NTA and Fe(III)NTA: differential patterns of renal toxicity in subchronic studies

Differential patterns in terms of nephropathology and 8-hydroxyguanine formation in the course of oral 28-day studies were observed with nitrilotriacetic acid (NTA) and FeNTA. FeNTA, but not NTA, caused enhanced 8-hydroxyguanine formation in kidney DNA after oral and intraperitoneal administration....

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Veröffentlicht in:	Human & experimental toxicology 2002-08, Vol.21 (8), p.445-452
Hauptverfasser:	Leibold, E, Deckardt, K, Mellert, W, Potthoff-Karl, B, Grundler, O, Jäckh, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Administration, Oral Animals Chelating Agents - administration & dosage Chelating Agents - toxicity Cytotoxicity DNA - chemistry Enzymes Ferric Compounds - administration & dosage Ferric Compounds - toxicity Guanine - analogs & derivatives Guanine - analysis Infusions, Parenteral Kidney - pathology Kidneys Lipid Peroxidation Lipids Male Nitrilotriacetic Acid - administration & dosage Nitrilotriacetic Acid - analogs & derivatives Nitrilotriacetic Acid - toxicity Oral administration Product safety Rats Rats, Wistar Sodium Thermodynamics Toxicity Toxicology Tumors Zinc - pharmacology
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