PBLG as a versatile liquid crystalline medium for anisotropic NMR data acquisition

Anisotropic NMR of small molecules has thus far utilized different solvent systems and alignment media to analyze molecules of different polarities. The value of utilizing PBLG liquid crystalline phase in a co-solvent system, expanding its range as a versatile alignment medium, is shown with three molecules of different polarities: strychnine, parthenolide, and sucrose. The chiral nematic phase of poly-γ-benzyl- l -glutamate (PBLG) formed in a chloroform-DMSO co-solvent system can be used as a versatile alignment medium for the acquisition of high quality anisotropic NMR data for molecules of varying polarities.