Synthesis of 5-Methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one in Supercritical Carbon Dioxide
5-Methyl-1,2,4-triazolo[1,5- a ]pyrimidin-7(4 H )-one, an intermediate product in the synthesis of the antiviral drug Triazid®, was obtained for the first time by condensation of 3 H -1,2,4-triazol-5-amine with ethyl acetoacetate in the presence of a catalytic amount of ZnCl 2 in supercritical carbo...
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| Veröffentlicht in: | Russian journal of general chemistry 2019, Vol.89 (1), p.151-152 |
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| container_title | Russian journal of general chemistry |
| container_volume | 89 |
| creator | Baklykov, A. V. Rusinov, G. L. Rusinov, V. L. Charushin, V. N. Kopchuk, D. S. Zyryanov, G. V. Artem’ev, G. A. |
| description | 5-Methyl-1,2,4-triazolo[1,5-
a
]pyrimidin-7(4
H
)-one, an intermediate product in the synthesis of the antiviral drug Triazid®, was obtained for the first time by condensation of 3
H
-1,2,4-triazol-5-amine with ethyl acetoacetate in the presence of a catalytic amount of ZnCl
2
in supercritical carbon dioxide (200 bar) under solvent-free conditions. Depending on the temperature and reaction time, the conversion was 90%. |
| doi_str_mv | 10.1134/S1070363219010274 |
| format | Article |
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a
]pyrimidin-7(4
H
)-one, an intermediate product in the synthesis of the antiviral drug Triazid®, was obtained for the first time by condensation of 3
H
-1,2,4-triazol-5-amine with ethyl acetoacetate in the presence of a catalytic amount of ZnCl
2
in supercritical carbon dioxide (200 bar) under solvent-free conditions. Depending on the temperature and reaction time, the conversion was 90%.</description><identifier>ISSN: 1070-3632</identifier><identifier>EISSN: 1608-3350</identifier><identifier>DOI: 10.1134/S1070363219010274</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Antiviral agents ; Carbon dioxide ; Catalysis ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Condensates ; Letters to the Editor ; Production processes ; Reaction time ; Synthesis ; Zinc chloride</subject><ispartof>Russian journal of general chemistry, 2019, Vol.89 (1), p.151-152</ispartof><rights>Pleiades Publishing, Ltd. 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Copyright Springer Nature B.V. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-f8060fbcb5966f71d1e44af8ac0826de7abde08503479345b32f474bb64e10fc3</citedby><cites>FETCH-LOGICAL-c383t-f8060fbcb5966f71d1e44af8ac0826de7abde08503479345b32f474bb64e10fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1070363219010274$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1070363219010274$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Baklykov, A. V.</creatorcontrib><creatorcontrib>Rusinov, G. L.</creatorcontrib><creatorcontrib>Rusinov, V. L.</creatorcontrib><creatorcontrib>Charushin, V. N.</creatorcontrib><creatorcontrib>Kopchuk, D. S.</creatorcontrib><creatorcontrib>Zyryanov, G. V.</creatorcontrib><creatorcontrib>Artem’ev, G. A.</creatorcontrib><title>Synthesis of 5-Methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one in Supercritical Carbon Dioxide</title><title>Russian journal of general chemistry</title><addtitle>Russ J Gen Chem</addtitle><description>5-Methyl-1,2,4-triazolo[1,5-
a
]pyrimidin-7(4
H
)-one, an intermediate product in the synthesis of the antiviral drug Triazid®, was obtained for the first time by condensation of 3
H
-1,2,4-triazol-5-amine with ethyl acetoacetate in the presence of a catalytic amount of ZnCl
2
in supercritical carbon dioxide (200 bar) under solvent-free conditions. Depending on the temperature and reaction time, the conversion was 90%.</description><subject>Antiviral agents</subject><subject>Carbon dioxide</subject><subject>Catalysis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Condensates</subject><subject>Letters to the Editor</subject><subject>Production processes</subject><subject>Reaction time</subject><subject>Synthesis</subject><subject>Zinc chloride</subject><issn>1070-3632</issn><issn>1608-3350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kUtLAzEQgBdRsFZ_gLcFLwpNnTw22R5LfVRQPFRPoks2m7Qp201NtmD99aZUKKKSw4TM902SmSQ5xdDHmLLLCQYBlFOCB4CBCLaXdDCHHFGawX7cxzTa5A-ToxDmECHgpJO8TdZNO9PBhtSZNEMPup2ta4R7pMdQ6638dLV7wb0Mydfl2tuFrWyDxDkbXyDX6NQ26WS11F5521ol63Qkfema9Mq6D1vp4-TAyDrok-_YTZ5vrp9GY3T_eHs3Gt4jRXPaIpMDB1OqMhtwbgSusGZMmlwqyAmvtJBlpSHPgDIxoCwrKTFMsLLkTGMwinaTs23dpXfvKx3aYu5WvolXFoQAYURwzHbUVNa6sI1xrZdqYYMqhoKIyOVkEKn-H1RclV5YFT9tbDz_IeCtoLwLwWtTLGOjpF8XGIrNdIpf04kO2Tohss1U-92D_5e-AFI7jNE</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Baklykov, A. V.</creator><creator>Rusinov, G. L.</creator><creator>Rusinov, V. L.</creator><creator>Charushin, V. N.</creator><creator>Kopchuk, D. S.</creator><creator>Zyryanov, G. V.</creator><creator>Artem’ev, G. A.</creator><general>Pleiades Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2019</creationdate><title>Synthesis of 5-Methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one in Supercritical Carbon Dioxide</title><author>Baklykov, A. V. ; Rusinov, G. L. ; Rusinov, V. L. ; Charushin, V. N. ; Kopchuk, D. S. ; Zyryanov, G. V. ; Artem’ev, G. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-f8060fbcb5966f71d1e44af8ac0826de7abde08503479345b32f474bb64e10fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antiviral agents</topic><topic>Carbon dioxide</topic><topic>Catalysis</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Condensates</topic><topic>Letters to the Editor</topic><topic>Production processes</topic><topic>Reaction time</topic><topic>Synthesis</topic><topic>Zinc chloride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baklykov, A. V.</creatorcontrib><creatorcontrib>Rusinov, G. L.</creatorcontrib><creatorcontrib>Rusinov, V. L.</creatorcontrib><creatorcontrib>Charushin, V. N.</creatorcontrib><creatorcontrib>Kopchuk, D. S.</creatorcontrib><creatorcontrib>Zyryanov, G. V.</creatorcontrib><creatorcontrib>Artem’ev, G. A.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of general chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baklykov, A. V.</au><au>Rusinov, G. L.</au><au>Rusinov, V. L.</au><au>Charushin, V. N.</au><au>Kopchuk, D. S.</au><au>Zyryanov, G. V.</au><au>Artem’ev, G. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of 5-Methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one in Supercritical Carbon Dioxide</atitle><jtitle>Russian journal of general chemistry</jtitle><stitle>Russ J Gen Chem</stitle><date>2019</date><risdate>2019</risdate><volume>89</volume><issue>1</issue><spage>151</spage><epage>152</epage><pages>151-152</pages><issn>1070-3632</issn><eissn>1608-3350</eissn><abstract>5-Methyl-1,2,4-triazolo[1,5-
a
]pyrimidin-7(4
H
)-one, an intermediate product in the synthesis of the antiviral drug Triazid®, was obtained for the first time by condensation of 3
H
-1,2,4-triazol-5-amine with ethyl acetoacetate in the presence of a catalytic amount of ZnCl
2
in supercritical carbon dioxide (200 bar) under solvent-free conditions. Depending on the temperature and reaction time, the conversion was 90%.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1070363219010274</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1070-3632 |
| ispartof | Russian journal of general chemistry, 2019, Vol.89 (1), p.151-152 |
| issn | 1070-3632 1608-3350 |
| language | eng |
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| source | Springer Online Journals Complete |
| subjects | Antiviral agents Carbon dioxide Catalysis Chemistry Chemistry and Materials Science Chemistry/Food Science Condensates Letters to the Editor Production processes Reaction time Synthesis Zinc chloride |
| title | Synthesis of 5-Methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one in Supercritical Carbon Dioxide |
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