Severe, Acute Liver Injury and Khat Leaves
To the Editor: The chewing of khat leaves ( Catha edulis ) is a widespread recreational custom in East Africa and the Arabian Peninsula. The plant contains the alkaloids cathine and cathinone, which have amphetamine-like properties and produce a variety of pleasurable effects. Khat is banned in the...
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| Veröffentlicht in: | The New England journal of medicine 2010-04, Vol.362 (17), p.1642-1644 |
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| container_issue | 17 |
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| container_title | The New England journal of medicine |
| container_volume | 362 |
| creator | Chapman, Michael H Borges, Gina Crozier, Alan Morgan, Marsha Y O'Beirne, James Patch, David Kajihara, Mikio Dhillon, Amar P |
| description | To the Editor:
The chewing of khat leaves (
Catha edulis
) is a widespread recreational custom in East Africa and the Arabian Peninsula. The plant contains the alkaloids cathine and cathinone, which have amphetamine-like properties and produce a variety of pleasurable effects. Khat is banned in the United States, but large quantities are nonetheless exported to North America from the United Kingdom, where it is freely available and used widely by immigrant populations. The detrimental personal and social effects of khat are well recognized.
1
Both psychiatric illness
2
and cardiovascular disease
3
have been recorded. We report the results of our . . . |
| doi_str_mv | 10.1056/NEJMc0908038 |
| format | Article |
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The chewing of khat leaves (
Catha edulis
) is a widespread recreational custom in East Africa and the Arabian Peninsula. The plant contains the alkaloids cathine and cathinone, which have amphetamine-like properties and produce a variety of pleasurable effects. Khat is banned in the United States, but large quantities are nonetheless exported to North America from the United Kingdom, where it is freely available and used widely by immigrant populations. The detrimental personal and social effects of khat are well recognized.
1
Both psychiatric illness
2
and cardiovascular disease
3
have been recorded. We report the results of our . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMc0908038</identifier><identifier>PMID: 20427816</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Acute Disease ; Adult ; Catha - adverse effects ; Colleges & universities ; Fatal Outcome ; Female ; Hepatitis - etiology ; Humans ; Liver cirrhosis ; Liver Transplantation ; Male ; Plant Leaves ; University colleges</subject><ispartof>The New England journal of medicine, 2010-04, Vol.362 (17), p.1642-1644</ispartof><rights>Copyright © 2010 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-176d9ff9185d5649f279c2c3f2d14d5d9794b4b878abda9863b66a01f8f245113</citedby><cites>FETCH-LOGICAL-c352t-176d9ff9185d5649f279c2c3f2d14d5d9794b4b878abda9863b66a01f8f245113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMc0908038$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/220099522?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2759,2760,26103,27924,27925,52382,54064,64385,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20427816$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chapman, Michael H</creatorcontrib><creatorcontrib>Borges, Gina</creatorcontrib><creatorcontrib>Crozier, Alan</creatorcontrib><creatorcontrib>Morgan, Marsha Y</creatorcontrib><creatorcontrib>O'Beirne, James</creatorcontrib><creatorcontrib>Patch, David</creatorcontrib><creatorcontrib>Kajihara, Mikio</creatorcontrib><creatorcontrib>Dhillon, Amar P</creatorcontrib><title>Severe, Acute Liver Injury and Khat Leaves</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
The chewing of khat leaves (
Catha edulis
) is a widespread recreational custom in East Africa and the Arabian Peninsula. The plant contains the alkaloids cathine and cathinone, which have amphetamine-like properties and produce a variety of pleasurable effects. Khat is banned in the United States, but large quantities are nonetheless exported to North America from the United Kingdom, where it is freely available and used widely by immigrant populations. The detrimental personal and social effects of khat are well recognized.
1
Both psychiatric illness
2
and cardiovascular disease
3
have been recorded. We report the results of our . . .</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Catha - adverse effects</subject><subject>Colleges & universities</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Hepatitis - etiology</subject><subject>Humans</subject><subject>Liver cirrhosis</subject><subject>Liver Transplantation</subject><subject>Male</subject><subject>Plant Leaves</subject><subject>University colleges</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkM9LwzAUgIMobk5vnqWIJ1n15WeT4xhTp1UP6jmkTYIrtptJO9h_b2VTPPgujwcf34MPoVMMVxi4uH6a3T-WoEAClXtoiDmlKWMg9tEQgMiUZYoO0FGMFfSDmTpEAwKMZBKLIbp8cWsX3DiZlF3rknzRX8m8qbqwSUxjk4d30ya5M2sXj9GBNx_Rnez2CL3dzF6nd2n-fDufTvK0pJy0Kc6EVd4rLLnlgilPMlWSknpiMbPcqkyxghUyk6awRklBCyEMYC89YRxjOkLnW-8qLD87F1tdLbvQ9C81IQBKcUJ6aLyFyrCMMTivV2FRm7DRGPR3F_23S4-f7ZxdUTv7C_-E6IGLLVDXUTeuqv_3fAEhNWTz</recordid><startdate>20100429</startdate><enddate>20100429</enddate><creator>Chapman, Michael H</creator><creator>Borges, Gina</creator><creator>Crozier, Alan</creator><creator>Morgan, Marsha Y</creator><creator>O'Beirne, James</creator><creator>Patch, David</creator><creator>Kajihara, Mikio</creator><creator>Dhillon, Amar P</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20100429</creationdate><title>Severe, Acute Liver Injury and Khat Leaves</title><author>Chapman, Michael H ; Borges, Gina ; Crozier, Alan ; Morgan, Marsha Y ; O'Beirne, James ; Patch, David ; Kajihara, Mikio ; Dhillon, Amar P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-176d9ff9185d5649f279c2c3f2d14d5d9794b4b878abda9863b66a01f8f245113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Catha - adverse effects</topic><topic>Colleges & universities</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Hepatitis - etiology</topic><topic>Humans</topic><topic>Liver cirrhosis</topic><topic>Liver Transplantation</topic><topic>Male</topic><topic>Plant Leaves</topic><topic>University colleges</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chapman, Michael H</creatorcontrib><creatorcontrib>Borges, Gina</creatorcontrib><creatorcontrib>Crozier, Alan</creatorcontrib><creatorcontrib>Morgan, Marsha Y</creatorcontrib><creatorcontrib>O'Beirne, James</creatorcontrib><creatorcontrib>Patch, David</creatorcontrib><creatorcontrib>Kajihara, Mikio</creatorcontrib><creatorcontrib>Dhillon, Amar P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chapman, Michael H</au><au>Borges, Gina</au><au>Crozier, Alan</au><au>Morgan, Marsha Y</au><au>O'Beirne, James</au><au>Patch, David</au><au>Kajihara, Mikio</au><au>Dhillon, Amar P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Severe, Acute Liver Injury and Khat Leaves</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2010-04-29</date><risdate>2010</risdate><volume>362</volume><issue>17</issue><spage>1642</spage><epage>1644</epage><pages>1642-1644</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>To the Editor:
The chewing of khat leaves (
Catha edulis
) is a widespread recreational custom in East Africa and the Arabian Peninsula. The plant contains the alkaloids cathine and cathinone, which have amphetamine-like properties and produce a variety of pleasurable effects. Khat is banned in the United States, but large quantities are nonetheless exported to North America from the United Kingdom, where it is freely available and used widely by immigrant populations. The detrimental personal and social effects of khat are well recognized.
1
Both psychiatric illness
2
and cardiovascular disease
3
have been recorded. We report the results of our . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>20427816</pmid><doi>10.1056/NEJMc0908038</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2010-04, Vol.362 (17), p.1642-1644 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_journals_220099522 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Acute Disease Adult Catha - adverse effects Colleges & universities Fatal Outcome Female Hepatitis - etiology Humans Liver cirrhosis Liver Transplantation Male Plant Leaves University colleges |
| title | Severe, Acute Liver Injury and Khat Leaves |
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