Drug-induced thrombocytopenia in the coronary care unit
Drug-induced thrombocytopenia is a phenomenon that causes significant morbidity and mortality among patients. Practitioners should be able to recognize the clinical manifestations of drug-induced thrombocytopenia, differentiate it from other causes, and manage it appropriately. Numerous case reports...
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| Veröffentlicht in: | Journal of thrombosis and thrombolysis 2000-10, Vol.10 (2), p.155-167 |
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| container_title | Journal of thrombosis and thrombolysis |
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| creator | PATNODE, Nicole M GANDHI, Pritesh J |
| description | Drug-induced thrombocytopenia is a phenomenon that causes significant morbidity and mortality among patients. Practitioners should be able to recognize the clinical manifestations of drug-induced thrombocytopenia, differentiate it from other causes, and manage it appropriately. Numerous case reports have documented drug-induced causes of thrombocytopenia. The following article focuses on the characteristics and management of drug-induced thrombocytopenia secondary to medications commonly encountered in the coronary care unit. Pharmacotherapeutic agents that are most commonly implicated in this setting include ticlopidine, unfractioned heparin, glycoprotein (GP)IIb/IIIa inhibitors, H(2)-receptor antagonists, quinidine and antibiotics. Case reports were obtained through a comprehensive search of the Medicine database and subsequently complemented by bibliographic reviews of the agents just specified. Reports that exhibited possible, probable, and definite associations with drug-induced thrombocytopenia are included in the article. |
| doi_str_mv | 10.1023/A:1018766610796 |
| format | Article |
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Practitioners should be able to recognize the clinical manifestations of drug-induced thrombocytopenia, differentiate it from other causes, and manage it appropriately. Numerous case reports have documented drug-induced causes of thrombocytopenia. The following article focuses on the characteristics and management of drug-induced thrombocytopenia secondary to medications commonly encountered in the coronary care unit. Pharmacotherapeutic agents that are most commonly implicated in this setting include ticlopidine, unfractioned heparin, glycoprotein (GP)IIb/IIIa inhibitors, H(2)-receptor antagonists, quinidine and antibiotics. Case reports were obtained through a comprehensive search of the Medicine database and subsequently complemented by bibliographic reviews of the agents just specified. 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Drug treatments ; Platelet Aggregation Inhibitors - adverse effects ; Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors ; Thrombocytopenia - chemically induced ; Thrombocytopenia - complications ; Thrombocytopenia - etiology ; Ticlopidine - adverse effects ; Toxicity: blood</subject><ispartof>Journal of thrombosis and thrombolysis, 2000-10, Vol.10 (2), p.155-167</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Kluwer Academic Publishers Oct 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c309t-3467a554b07d8def0968078e745894803a4ce3d82599929654e22379c44cc6c83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1523864$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11005938$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PATNODE, Nicole M</creatorcontrib><creatorcontrib>GANDHI, Pritesh J</creatorcontrib><title>Drug-induced thrombocytopenia in the coronary care unit</title><title>Journal of thrombosis and thrombolysis</title><addtitle>J Thromb Thrombolysis</addtitle><description>Drug-induced thrombocytopenia is a phenomenon that causes significant morbidity and mortality among patients. Practitioners should be able to recognize the clinical manifestations of drug-induced thrombocytopenia, differentiate it from other causes, and manage it appropriately. Numerous case reports have documented drug-induced causes of thrombocytopenia. The following article focuses on the characteristics and management of drug-induced thrombocytopenia secondary to medications commonly encountered in the coronary care unit. Pharmacotherapeutic agents that are most commonly implicated in this setting include ticlopidine, unfractioned heparin, glycoprotein (GP)IIb/IIIa inhibitors, H(2)-receptor antagonists, quinidine and antibiotics. Case reports were obtained through a comprehensive search of the Medicine database and subsequently complemented by bibliographic reviews of the agents just specified. 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Drug treatments</subject><subject>Platelet Aggregation Inhibitors - adverse effects</subject><subject>Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors</subject><subject>Thrombocytopenia - chemically induced</subject><subject>Thrombocytopenia - complications</subject><subject>Thrombocytopenia - etiology</subject><subject>Ticlopidine - adverse effects</subject><subject>Toxicity: blood</subject><issn>0929-5305</issn><issn>1573-742X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpFz01Lw0AQBuBFFBurZ28SxGt0dmc_vZXWLyh4UfAWtputpjS7cZMc-u8NGPE0MDy88w4hlxRuKTC8W9xToFpJKSkoI49IRoXCQnH2cUwyMMwUAkHMyFnX7QDAGGCnZEYpgDCoM6JWafgs6lANzld5_5Vis4nu0MfWh9rmdRh3PncxxWDTIXc2-XwIdX9OTrZ23_mLac7J--PD2_K5WL8-vSwX68IhmL5ALpUVgm9AVbryWzBSg9JecaEN14CWO4-VZsKYsawU3DOGyjjOnZNO45xc_-a2KX4PvuvLXRxSGE-WjAEKJiiO6GpCw6bxVdmmuhnbln9vjuBmArZzdr9NNri6-3eCoZYcfwCB4F5q</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>PATNODE, Nicole M</creator><creator>GANDHI, Pritesh J</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20001001</creationdate><title>Drug-induced thrombocytopenia in the coronary care unit</title><author>PATNODE, Nicole M ; GANDHI, Pritesh J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-3467a554b07d8def0968078e745894803a4ce3d82599929654e22379c44cc6c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Anticoagulants - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Coronary Care Units</topic><topic>Diagnosis, Differential</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Fibrinolytic Agents - adverse effects</topic><topic>Heparin - adverse effects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. 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| identifier | ISSN: 0929-5305 |
| ispartof | Journal of thrombosis and thrombolysis, 2000-10, Vol.10 (2), p.155-167 |
| issn | 0929-5305 1573-742X |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Anticoagulants - adverse effects Biological and medical sciences Coronary Care Units Diagnosis, Differential Drug toxicity and drugs side effects treatment Fibrinolytic Agents - adverse effects Heparin - adverse effects Humans Medical sciences Pharmacology. Drug treatments Platelet Aggregation Inhibitors - adverse effects Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors Thrombocytopenia - chemically induced Thrombocytopenia - complications Thrombocytopenia - etiology Ticlopidine - adverse effects Toxicity: blood |
| title | Drug-induced thrombocytopenia in the coronary care unit |
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