Oral aluminum administration to rats with normal renal function. 2. Body distribution
Aluminum (Al) has no known physiological function and is not considered an essential dietary compound. Nowadays, it is recognized as an element that can produce adverse effects on biological systems. The present study determined Al partitioning in the body compartments of rats that have been orally...
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| Veröffentlicht in: | Human & experimental toxicology 1998-06, Vol.17 (6), p.318-322 |
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| creator | Garbossa, G. Gálvez, G. Pérez, G. Stripeikis, J. Tudino, M. Nesse, A. |
| description | Aluminum (Al) has no known physiological function and is not considered an essential dietary compound. Nowadays, it is recognized as an element that can produce adverse effects on biological systems. The present study determined Al partitioning in the body compartments of rats that have been orally exposed for 15 weeks. Three experimental groups were studied: Controls (C, n=19), TAl-1 (n=10) rats receiving daily doses of Al citrate (1.0 micromol/g body weight) by gavage and TAl-2 (n=13), receiving Al citrate with the drinking water (100 mmol/ l). At the end of the experimental period, the Al contents of organs and sera were determined. Results are expressed as median and range values. Comparing the TAl-2 rats with the control ones, remarkable Al accumulation could be observed in serum (4.8/2.7-16.3 vs 0.4/0.2-1.2 micromol/l, P |
| doi_str_mv | 10.1191/096032798678908828 |
| format | Article |
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Body distribution</title><source>SAGE Complete A-Z List</source><source>Alma/SFX Local Collection</source><creator>Garbossa, G. ; Gálvez, G. ; Pérez, G. ; Stripeikis, J. ; Tudino, M. ; Nesse, A.</creator><creatorcontrib>Garbossa, G. ; Gálvez, G. ; Pérez, G. ; Stripeikis, J. ; Tudino, M. ; Nesse, A.</creatorcontrib><description><![CDATA[Aluminum (Al) has no known physiological function and is not considered an essential dietary compound. Nowadays, it is recognized as an element that can produce adverse effects on biological systems. The present study determined Al partitioning in the body compartments of rats that have been orally exposed for 15 weeks. Three experimental groups were studied: Controls (C, n=19), TAl-1 (n=10) rats receiving daily doses of Al citrate (1.0 micromol/g body weight) by gavage and TAl-2 (n=13), receiving Al citrate with the drinking water (100 mmol/ l). At the end of the experimental period, the Al contents of organs and sera were determined. Results are expressed as median and range values. Comparing the TAl-2 rats with the control ones, remarkable Al accumulation could be observed in serum (4.8/2.7-16.3 vs 0.4/0.2-1.2 micromol/l, P<0.001), bone (3.33/1.78-4.85 vs 1.00/0.48-1.59 micromol/ g, P<0.001), kidney (2.33/0.96-3.15 vs 0.52/0.22-2.07 micromol/g, P<0.001), spleen (2.22/0.70-4.19 vs 0.27/ 0.11 - 0.36 micromol/g, P< 0.001) and liver (0.60/0.42-0.91 vs 0.24/0.14-0.78 micromol/g, P<0.01) while brain Al content was not significantly increased. Aluminum levels were raised in the TAl-1 group only in serum (2.8/1.3 - 10.4 micromol/ g, P < 0.001), bone (1.85/1.00-3.41 micromol/g, P < 0.001) and kidney (1.74/0.96-2.07 micromol/g, P<0.01). Bone Al concentration increased in a dose-dependent manner (TAl-2 vs TAl-1, P<0.001). The results demonstrate different tissue Al accumulation in rats chronically exposed to Al citrate, irrespective of their intact renal function.]]></description><identifier>ISSN: 0960-3271</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1191/096032798678908828</identifier><language>eng</language><publisher>London: Sage Publications Ltd</publisher><ispartof>Human & experimental toxicology, 1998-06, Vol.17 (6), p.318-322</ispartof><rights>1998 Arnold</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-3b64284f309225afdf50691fb88e0db23a519cd32069f641cce8b634b847ac93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids></links><search><creatorcontrib>Garbossa, G.</creatorcontrib><creatorcontrib>Gálvez, G.</creatorcontrib><creatorcontrib>Pérez, G.</creatorcontrib><creatorcontrib>Stripeikis, J.</creatorcontrib><creatorcontrib>Tudino, M.</creatorcontrib><creatorcontrib>Nesse, A.</creatorcontrib><title>Oral aluminum administration to rats with normal renal function. 2. Body distribution</title><title>Human & experimental toxicology</title><description><![CDATA[Aluminum (Al) has no known physiological function and is not considered an essential dietary compound. Nowadays, it is recognized as an element that can produce adverse effects on biological systems. The present study determined Al partitioning in the body compartments of rats that have been orally exposed for 15 weeks. Three experimental groups were studied: Controls (C, n=19), TAl-1 (n=10) rats receiving daily doses of Al citrate (1.0 micromol/g body weight) by gavage and TAl-2 (n=13), receiving Al citrate with the drinking water (100 mmol/ l). At the end of the experimental period, the Al contents of organs and sera were determined. Results are expressed as median and range values. Comparing the TAl-2 rats with the control ones, remarkable Al accumulation could be observed in serum (4.8/2.7-16.3 vs 0.4/0.2-1.2 micromol/l, P<0.001), bone (3.33/1.78-4.85 vs 1.00/0.48-1.59 micromol/ g, P<0.001), kidney (2.33/0.96-3.15 vs 0.52/0.22-2.07 micromol/g, P<0.001), spleen (2.22/0.70-4.19 vs 0.27/ 0.11 - 0.36 micromol/g, P< 0.001) and liver (0.60/0.42-0.91 vs 0.24/0.14-0.78 micromol/g, P<0.01) while brain Al content was not significantly increased. Aluminum levels were raised in the TAl-1 group only in serum (2.8/1.3 - 10.4 micromol/ g, P < 0.001), bone (1.85/1.00-3.41 micromol/g, P < 0.001) and kidney (1.74/0.96-2.07 micromol/g, P<0.01). Bone Al concentration increased in a dose-dependent manner (TAl-2 vs TAl-1, P<0.001). The results demonstrate different tissue Al accumulation in rats chronically exposed to Al citrate, irrespective of their intact renal function.]]></description><issn>0960-3271</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNplkE9LxDAQxYMoWFe_gKfgvetk0qbJURf_wcJe1nNJ0wa7tM2aNMh-e1PWm5d5w-M3w-MRcs9gzZhij6AEcKyUFJVUICXKC5KxoqpyUMAvSbYAeSLYNbkJ4QAAQpUsI587rweqhzj2UxypbpP2YfZ67t1EZ0fTFuhPP3_Ryfkxsb6b0rRxMguyprimz6490XY565u4uLfkyuohdHd_uiL715f95j3f7t4-Nk_b3GCFc84bUaAsLAeFWGrb2jLFYraRsoO2Qa5LpkzLMblWFMyYTjaCF40sKm0UX5GH89ujd9-xC3N9cNGneKFGBClYWUKC8AwZ70Lwna2Pvh-1P9UM6qW8-n95_Bcgs2F-</recordid><startdate>19980601</startdate><enddate>19980601</enddate><creator>Garbossa, G.</creator><creator>Gálvez, G.</creator><creator>Pérez, G.</creator><creator>Stripeikis, J.</creator><creator>Tudino, M.</creator><creator>Nesse, A.</creator><general>Sage Publications Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>SOI</scope></search><sort><creationdate>19980601</creationdate><title>Oral aluminum administration to rats with normal renal function. 2. Body distribution</title><author>Garbossa, G. ; Gálvez, G. ; Pérez, G. ; Stripeikis, J. ; Tudino, M. ; Nesse, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-3b64284f309225afdf50691fb88e0db23a519cd32069f641cce8b634b847ac93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garbossa, G.</creatorcontrib><creatorcontrib>Gálvez, G.</creatorcontrib><creatorcontrib>Pérez, G.</creatorcontrib><creatorcontrib>Stripeikis, J.</creatorcontrib><creatorcontrib>Tudino, M.</creatorcontrib><creatorcontrib>Nesse, A.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environment Abstracts</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garbossa, G.</au><au>Gálvez, G.</au><au>Pérez, G.</au><au>Stripeikis, J.</au><au>Tudino, M.</au><au>Nesse, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral aluminum administration to rats with normal renal function. 2. Body distribution</atitle><jtitle>Human & experimental toxicology</jtitle><date>1998-06-01</date><risdate>1998</risdate><volume>17</volume><issue>6</issue><spage>318</spage><epage>322</epage><pages>318-322</pages><issn>0960-3271</issn><eissn>1477-0903</eissn><abstract><![CDATA[Aluminum (Al) has no known physiological function and is not considered an essential dietary compound. Nowadays, it is recognized as an element that can produce adverse effects on biological systems. The present study determined Al partitioning in the body compartments of rats that have been orally exposed for 15 weeks. Three experimental groups were studied: Controls (C, n=19), TAl-1 (n=10) rats receiving daily doses of Al citrate (1.0 micromol/g body weight) by gavage and TAl-2 (n=13), receiving Al citrate with the drinking water (100 mmol/ l). At the end of the experimental period, the Al contents of organs and sera were determined. Results are expressed as median and range values. Comparing the TAl-2 rats with the control ones, remarkable Al accumulation could be observed in serum (4.8/2.7-16.3 vs 0.4/0.2-1.2 micromol/l, P<0.001), bone (3.33/1.78-4.85 vs 1.00/0.48-1.59 micromol/ g, P<0.001), kidney (2.33/0.96-3.15 vs 0.52/0.22-2.07 micromol/g, P<0.001), spleen (2.22/0.70-4.19 vs 0.27/ 0.11 - 0.36 micromol/g, P< 0.001) and liver (0.60/0.42-0.91 vs 0.24/0.14-0.78 micromol/g, P<0.01) while brain Al content was not significantly increased. Aluminum levels were raised in the TAl-1 group only in serum (2.8/1.3 - 10.4 micromol/ g, P < 0.001), bone (1.85/1.00-3.41 micromol/g, P < 0.001) and kidney (1.74/0.96-2.07 micromol/g, P<0.01). Bone Al concentration increased in a dose-dependent manner (TAl-2 vs TAl-1, P<0.001). The results demonstrate different tissue Al accumulation in rats chronically exposed to Al citrate, irrespective of their intact renal function.]]></abstract><cop>London</cop><pub>Sage Publications Ltd</pub><doi>10.1191/096032798678908828</doi><tpages>5</tpages></addata></record> |
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| title | Oral aluminum administration to rats with normal renal function. 2. Body distribution |
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