Determination of glutathione S-transferase [mu] and [Theta] polymorphisms in neurological disease
1. Correlations between deletions in two glutathione S-transferase (GST) genes, GSTM1 and GSTT1 and susceptibility to Alzheimer's disease (AD), motor neuron disease (MND) and Parkinson's disease (PD) have been investigated by PCR, using primers specific for both genes. 2. It was found that...
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| Veröffentlicht in: | Human & experimental toxicology 1999-03, Vol.18 (3), p.141 |
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| creator | M.C.M.J. Stroombergen Waring, R H |
| description | 1. Correlations between deletions in two glutathione S-transferase (GST) genes, GSTM1 and GSTT1 and susceptibility to Alzheimer's disease (AD), motor neuron disease (MND) and Parkinson's disease (PD) have been investigated by PCR, using primers specific for both genes. 2. It was found that males with a deletion of the GSTM1 gene were more susceptible to PD and males with a deletion of the GSTT1 gene more susceptible to MND and PD, possibly implying that environmental factors which specifically target men may be involved. Furthermore, subjects with a deletion of the GSTT1 gene were more susceptible to AD. |
| doi_str_mv | 10.1191/096032799678839815 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0960-3271 |
| ispartof | Human & experimental toxicology, 1999-03, Vol.18 (3), p.141 |
| issn | 0960-3271 1477-0903 |
| language | eng |
| recordid | cdi_proquest_journals_220862653 |
| source | Sage Journals GOLD Open Access 2024; Alma/SFX Local Collection |
| subjects | Alzheimer's disease Enzymes Genes Minority & ethnic groups Motor neurone disease Parkinson's disease |
| title | Determination of glutathione S-transferase [mu] and [Theta] polymorphisms in neurological disease |
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