Pharmacokinetics of venlafaxine in treatment responders and non-responders: a retrospective analysis of a large naturalistic database

Purpose To assess in a large naturalistic sample, whether clinical response to a treatment with venlafaxine is associated with different patterns of plasma concentrations of active moiety, AM (sum of venlafaxine (VEN) and its active metabolite O-desmethylvenlafaxine (ODVEN)). Methods Applying a regr...

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Veröffentlicht in:	European journal of clinical pharmacology 2019-08, Vol.75 (8), p.1109-1116
Hauptverfasser:	Schoretsanitis, Georgios, Haen, Ekkehard, Gründer, Gerhard, Hiemke, Christoph, Endres, Katharina, Ridders, Florian, Correll, Christoph U., Paulzen, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Bipolar Disorder - blood Bipolar Disorder - diagnosis Bipolar Disorder - drug therapy Databases, Factual - statistics & numerical data Dependent variables Desvenlafaxine Succinate - pharmacokinetics Female Humans Independent variables Male Middle Aged Patients Pharmacokinetics Pharmacokinetics and Disposition Pharmacology/Toxicology Plasma Psychiatric Status Rating Scales - statistics & numerical data Regression coefficients Retrospective Studies Schizophrenia - blood Schizophrenia - diagnosis Schizophrenia - drug therapy Serotonin and Noradrenaline Reuptake Inhibitors - administration & dosage Serotonin and Noradrenaline Reuptake Inhibitors - pharmacokinetics Therapeutic drug monitoring Treatment Outcome Venlafaxine Venlafaxine Hydrochloride - administration & dosage Venlafaxine Hydrochloride - pharmacokinetics Young Adult
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