Prevention of ochratoxin A‐induced oxidative stress‐mediated apoptotic processes and impairment of embryonic development in mouse blastocysts by liquiritigenin

Ochratoxin A (OTA), a mycotoxin constituent of a range of food commodities, including coffee, wine, beer, grains, and spices, exerts toxicological and pathological effects in vivo, such as nephrotoxicity, hepatotoxicity, and immunotoxicity. In a previous report, we highlighted the potential of OTA t...

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Veröffentlicht in:	Environmental toxicology 2019-05, Vol.34 (5), p.573-584
Hauptverfasser:	Huang, Chien‐Hsun, Wang, Fu‐Ting, Chan, Wen‐Hsiung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal embryos Animal models Animals Apoptosis Apoptosis - drug effects Beer Biocompatibility Blastocyst - drug effects Blastocyst - metabolism Blastocyst - pathology Blastocysts Body weight loss Caspase Cell proliferation Cell Proliferation - drug effects Coffee Commodities Dams Embryogenesis Embryonic development Embryonic Development - drug effects Embryonic growth stage Embryos Female Fetuses Flavanones - pharmacology Hepatotoxicity Immunotoxicity Impairment In vivo methods and tests Injection Intravenous administration Liquiritigenin Membrane potential Membrane Potential, Mitochondrial - drug effects Mice Mitochondria Mycotoxins Ochratoxin A Ochratoxins - toxicity Oxidative stress Oxidative Stress - drug effects Pathological effects Pregnancy Proliferation Protective Agents - pharmacology Reactive oxygen species Regulatory mechanisms (biology) Spices Toxicology Weight Weight loss Wine Zygotes
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