Trousseau's syndrome treated with long-term subcutaneous lepirudin (case report and review of the literature)
We report here a case of recurrent venous and arterial thromboembolism, Trousseau's syndrome, in a cancer patient who developed heparin-induced thrombocytopenia. She was treated with lepirudin and after establishing the patient-specific half-life for subcutaneous lepirudin, she was successfully...
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| Veröffentlicht in: | Journal of thrombosis and thrombolysis 2001-02, Vol.11 (1), p.33-37 |
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| container_end_page | 37 |
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| container_title | Journal of thrombosis and thrombolysis |
| container_volume | 11 |
| creator | ANDREESCU, Astrid C. M CUSHMAN, Mary HAMMOND, Julia M WOOD, Marie E |
| description | We report here a case of recurrent venous and arterial thromboembolism, Trousseau's syndrome, in a cancer patient who developed heparin-induced thrombocytopenia. She was treated with lepirudin and after establishing the patient-specific half-life for subcutaneous lepirudin, she was successfully maintained on this therapy for more than eight months. To our knowledge this case represents the longest reported use of subcutaneous lepirudin. |
| doi_str_mv | 10.1023/A:1008952126124 |
| format | Article |
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Drug treatments</subject><subject>Recombinant Proteins - administration & dosage</subject><subject>Recurrence</subject><subject>Thrombocytopenia - chemically induced</subject><subject>Thromboembolism - drug therapy</subject><subject>Thromboembolism - etiology</subject><subject>Venous Thrombosis - drug therapy</subject><subject>Venous Thrombosis - etiology</subject><issn>0929-5305</issn><issn>1573-742X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNo90ElLw0AUAOBBFFurZ28y6EE9RGeLyXgrxQ0KXip4C6-ZF5uSzVks_feOWD29d_jeSsgpZzecCXk7veeM5ToVXNxxofbImKeZTDIl3vfJmGmhk1SydESOnFszxrRm4pCMeLR5ludj0i5sH5xDCJeOum1nbN8i9RbBo6Gb2q9o03cfiUfbUheWZfDQYSyhDQ61Dabu6FUJDqnFobeeQmdi-lXjhvYV9SukTR2LwQeL18fkoILG4ckuTsjb48Ni9pzMX59eZtN5UkqW-yQrTdwaAFFLg1UWb-RY6gz4HXCoEDjLU4NS4VJAyoQoZTRVBVmlOIKWE3L-23ew_WdA54t1H2wXRxZCMMmUUj_obIfCskVTDLZuwW6Lv-dEcLED4EpoKgtdWbt_p4VKY7NvzvF0zQ</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>ANDREESCU, Astrid C. 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Reticuloendothelial system</topic><topic>Female</topic><topic>Heparin - adverse effects</topic><topic>Hirudins - administration & dosage</topic><topic>Hirudins - analogs & derivatives</topic><topic>Humans</topic><topic>Injections, Subcutaneous</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Paraneoplastic Syndromes - drug therapy</topic><topic>Partial Thromboplastin Time</topic><topic>Pharmacology. Drug treatments</topic><topic>Recombinant Proteins - administration & dosage</topic><topic>Recurrence</topic><topic>Thrombocytopenia - chemically induced</topic><topic>Thromboembolism - drug therapy</topic><topic>Thromboembolism - etiology</topic><topic>Venous Thrombosis - drug therapy</topic><topic>Venous Thrombosis - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ANDREESCU, Astrid C. 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M</au><au>CUSHMAN, Mary</au><au>HAMMOND, Julia M</au><au>WOOD, Marie E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trousseau's syndrome treated with long-term subcutaneous lepirudin (case report and review of the literature)</atitle><jtitle>Journal of thrombosis and thrombolysis</jtitle><addtitle>J Thromb Thrombolysis</addtitle><date>2001-02-01</date><risdate>2001</risdate><volume>11</volume><issue>1</issue><spage>33</spage><epage>37</epage><pages>33-37</pages><issn>0929-5305</issn><eissn>1573-742X</eissn><coden>JTTHFF</coden><abstract>We report here a case of recurrent venous and arterial thromboembolism, Trousseau's syndrome, in a cancer patient who developed heparin-induced thrombocytopenia. She was treated with lepirudin and after establishing the patient-specific half-life for subcutaneous lepirudin, she was successfully maintained on this therapy for more than eight months. 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| ispartof | Journal of thrombosis and thrombolysis, 2001-02, Vol.11 (1), p.33-37 |
| issn | 0929-5305 1573-742X |
| language | eng |
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| subjects | Anticoagulants - administration & dosage Arterial Occlusive Diseases - drug therapy Arterial Occlusive Diseases - etiology Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Female Heparin - adverse effects Hirudins - administration & dosage Hirudins - analogs & derivatives Humans Injections, Subcutaneous Kinetics Medical sciences Middle Aged Paraneoplastic Syndromes - drug therapy Partial Thromboplastin Time Pharmacology. Drug treatments Recombinant Proteins - administration & dosage Recurrence Thrombocytopenia - chemically induced Thromboembolism - drug therapy Thromboembolism - etiology Venous Thrombosis - drug therapy Venous Thrombosis - etiology |
| title | Trousseau's syndrome treated with long-term subcutaneous lepirudin (case report and review of the literature) |
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