N-in-one permeability studies of heterogeneous sets of compounds across Caco-2 cell monolayers

The purpose of the study was to evaluate several n-in-one cocktails of heterogeneous compounds to increase the throughput of permeability studies across Caco-2 monolayers, to investigate the reliability and applicability of the method, and to develop fast and sensitive analysis for the compounds. Co...

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Veröffentlicht in:	Pharmaceutical research 2003-02, Vol.20 (2), p.187-197
Hauptverfasser:	LAITINEN, Leena, KANGAS, Heli, KAUKONEN, Ann Marie, HAKALA, Kati, KOTIAHO, Tapio, KOSTIAINEN, Risto, HIRVONEN, Jouni
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Biological and medical sciences Biological Transport - physiology Caco-2 Cells - metabolism Chromatography Experiments General pharmacology Glycoproteins Humans Mass spectrometry Medical sciences Permeability Pharmaceutical Preparations - analysis Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Scientific imaging Small intestine Spectrometry, Mass, Electrospray Ionization - methods Toxicity
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