Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas
Tumour cells are known to be highly glycolytic, thus producing high amounts of lactic acid. Monocarboxylate transporters (MCTs), by promoting the efflux of the accumulating acids, constitute one of the most important mechanisms in the maintenance of tumour intracellular pH. Since data concerning MCT...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2008-02, Vol.452 (2), p.139-146 |
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| creator | Pinheiro, Céline Longatto, Adhemar Scapulatempo, Cristovam Ferreira, Luísa Martins, Sandra Pellerin, Luc Rodrigues, Mesquita Alves, Venâncio A. F. Schmitt, Fernando Baltazar, Fátima |
| description | Tumour cells are known to be highly glycolytic, thus producing high amounts of lactic acid. Monocarboxylate transporters (MCTs), by promoting the efflux of the accumulating acids, constitute one of the most important mechanisms in the maintenance of tumour intracellular pH. Since data concerning MCT expression in colorectal carcinomas (CRC) are scarce and controversial, the present study aimed to assess the expressions of MCT1, 2, and 4 in a well characterized series of CRC and assess their role in CRC carcinogenesis. CRC samples (126 cases) were analyzed for MCT1, MCT2, and MCT4 immunoexpression and findings correlated with clinico-pathological parameters. Expression of all MCT isoforms in tumour cells was significantly increased when compared to adjacent normal epithelium. Remarkably, there was a significant gain of membrane expression for MCT1 and MCT4 and loss of plasma membrane expression for MCT2 in tumour cells. Plasma membrane expression of MCT1 was directly related to the presence of vascular invasion. This is the larger study on MCT expression in CRC and evaluates for the first time its clinico-pathological significance. The increased expression of these transporters suggests an important role in CRC, which might justify their use, especially MCT1 and MCT4, as targets in CRC drug therapy
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| doi_str_mv | 10.1007/s00428-007-0558-5 |
| format | Article |
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Fundação para a Ciência e Tecnologia (SFRH/BD/27465/2006)</description><subject>Adenocarcinoma, Mucinous - chemistry</subject><subject>Adenocarcinoma, Mucinous - metabolism</subject><subject>Adenocarcinoma, Mucinous - secondary</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinogenesis</subject><subject>Cell Membrane - metabolism</subject><subject>Child, Preschool</subject><subject>Ciências Médicas</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - chemistry</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicina Básica</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Monocarboxylate transporter</subject><subject>Monocarboxylic Acid Transporters - metabolism</subject><subject>Muscle Proteins - metabolism</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Protein Isoforms</subject><subject>Science & Technology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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F.</au><au>Schmitt, Fernando</au><au>Baltazar, Fátima</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas</atitle><jtitle>Virchows Archiv : an international journal of pathology</jtitle><stitle>Virchows Arch</stitle><addtitle>Virchows Arch</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>452</volume><issue>2</issue><spage>139</spage><epage>146</epage><pages>139-146</pages><issn>0945-6317</issn><eissn>1432-2307</eissn><abstract>Tumour cells are known to be highly glycolytic, thus producing high amounts of lactic acid. Monocarboxylate transporters (MCTs), by promoting the efflux of the accumulating acids, constitute one of the most important mechanisms in the maintenance of tumour intracellular pH. Since data concerning MCT expression in colorectal carcinomas (CRC) are scarce and controversial, the present study aimed to assess the expressions of MCT1, 2, and 4 in a well characterized series of CRC and assess their role in CRC carcinogenesis. CRC samples (126 cases) were analyzed for MCT1, MCT2, and MCT4 immunoexpression and findings correlated with clinico-pathological parameters. Expression of all MCT isoforms in tumour cells was significantly increased when compared to adjacent normal epithelium. Remarkably, there was a significant gain of membrane expression for MCT1 and MCT4 and loss of plasma membrane expression for MCT2 in tumour cells. Plasma membrane expression of MCT1 was directly related to the presence of vascular invasion. This is the larger study on MCT expression in CRC and evaluates for the first time its clinico-pathological significance. The increased expression of these transporters suggests an important role in CRC, which might justify their use, especially MCT1 and MCT4, as targets in CRC drug therapy
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| subjects | Adenocarcinoma, Mucinous - chemistry Adenocarcinoma, Mucinous - metabolism Adenocarcinoma, Mucinous - secondary Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - metabolism Carcinogenesis Cell Membrane - metabolism Child, Preschool Ciências Médicas Colorectal carcinoma Colorectal Neoplasms - chemistry Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Medicina Básica Medicine Medicine & Public Health Middle Aged Monocarboxylate transporter Monocarboxylic Acid Transporters - metabolism Muscle Proteins - metabolism Neoplasm Invasiveness Neoplasm Staging Original Article Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Protein Isoforms Science & Technology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Symporters - metabolism Tumors |
| title | Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas |
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