Synthesis and Antitumor Evaluation of Novel Alkylated Hydantoin and Thiohydantoin Derivatives
New alkylated hydantoin as well as 2-thiohydantoins were synthesized for broadening the library of compounds screened for antitumor activity. Antitumor activity of the new compounds was evaluated against breast cancer cell line (MCF-7) and demonstrated moderate to good activity.
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| Veröffentlicht in: | Russian journal of general chemistry 2019-02, Vol.89 (2), p.357-363 |
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| container_end_page | 363 |
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| container_issue | 2 |
| container_start_page | 357 |
| container_title | Russian journal of general chemistry |
| container_volume | 89 |
| creator | Ahmed, A. H. Ebead, A. Afifi, H. Abdel-Rahman, A. A.-H. |
| description | New alkylated hydantoin as well as 2-thiohydantoins were synthesized for broadening the library of compounds screened for antitumor activity. Antitumor activity of the new compounds was evaluated against breast cancer cell line (MCF-7) and demonstrated moderate to good activity. |
| doi_str_mv | 10.1134/S1070363219020294 |
| format | Article |
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| ispartof | Russian journal of general chemistry, 2019-02, Vol.89 (2), p.357-363 |
| issn | 1070-3632 1608-3350 |
| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Alkylation Anticancer properties Chemistry Chemistry and Materials Science Chemistry/Food Science Hydantoin |
| title | Synthesis and Antitumor Evaluation of Novel Alkylated Hydantoin and Thiohydantoin Derivatives |
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