Epinephrine
Liver
Liver cirrhosis
Liver diseases
Noradrenaline
Norepinephrine
Patients
Surgery
title IMPAIRED CARDIOVASCULAR RESPONSIVENESS IN LIVER DISEASE
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