Prospective evaluation of panic potentiation following 35% CO2 challenge in nonclinical subjects
OBJECTIVE: The authors examined the effect of panic provocation on the subsequent development of panic attacks and panic disorder in nonclinical subjects with no history of spontaneous panic. METHOD: Sixty-two subjects who had completed a study examining fearful responses to a single vital capacity...
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| Veröffentlicht in: | The American journal of psychiatry 1996-06, Vol.153 (6), p.823-825 |
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| container_title | The American journal of psychiatry |
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| creator | HARRINGTON, P. J SCHMIDT, N. B TELCH, M. J |
| description | OBJECTIVE: The authors examined the effect of panic provocation on the
subsequent development of panic attacks and panic disorder in nonclinical
subjects with no history of spontaneous panic. METHOD: Sixty-two subjects
who had completed a study examining fearful responses to a single vital
capacity inhalation of 35% CO2 were reevaluated 1 year following the
challenge test. RESULTS: Challenge- induced panic was not related to the
later development of panic or panic disorder. According to the Structured
Clinical Interview for DSM- III-R--Non-Patient Edition, none of the
subjects met DSM-III-R criteria for panic disorder and only six subjects
reported spontaneous panic during the year after panic provocation. Of the
six subjects who experienced spontaneous panic, two had panicked in
response to the CO2 challenge. CONCLUSIONS: The experimental provocation of
panic in nonclinical subjects appears to be a safe research paradigm for
exploring the psychopathogenicity of panic disorder. |
| doi_str_mv | 10.1176/ajp.153.6.823 |
| format | Article |
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subsequent development of panic attacks and panic disorder in nonclinical
subjects with no history of spontaneous panic. METHOD: Sixty-two subjects
who had completed a study examining fearful responses to a single vital
capacity inhalation of 35% CO2 were reevaluated 1 year following the
challenge test. RESULTS: Challenge- induced panic was not related to the
later development of panic or panic disorder. According to the Structured
Clinical Interview for DSM- III-R--Non-Patient Edition, none of the
subjects met DSM-III-R criteria for panic disorder and only six subjects
reported spontaneous panic during the year after panic provocation. Of the
six subjects who experienced spontaneous panic, two had panicked in
response to the CO2 challenge. CONCLUSIONS: The experimental provocation of
panic in nonclinical subjects appears to be a safe research paradigm for
exploring the psychopathogenicity of panic disorder.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/ajp.153.6.823</identifier><identifier>PMID: 8633699</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Administration, Inhalation ; Adolescent ; Adult ; Adult and adolescent clinical studies ; Anxiety disorders. Neuroses ; Biological and medical sciences ; Carbon Dioxide - administration & dosage ; Carbon Dioxide - adverse effects ; Female ; Follow-Up Studies ; Humans ; Male ; Medical sciences ; Mental disorders ; Panic disorder ; Panic Disorder - chemically induced ; Panic Disorder - diagnosis ; Panic Disorder - epidemiology ; Prospective Studies ; Psychiatric Status Rating Scales ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry</subject><ispartof>The American journal of psychiatry, 1996-06, Vol.153 (6), p.823-825</ispartof><rights>1996 INIST-CNRS</rights><rights>Copyright American Psychiatric Association Jun 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a407t-61ef34868853927c5eea4506a373819ca0e5e67cb518652acd41c5dc0c932f4d3</citedby><cites>FETCH-LOGICAL-a407t-61ef34868853927c5eea4506a373819ca0e5e67cb518652acd41c5dc0c932f4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/ajp.153.6.823$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/ajp.153.6.823$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,780,784,2859,21629,27869,27924,27925,77791,77792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3128283$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8633699$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HARRINGTON, P. J</creatorcontrib><creatorcontrib>SCHMIDT, N. B</creatorcontrib><creatorcontrib>TELCH, M. J</creatorcontrib><title>Prospective evaluation of panic potentiation following 35% CO2 challenge in nonclinical subjects</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: The authors examined the effect of panic provocation on the
subsequent development of panic attacks and panic disorder in nonclinical
subjects with no history of spontaneous panic. METHOD: Sixty-two subjects
who had completed a study examining fearful responses to a single vital
capacity inhalation of 35% CO2 were reevaluated 1 year following the
challenge test. RESULTS: Challenge- induced panic was not related to the
later development of panic or panic disorder. According to the Structured
Clinical Interview for DSM- III-R--Non-Patient Edition, none of the
subjects met DSM-III-R criteria for panic disorder and only six subjects
reported spontaneous panic during the year after panic provocation. Of the
six subjects who experienced spontaneous panic, two had panicked in
response to the CO2 challenge. CONCLUSIONS: The experimental provocation of
panic in nonclinical subjects appears to be a safe research paradigm for
exploring the psychopathogenicity of panic disorder.</description><subject>Administration, Inhalation</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Anxiety disorders. Neuroses</subject><subject>Biological and medical sciences</subject><subject>Carbon Dioxide - administration & dosage</subject><subject>Carbon Dioxide - adverse effects</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental disorders</subject><subject>Panic disorder</subject><subject>Panic Disorder - chemically induced</subject><subject>Panic Disorder - diagnosis</subject><subject>Panic Disorder - epidemiology</subject><subject>Prospective Studies</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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Neuroses</topic><topic>Biological and medical sciences</topic><topic>Carbon Dioxide - administration & dosage</topic><topic>Carbon Dioxide - adverse effects</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental disorders</topic><topic>Panic disorder</topic><topic>Panic Disorder - chemically induced</topic><topic>Panic Disorder - diagnosis</topic><topic>Panic Disorder - epidemiology</topic><topic>Prospective Studies</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HARRINGTON, P. J</creatorcontrib><creatorcontrib>SCHMIDT, N. B</creatorcontrib><creatorcontrib>TELCH, M. 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J</au><au>SCHMIDT, N. B</au><au>TELCH, M. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective evaluation of panic potentiation following 35% CO2 challenge in nonclinical subjects</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>1996-06-01</date><risdate>1996</risdate><volume>153</volume><issue>6</issue><spage>823</spage><epage>825</epage><pages>823-825</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: The authors examined the effect of panic provocation on the
subsequent development of panic attacks and panic disorder in nonclinical
subjects with no history of spontaneous panic. METHOD: Sixty-two subjects
who had completed a study examining fearful responses to a single vital
capacity inhalation of 35% CO2 were reevaluated 1 year following the
challenge test. RESULTS: Challenge- induced panic was not related to the
later development of panic or panic disorder. According to the Structured
Clinical Interview for DSM- III-R--Non-Patient Edition, none of the
subjects met DSM-III-R criteria for panic disorder and only six subjects
reported spontaneous panic during the year after panic provocation. Of the
six subjects who experienced spontaneous panic, two had panicked in
response to the CO2 challenge. CONCLUSIONS: The experimental provocation of
panic in nonclinical subjects appears to be a safe research paradigm for
exploring the psychopathogenicity of panic disorder.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>8633699</pmid><doi>10.1176/ajp.153.6.823</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-953X |
| ispartof | The American journal of psychiatry, 1996-06, Vol.153 (6), p.823-825 |
| issn | 0002-953X 1535-7228 |
| language | eng |
| recordid | cdi_proquest_journals_220466108 |
| source | MEDLINE; Psychiatry Legacy Collection Online Journals 1844-1996; Periodicals Index Online |
| subjects | Administration, Inhalation Adolescent Adult Adult and adolescent clinical studies Anxiety disorders. Neuroses Biological and medical sciences Carbon Dioxide - administration & dosage Carbon Dioxide - adverse effects Female Follow-Up Studies Humans Male Medical sciences Mental disorders Panic disorder Panic Disorder - chemically induced Panic Disorder - diagnosis Panic Disorder - epidemiology Prospective Studies Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry |
| title | Prospective evaluation of panic potentiation following 35% CO2 challenge in nonclinical subjects |
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