Vimentin is secreted by activated macrophages

Vimentin is a widely expressed intermediate filament protein thought to be involved mainly in structural processes, such as wound healing 1 . We now demonstrate that activated human macrophages secrete vimentin into the extracellular space. The maturation of blood-derived monocytes into macrophages...

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Veröffentlicht in:	Nature cell biology 2003-01, Vol.5 (1), p.59-63
Hauptverfasser:	Mor-Vaknin, Nirit, Punturieri, Antonello, Sitwala, Kajal, Markovitz, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Blood Cancer Research Cell Biology Cells, Cultured Cellular proteins Cytokines Developmental Biology Enzyme Inhibitors - pharmacology Humans Immune response Immunohistochemistry Interleukin-10 - pharmacology Internal medicine Kinases Kinetics Labeling letter Life Sciences Localization Macrophage Activation - physiology Macrophages Macrophages - cytology Macrophages - drug effects Macrophages - secretion Medical research Metabolites Monocytes - cytology Okadaic Acid - pharmacology Phosphatase Phosphorylation Physiological aspects Protein Kinase C - antagonists & inhibitors Proteins Signal Transduction Stem Cells Tumor necrosis factor-TNF Vimentin - antagonists & inhibitors Vimentin - secretion
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