Dose-Dependent Sustained Release of Dexamethasone in Inner Ear Cochlear Fluids Using a Novel Local Delivery Approach

The thermo-reversible triblock copolymer poloxamer 407 was investigated as a drug delivery vehicle for micronized dexamethasone into the middle and inner ears of guinea pigs. The study characterized the gelation and in vitro release kinetics of poloxamer formulations. In vivo, the pharmacokinetic pr...

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Veröffentlicht in:	Audiology & neurotology 2009-01, Vol.14 (6), p.393-401
Hauptverfasser:	Wang, Xiaobo, Dellamary, Luis, Fernandez, Rayne, Harrop, Anne, Keithley, Elizabeth M., Harris, Jeffrey P., Ye, Qiang, Lichter, Jay, LeBel, Carl, Piu, Fabrice
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Clinical outcomes Cochlea - drug effects Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - pharmacokinetics Delivery. Postpartum. Lactation Dexamethasone - administration & dosage Dexamethasone - pharmacokinetics Dose-Response Relationship, Drug Drug Administration Routes Drug Carriers - administration & dosage Drug Carriers - pharmacokinetics Drug delivery systems Drug therapy Ear diseases Electrophysiology Evoked Potentials, Auditory, Brain Stem - physiology Female Guinea Pigs Gynecology. Andrology. Obstetrics Hearing - drug effects Hearing Tests Medical sciences Otorhinolaryngology. Stomatology Perilymph - drug effects Pharmacology Pharmacology. Drug treatments Poloxamer - administration & dosage Poloxamer - pharmacokinetics Rodents Tympanic Membrane - drug effects
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