The Drosophila gene asteroid encodes a novel protein and displays dosage-sensitive interactions with Star and Egfr
The asteroid gene of Drosophila was found to lie within 189 bp of Star. Asteroid cDNA clones were isolated and sequenced and a single putative open reading frame was identified that encodes a novel protein of 815 amino acids with a calculated molecular mass of 93 kilodaltons. Using cDNA probes, aste...
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| Veröffentlicht in: | Genome 1998-04, Vol.41 (2), p.295-302 |
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| creator | Kotarski, Michael A Leonard, Deborah A Bennett, Sean A Bishop, Clifton P Wahn, Stephen D Sedore, Stacey A Shrader, Marissa |
| description | The asteroid gene of Drosophila was found to lie within 189 bp of Star. Asteroid cDNA clones were isolated and sequenced and a single putative open reading frame was identified that encodes a novel protein of 815 amino acids with a calculated molecular mass of 93 kilodaltons. Using cDNA probes, asteroid transcripts were localized to the proliferative tissues of embryos and to the mitotically active tissue anterior to the morphogenetic furrow in eye imaginal discs. Ribonuclease protection assays identified a mutation of asteroid that acts as a dominant enhancer of Star mutations and also enhances the Ellipse mutation, Egfr
E1
. Based on these data, a model for asteroid gene function in EGF receptor signaling is presented.Key words: Drosophila, asteroid, Star, EGF receptor, eye development. |
| doi_str_mv | 10.1139/g98-021 |
| format | Article |
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E1
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Based on these data, a model for asteroid gene function in EGF receptor signaling is presented.Key words: Drosophila, asteroid, Star, EGF receptor, eye development.</description><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Asteroids</subject><subject>Cell differentiation</subject><subject>Central nervous system</subject><subject>DNA-Binding Proteins - chemistry</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Drosophila - genetics</subject><subject>Drosophila Proteins</subject><subject>Embryonic growth stage</subject><subject>Embryos</subject><subject>Eyes & eyesight</subject><subject>Flies</subject><subject>Furrows</subject><subject>Gene Dosage</subject><subject>Genes, erbB-1</subject><subject>Genetics</subject><subject>Molecular Sequence Data</subject><subject>Mutagenesis</subject><subject>Mutation</subject><subject>Open Reading Frames</subject><subject>Phosphoproteins - 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Drosophila gene asteroid encodes a novel protein and displays dosage-sensitive interactions with Star and Egfr</title><author>Kotarski, Michael A ; Leonard, Deborah A ; Bennett, Sean A ; Bishop, Clifton P ; Wahn, Stephen D ; Sedore, Stacey A ; Shrader, Marissa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-5bbb923810e0e593322280754419bfd8d301b8d8da4d0df1ffd1914d7a621e903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Asteroids</topic><topic>Cell differentiation</topic><topic>Central nervous system</topic><topic>DNA-Binding Proteins - chemistry</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Drosophila - genetics</topic><topic>Drosophila Proteins</topic><topic>Embryonic growth stage</topic><topic>Embryos</topic><topic>Eyes & 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Egfr</atitle><jtitle>Genome</jtitle><addtitle>Génome</addtitle><date>1998-04</date><risdate>1998</risdate><volume>41</volume><issue>2</issue><spage>295</spage><epage>302</epage><pages>295-302</pages><issn>0831-2796</issn><eissn>1480-3321</eissn><coden>GENOE3</coden><abstract>The asteroid gene of Drosophila was found to lie within 189 bp of Star. Asteroid cDNA clones were isolated and sequenced and a single putative open reading frame was identified that encodes a novel protein of 815 amino acids with a calculated molecular mass of 93 kilodaltons. Using cDNA probes, asteroid transcripts were localized to the proliferative tissues of embryos and to the mitotically active tissue anterior to the morphogenetic furrow in eye imaginal discs. Ribonuclease protection assays identified a mutation of asteroid that acts as a dominant enhancer of Star mutations and also enhances the Ellipse mutation, Egfr
E1
. Based on these data, a model for asteroid gene function in EGF receptor signaling is presented.Key words: Drosophila, asteroid, Star, EGF receptor, eye development.</abstract><cop>Ottawa, Canada</cop><pub>NRC Research Press</pub><pmid>9644838</pmid><doi>10.1139/g98-021</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Genome, 1998-04, Vol.41 (2), p.295-302 |
| issn | 0831-2796 1480-3321 |
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| subjects | Amino Acid Sequence Amino acids Animals Asteroids Cell differentiation Central nervous system DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics Drosophila - genetics Drosophila Proteins Embryonic growth stage Embryos Eyes & eyesight Flies Furrows Gene Dosage Genes, erbB-1 Genetics Molecular Sequence Data Mutagenesis Mutation Open Reading Frames Phosphoproteins - genetics Proteins Restriction Mapping Signal Transduction - genetics |
| title | The Drosophila gene asteroid encodes a novel protein and displays dosage-sensitive interactions with Star and Egfr |
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