Cocaine, Ethanol, and Genotype Effects on Human Midbrain Serotonin Transporter Binding Sites and mRNA Levels

OBJECTIVE: Earlier platelet and postmortem brain studies have found alterations in serotonin transporter function in ethanol-abusing human subjects. The present investigation tested the hypothesis that brain serotonin transporter function is altered in chronic users of ethanol and cocaine, which mig...

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Veröffentlicht in:	The American journal of psychiatry 1998-02, Vol.155 (2), p.207-213
Hauptverfasser:	Little, Karley Y., McLaughlin, Daniel P., Zhang, Lian, Livermore, Cynthia S., Dalack, Gregory W., McFinton, Patrick R., DelProposto, Zachary S., Hill, Elizabeth, Cassin, Bader J., Watson, Stanley J., Cook, Edwin H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alcoholism - diagnosis Alcoholism - genetics Alcoholism - metabolism Autoradiography Biological and medical sciences Brain Carrier Proteins - analysis Carrier Proteins - genetics Carrier Proteins - metabolism Cocaine Cocaine-Related Disorders - diagnosis Cocaine-Related Disorders - genetics Cocaine-Related Disorders - metabolism Diagnosis, Dual (Psychiatry) Drug addictions Female Gene Frequency Genotype Humans Male Medical sciences Membrane Glycoproteins - analysis Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Transport Proteins Mesencephalon - chemistry Mesencephalon - metabolism Nerve Tissue Proteins Polymorphism, Genetic Psychiatry Radioligand Assay Raphe Nuclei - chemistry Raphe Nuclei - metabolism Receptors, Serotonin - analysis Receptors, Serotonin - metabolism RNA, Messenger - analysis Serotonin - analysis Serotonin - genetics Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins Substantia Nigra - chemistry Substantia Nigra - metabolism Toxicology
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