Association of an Interleukin-1 Genetic Polymorphism With Altered Brain Structure in Patients With Schizophrenia
OBJECTIVE: This study investigated the effect on brain morphology of an interleukin-1 genetic polymorphism (C→T transition at position -511) in patients with schizophrenia. METHOD: In vivo magnetic resonance imaging and genotype analysis were used in the examination of 44 male schizophrenic patients...
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| Veröffentlicht in: | The American journal of psychiatry 2001-08, Vol.158 (8), p.1316-1319 |
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| container_title | The American journal of psychiatry |
| container_volume | 158 |
| creator | Meisenzahl, Eva M. Rujescu, Dan Kirner, Andre Giegling, Ina Kathmann, Norbert Leinsinger, Gerda Maag, Klaus Hegerl, Ulrich Hahn, Klaus Möller, Hans-Jürgen |
| description | OBJECTIVE: This study investigated the effect on brain morphology of an interleukin-1 genetic polymorphism (C→T transition at position -511) in patients with schizophrenia. METHOD: In vivo magnetic resonance imaging and genotype analysis were used in the examination of 44 male schizophrenic patients and 48 healthy male comparison subjects. RESULTS: No association between the interleukin-1 polymorphism and schizophrenia was detected. Within the patient group, bifrontal-temporal gray matter volume deficits and generalized white matter tissue deficits in allele 2 carriers (genotype T T or C T) were found. In contrast, the interleukin-1 polymorphism had no influence on brain morphology within the healthy subjects. CONCLUSIONS: The data suggest that allele 2 within the promoter region of the interleukin-1 gene at position -511 contributes to structural brain alterations in patients with schizophrenia. |
| doi_str_mv | 10.1176/appi.ajp.158.8.1316 |
| format | Article |
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METHOD: In vivo magnetic resonance imaging and genotype analysis were used in the examination of 44 male schizophrenic patients and 48 healthy male comparison subjects. RESULTS: No association between the interleukin-1 polymorphism and schizophrenia was detected. Within the patient group, bifrontal-temporal gray matter volume deficits and generalized white matter tissue deficits in allele 2 carriers (genotype T T or C T) were found. In contrast, the interleukin-1 polymorphism had no influence on brain morphology within the healthy subjects. CONCLUSIONS: The data suggest that allele 2 within the promoter region of the interleukin-1 gene at position -511 contributes to structural brain alterations in patients with schizophrenia.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.158.8.1316</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington: American Psychiatric Publishing</publisher><subject>Brain ; Genetics ; Men ; Neurology ; Patients ; Schizophrenia</subject><ispartof>The American journal of psychiatry, 2001-08, Vol.158 (8), p.1316-1319</ispartof><rights>Copyright American Psychiatric Association Aug 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/appi.ajp.158.8.1316$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/appi.ajp.158.8.1316$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,780,784,21625,21626,21627,27923,27924,77565,77570</link.rule.ids></links><search><creatorcontrib>Meisenzahl, Eva M.</creatorcontrib><creatorcontrib>Rujescu, Dan</creatorcontrib><creatorcontrib>Kirner, Andre</creatorcontrib><creatorcontrib>Giegling, Ina</creatorcontrib><creatorcontrib>Kathmann, Norbert</creatorcontrib><creatorcontrib>Leinsinger, Gerda</creatorcontrib><creatorcontrib>Maag, Klaus</creatorcontrib><creatorcontrib>Hegerl, Ulrich</creatorcontrib><creatorcontrib>Hahn, Klaus</creatorcontrib><creatorcontrib>Möller, Hans-Jürgen</creatorcontrib><title>Association of an Interleukin-1 Genetic Polymorphism With Altered Brain Structure in Patients With Schizophrenia</title><title>The American journal of psychiatry</title><description>OBJECTIVE: This study investigated the effect on brain morphology of an interleukin-1 genetic polymorphism (C→T transition at position -511) in patients with schizophrenia. METHOD: In vivo magnetic resonance imaging and genotype analysis were used in the examination of 44 male schizophrenic patients and 48 healthy male comparison subjects. RESULTS: No association between the interleukin-1 polymorphism and schizophrenia was detected. Within the patient group, bifrontal-temporal gray matter volume deficits and generalized white matter tissue deficits in allele 2 carriers (genotype T T or C T) were found. In contrast, the interleukin-1 polymorphism had no influence on brain morphology within the healthy subjects. CONCLUSIONS: The data suggest that allele 2 within the promoter region of the interleukin-1 gene at position -511 contributes to structural brain alterations in patients with schizophrenia.</description><subject>Brain</subject><subject>Genetics</subject><subject>Men</subject><subject>Neurology</subject><subject>Patients</subject><subject>Schizophrenia</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNpFkFFLwzAUhYMoOKe_wJfge2tu0jTZ4xw6B4KDDfStpE3KMrukNumD_nozJ_h0OZePc-BD6BZIDiDKe9X3Nlf7Pgcuc5kDg_IMTYAznglK5TmaEEJoNuPs_RJdhbBPkTBBJ6ifh-Abq6L1DvsWK4dXLpqhM-OHdRngpXEm2gavffd18EO_s-GA32zc4XmXOKPxw6Csw5s4jE0cB4NTWKc-42I4gZtmZ799vxuMs-oaXbSqC-bm707R9ulxu3jOXl6Xq8X8JVOl5FmhJONNW7NaC2I0aXhZC1pLJoUGTogkQglWtqU2RQO6oBIANNOtUjBrCbApujvV9oP_HE2I1d6Pg0uLFaWkKCkRPEHkBB39_QNAqqPV6vebrFbJaiWro1X2AysHbfk</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>Meisenzahl, Eva M.</creator><creator>Rujescu, Dan</creator><creator>Kirner, Andre</creator><creator>Giegling, Ina</creator><creator>Kathmann, Norbert</creator><creator>Leinsinger, Gerda</creator><creator>Maag, Klaus</creator><creator>Hegerl, Ulrich</creator><creator>Hahn, Klaus</creator><creator>Möller, Hans-Jürgen</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20010801</creationdate><title>Association of an Interleukin-1 Genetic Polymorphism With Altered Brain Structure in Patients With Schizophrenia</title><author>Meisenzahl, Eva M. ; Rujescu, Dan ; Kirner, Andre ; Giegling, Ina ; Kathmann, Norbert ; Leinsinger, Gerda ; Maag, Klaus ; Hegerl, Ulrich ; Hahn, Klaus ; Möller, Hans-Jürgen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a685-4a835cfb3bd70ed0c56b72b8387d1500807a736f6de4c1d428111d3dfaa19f013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Brain</topic><topic>Genetics</topic><topic>Men</topic><topic>Neurology</topic><topic>Patients</topic><topic>Schizophrenia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meisenzahl, Eva M.</creatorcontrib><creatorcontrib>Rujescu, Dan</creatorcontrib><creatorcontrib>Kirner, Andre</creatorcontrib><creatorcontrib>Giegling, Ina</creatorcontrib><creatorcontrib>Kathmann, Norbert</creatorcontrib><creatorcontrib>Leinsinger, Gerda</creatorcontrib><creatorcontrib>Maag, Klaus</creatorcontrib><creatorcontrib>Hegerl, Ulrich</creatorcontrib><creatorcontrib>Hahn, Klaus</creatorcontrib><creatorcontrib>Möller, Hans-Jürgen</creatorcontrib><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>The American journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meisenzahl, Eva M.</au><au>Rujescu, Dan</au><au>Kirner, Andre</au><au>Giegling, Ina</au><au>Kathmann, Norbert</au><au>Leinsinger, Gerda</au><au>Maag, Klaus</au><au>Hegerl, Ulrich</au><au>Hahn, Klaus</au><au>Möller, Hans-Jürgen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of an Interleukin-1 Genetic Polymorphism With Altered Brain Structure in Patients With Schizophrenia</atitle><jtitle>The American journal of psychiatry</jtitle><date>2001-08-01</date><risdate>2001</risdate><volume>158</volume><issue>8</issue><spage>1316</spage><epage>1319</epage><pages>1316-1319</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: This study investigated the effect on brain morphology of an interleukin-1 genetic polymorphism (C→T transition at position -511) in patients with schizophrenia. METHOD: In vivo magnetic resonance imaging and genotype analysis were used in the examination of 44 male schizophrenic patients and 48 healthy male comparison subjects. RESULTS: No association between the interleukin-1 polymorphism and schizophrenia was detected. Within the patient group, bifrontal-temporal gray matter volume deficits and generalized white matter tissue deficits in allele 2 carriers (genotype T T or C T) were found. In contrast, the interleukin-1 polymorphism had no influence on brain morphology within the healthy subjects. CONCLUSIONS: The data suggest that allele 2 within the promoter region of the interleukin-1 gene at position -511 contributes to structural brain alterations in patients with schizophrenia.</abstract><cop>Washington</cop><pub>American Psychiatric Publishing</pub><doi>10.1176/appi.ajp.158.8.1316</doi><tpages>4</tpages></addata></record> |
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| source | American Psychiatric Publishing Journals (1997-Present); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Brain Genetics Men Neurology Patients Schizophrenia |
| title | Association of an Interleukin-1 Genetic Polymorphism With Altered Brain Structure in Patients With Schizophrenia |
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