UBD, a downstream element of FOXP3, allows the identification of LGALS3, a new marker of human regulatory T cells

Here, we report the identification of the ubiquitin-like gene UBD as a downstream element of FOXP3 in human activated regulatory CD4+CD25hi T cells (Treg). Retroviral transduction of UBD in human allo-reactive effector CD4+ T helper (Th) cells upregulates CD25 and mediates downregulation of IL4 and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Laboratory investigation 2006-07, Vol.86 (7), p.724-737
Hauptverfasser:	Ocklenburg, Frank, Moharregh-Khiabani, Darius, Geffers, Robert, Janke, Viktoria, Pfoertner, Susanne, Garritsen, Henk, Groebe, Lothar, Klempnauer, Juergen, Dittmar, Kurt E J, Weiss, Siegfried, Buer, Jan, Probst-Kepper, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers - metabolism Biotechnology Calcium - metabolism CD4 Antigens - immunology CD4+CD25hi Cell Proliferation Cells, Cultured CTLA4 Forkhead Transcription Factors - genetics Forkhead Transcription Factors - immunology FOXP3 Fundamental and applied biological sciences. Psychology Galectin 3 - genetics Galectin 3 - immunology Gene Expression Regulation - drug effects Humans Interleukin-4 - immunology Interleukin-4 - metabolism Interleukin-5 - immunology Interleukin-5 - metabolism Investigative techniques, diagnostic techniques (general aspects) Ionomycin - pharmacology Ionophores - pharmacology LGALS3 Medical sciences Receptors, Interleukin-1 - biosynthesis Receptors, Interleukin-1 Type II Receptors, Interleukin-2 - immunology regulatory T cells Retroviridae - genetics T-Lymphocyte Subsets - immunology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Transduction, Genetic UBD Ubiquitins - genetics Ubiquitins - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!