A review of 32 cases of tardive dystonia
OBJECTIVE: Tardive dystonia, historically combined with tardive dyskinesia, is now viewed as probably having a different pathophysiology, course, outcome, and treatment response than tardive dyskinesia. In addition, patients with tardive dystonia are reported to be younger, and most are men. This st...
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| Veröffentlicht in: | The American journal of psychiatry 1991-08, Vol.148 (8), p.1055-1059 |
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| container_title | The American journal of psychiatry |
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| creator | WOIJCIK, J. D FALK, W. E FINK, J. S COLE, J. O GELENBERG, A. J |
| description | OBJECTIVE: Tardive dystonia, historically combined with tardive
dyskinesia, is now viewed as probably having a different pathophysiology,
course, outcome, and treatment response than tardive dyskinesia. In
addition, patients with tardive dystonia are reported to be younger, and
most are men. This study evaluates characteristics of 32 patients with
tardive dystonia and compares results to other reports. METHOD: Twenty-four
patients had been referred for research purposes and were videotaped, while
eight had been followed clinically. Two of the authors reviewed all
available videotapes and clinical reports to assess the course of symptoms
over time. For global ratings and ratings of affected body parts, two
scales were used: the Abnormal Involuntary Movement Scale (AIMS) for
tardive dyskinesia and a similar scale for tardive dystonia. The method of
case finding does not provide incidence or prevalence data for tardive
dystonia. RESULTS: Fifty-nine percent of the patients experienced onset of
tardive dystonia symptoms within 6 years of antipsychotic drug exposure;
women had a shorter exposure time. No patient had complete remission of
tardive dystonia symptoms, and 22 were moderately or severely impaired when
their movements were most prominent. CONCLUSIONS: While epidemiological
studies of tardive dystonia have yet to be performed, these results support
the observations of others that most patients with tardive dystonia are
men, have a short history of exposure to antipsychotic drugs, and may
initially present with blepharospasm. Tardive dystonia rarely remits
completely, can cause notable disability, and may partially respond to
anticholinergic agents. |
| doi_str_mv | 10.1176/ajp.148.8.1055 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_220473067</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1777198</sourcerecordid><originalsourceid>FETCH-LOGICAL-a410t-d97fb14c81258353d16536834f2ce81972d64f3eb2927542db101cec05c01afc3</originalsourceid><addsrcrecordid>eNp1kM1LwzAUwIMoc06v3oSiHgRpzXtpmvQ4hl8w8KLgLaRpCh3bWpNusv_elA71oLm8PN7vffAj5BxoAiCyO71oE0hlIhOgnB-QMXDGY4EoD8mYUopxztn7MTnxfhFSygSOyAgyIZBlY3IzjZzd1vYzaqqIYWS0t77_d9qV9dZG5c53zbrWp-So0ktvz_ZxQt4e7l9nT_H85fF5Np3HOgXaxWUuqgJSIwG5ZJyVkHGWSZZWaKyEXGCZpRWzBeYoeIplARSMNZQbCroybEIuh7mtaz421ndq0WzcOqxUiDQVjGYiQFf_QcCAZgiAGKhkoIxrvHe2Uq2rV9rtFFDVy1NBngrylFS9vNBwsR-7KVa2_MEHW6F-va9rb_Sycnptav-NcZ6H1193O2C6betfl_299Asls4CW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1310621122</pqid></control><display><type>article</type><title>A review of 32 cases of tardive dystonia</title><source>MEDLINE</source><source>Psychiatry Legacy Collection Online Journals 1844-1996</source><source>Periodicals Index Online</source><creator>WOIJCIK, J. D ; FALK, W. E ; FINK, J. S ; COLE, J. O ; GELENBERG, A. J</creator><creatorcontrib>WOIJCIK, J. D ; FALK, W. E ; FINK, J. S ; COLE, J. O ; GELENBERG, A. J</creatorcontrib><description>OBJECTIVE: Tardive dystonia, historically combined with tardive
dyskinesia, is now viewed as probably having a different pathophysiology,
course, outcome, and treatment response than tardive dyskinesia. In
addition, patients with tardive dystonia are reported to be younger, and
most are men. This study evaluates characteristics of 32 patients with
tardive dystonia and compares results to other reports. METHOD: Twenty-four
patients had been referred for research purposes and were videotaped, while
eight had been followed clinically. Two of the authors reviewed all
available videotapes and clinical reports to assess the course of symptoms
over time. For global ratings and ratings of affected body parts, two
scales were used: the Abnormal Involuntary Movement Scale (AIMS) for
tardive dyskinesia and a similar scale for tardive dystonia. The method of
case finding does not provide incidence or prevalence data for tardive
dystonia. RESULTS: Fifty-nine percent of the patients experienced onset of
tardive dystonia symptoms within 6 years of antipsychotic drug exposure;
women had a shorter exposure time. No patient had complete remission of
tardive dystonia symptoms, and 22 were moderately or severely impaired when
their movements were most prominent. CONCLUSIONS: While epidemiological
studies of tardive dystonia have yet to be performed, these results support
the observations of others that most patients with tardive dystonia are
men, have a short history of exposure to antipsychotic drugs, and may
initially present with blepharospasm. Tardive dystonia rarely remits
completely, can cause notable disability, and may partially respond to
anticholinergic agents.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/ajp.148.8.1055</identifier><identifier>PMID: 1677236</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Adult ; Age Factors ; Aged ; Antipsychotic Agents - administration & dosage ; Antipsychotic Agents - adverse effects ; Biological and medical sciences ; Diagnosis, Differential ; Drug toxicity and drugs side effects treatment ; Dyskinesia, Drug-Induced - diagnosis ; Dyskinesia, Drug-Induced - etiology ; Dyskinesia, Drug-Induced - physiopathology ; Dystonia - chemically induced ; Dystonia - diagnosis ; Dystonia - physiopathology ; Female ; Humans ; Male ; Medical disorders ; Medical research ; Medical sciences ; Middle Aged ; Mood Disorders - drug therapy ; Neurologic Examination ; Pharmacology. Drug treatments ; Psychotic Disorders - drug therapy ; Sex Factors ; Time Factors ; Toxicity: nervous system and muscle</subject><ispartof>The American journal of psychiatry, 1991-08, Vol.148 (8), p.1055-1059</ispartof><rights>1992 INIST-CNRS</rights><rights>Copyright American Psychiatric Association Aug 1991</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a410t-d97fb14c81258353d16536834f2ce81972d64f3eb2927542db101cec05c01afc3</citedby><cites>FETCH-LOGICAL-a410t-d97fb14c81258353d16536834f2ce81972d64f3eb2927542db101cec05c01afc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/ajp.148.8.1055$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/ajp.148.8.1055$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,776,780,2845,21609,27848,27903,27904,77537,77538</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5599997$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1677236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WOIJCIK, J. D</creatorcontrib><creatorcontrib>FALK, W. E</creatorcontrib><creatorcontrib>FINK, J. S</creatorcontrib><creatorcontrib>COLE, J. O</creatorcontrib><creatorcontrib>GELENBERG, A. J</creatorcontrib><title>A review of 32 cases of tardive dystonia</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: Tardive dystonia, historically combined with tardive
dyskinesia, is now viewed as probably having a different pathophysiology,
course, outcome, and treatment response than tardive dyskinesia. In
addition, patients with tardive dystonia are reported to be younger, and
most are men. This study evaluates characteristics of 32 patients with
tardive dystonia and compares results to other reports. METHOD: Twenty-four
patients had been referred for research purposes and were videotaped, while
eight had been followed clinically. Two of the authors reviewed all
available videotapes and clinical reports to assess the course of symptoms
over time. For global ratings and ratings of affected body parts, two
scales were used: the Abnormal Involuntary Movement Scale (AIMS) for
tardive dyskinesia and a similar scale for tardive dystonia. The method of
case finding does not provide incidence or prevalence data for tardive
dystonia. RESULTS: Fifty-nine percent of the patients experienced onset of
tardive dystonia symptoms within 6 years of antipsychotic drug exposure;
women had a shorter exposure time. No patient had complete remission of
tardive dystonia symptoms, and 22 were moderately or severely impaired when
their movements were most prominent. CONCLUSIONS: While epidemiological
studies of tardive dystonia have yet to be performed, these results support
the observations of others that most patients with tardive dystonia are
men, have a short history of exposure to antipsychotic drugs, and may
initially present with blepharospasm. Tardive dystonia rarely remits
completely, can cause notable disability, and may partially respond to
anticholinergic agents.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Antipsychotic Agents - administration & dosage</subject><subject>Antipsychotic Agents - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Diagnosis, Differential</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Dyskinesia, Drug-Induced - diagnosis</subject><subject>Dyskinesia, Drug-Induced - etiology</subject><subject>Dyskinesia, Drug-Induced - physiopathology</subject><subject>Dystonia - chemically induced</subject><subject>Dystonia - diagnosis</subject><subject>Dystonia - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical disorders</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood Disorders - drug therapy</subject><subject>Neurologic Examination</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychotic Disorders - drug therapy</subject><subject>Sex Factors</subject><subject>Time Factors</subject><subject>Toxicity: nervous system and muscle</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNp1kM1LwzAUwIMoc06v3oSiHgRpzXtpmvQ4hl8w8KLgLaRpCh3bWpNusv_elA71oLm8PN7vffAj5BxoAiCyO71oE0hlIhOgnB-QMXDGY4EoD8mYUopxztn7MTnxfhFSygSOyAgyIZBlY3IzjZzd1vYzaqqIYWS0t77_d9qV9dZG5c53zbrWp-So0ktvz_ZxQt4e7l9nT_H85fF5Np3HOgXaxWUuqgJSIwG5ZJyVkHGWSZZWaKyEXGCZpRWzBeYoeIplARSMNZQbCroybEIuh7mtaz421ndq0WzcOqxUiDQVjGYiQFf_QcCAZgiAGKhkoIxrvHe2Uq2rV9rtFFDVy1NBngrylFS9vNBwsR-7KVa2_MEHW6F-va9rb_Sycnptav-NcZ6H1193O2C6betfl_299Asls4CW</recordid><startdate>19910801</startdate><enddate>19910801</enddate><creator>WOIJCIK, J. D</creator><creator>FALK, W. E</creator><creator>FINK, J. 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D ; FALK, W. E ; FINK, J. S ; COLE, J. O ; GELENBERG, A. 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D</au><au>FALK, W. E</au><au>FINK, J. S</au><au>COLE, J. O</au><au>GELENBERG, A. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A review of 32 cases of tardive dystonia</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>1991-08-01</date><risdate>1991</risdate><volume>148</volume><issue>8</issue><spage>1055</spage><epage>1059</epage><pages>1055-1059</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: Tardive dystonia, historically combined with tardive
dyskinesia, is now viewed as probably having a different pathophysiology,
course, outcome, and treatment response than tardive dyskinesia. In
addition, patients with tardive dystonia are reported to be younger, and
most are men. This study evaluates characteristics of 32 patients with
tardive dystonia and compares results to other reports. METHOD: Twenty-four
patients had been referred for research purposes and were videotaped, while
eight had been followed clinically. Two of the authors reviewed all
available videotapes and clinical reports to assess the course of symptoms
over time. For global ratings and ratings of affected body parts, two
scales were used: the Abnormal Involuntary Movement Scale (AIMS) for
tardive dyskinesia and a similar scale for tardive dystonia. The method of
case finding does not provide incidence or prevalence data for tardive
dystonia. RESULTS: Fifty-nine percent of the patients experienced onset of
tardive dystonia symptoms within 6 years of antipsychotic drug exposure;
women had a shorter exposure time. No patient had complete remission of
tardive dystonia symptoms, and 22 were moderately or severely impaired when
their movements were most prominent. CONCLUSIONS: While epidemiological
studies of tardive dystonia have yet to be performed, these results support
the observations of others that most patients with tardive dystonia are
men, have a short history of exposure to antipsychotic drugs, and may
initially present with blepharospasm. Tardive dystonia rarely remits
completely, can cause notable disability, and may partially respond to
anticholinergic agents.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>1677236</pmid><doi>10.1176/ajp.148.8.1055</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-953X |
| ispartof | The American journal of psychiatry, 1991-08, Vol.148 (8), p.1055-1059 |
| issn | 0002-953X 1535-7228 |
| language | eng |
| recordid | cdi_proquest_journals_220473067 |
| source | MEDLINE; Psychiatry Legacy Collection Online Journals 1844-1996; Periodicals Index Online |
| subjects | Adult Age Factors Aged Antipsychotic Agents - administration & dosage Antipsychotic Agents - adverse effects Biological and medical sciences Diagnosis, Differential Drug toxicity and drugs side effects treatment Dyskinesia, Drug-Induced - diagnosis Dyskinesia, Drug-Induced - etiology Dyskinesia, Drug-Induced - physiopathology Dystonia - chemically induced Dystonia - diagnosis Dystonia - physiopathology Female Humans Male Medical disorders Medical research Medical sciences Middle Aged Mood Disorders - drug therapy Neurologic Examination Pharmacology. Drug treatments Psychotic Disorders - drug therapy Sex Factors Time Factors Toxicity: nervous system and muscle |
| title | A review of 32 cases of tardive dystonia |
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