Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas

Tumour cells are known to be highly glycolytic, thus producing high amounts of lactic acid. Monocarboxylate transporters (MCTs), by promoting the efflux of the accumulating acids, constitute one of the most important mechanisms in the maintenance of tumour intracellular pH. Since data concerning MCT...

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Veröffentlicht in:	Virchows Archiv : an international journal of pathology 2008-02, Vol.452 (2), p.139-146
Hauptverfasser:	Pinheiro, Céline, Longatto, Adhemar, Scapulatempo, Cristovam, Ferreira, Luísa, Martins, Sandra, Pellerin, Luc, Rodrigues, Mesquita, Alves, Venâncio A. F., Schmitt, Fernando, Baltazar, Fátima
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Mucinous - chemistry Adenocarcinoma, Mucinous - metabolism Adenocarcinoma, Mucinous - secondary Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - metabolism Carcinogenesis Cell Membrane - metabolism Child, Preschool Ciências Médicas Colorectal carcinoma Colorectal Neoplasms - chemistry Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Medicina Básica Medicine Medicine & Public Health Middle Aged Monocarboxylate transporter Monocarboxylic Acid Transporters - metabolism Muscle Proteins - metabolism Neoplasm Invasiveness Neoplasm Staging Original Article Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Protein Isoforms Science & Technology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Symporters - metabolism Tumors
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