Longitudinal multi-level biomarker analysis of BDNF in major depression and bipolar disorder
Preliminary evidence suggests that BDNF (brain derived neurotrophic factor) rs6265 genetic polymorphism, BDNF gene promotor methylation and BDNF serum levels might play an important role in the pathogenesis of affective disorders. As studies testing the BDNF system across molecular levels are sparse...
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| Veröffentlicht in: | European archives of psychiatry and clinical neuroscience 2020-03, Vol.270 (2), p.169-181 |
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| creator | Schröter, Katrin Brum, Murielle Brunkhorst-Kanaan, Nathalie Tole, Franziska Ziegler, Christiane Domschke, Katharina Reif, Andreas Kittel-Schneider, Sarah |
| description | Preliminary evidence suggests that
BDNF
(brain derived neurotrophic factor) rs6265 genetic polymorphism,
BDNF
gene promotor methylation and BDNF serum levels might play an important role in the pathogenesis of affective disorders. As studies testing the BDNF system across molecular levels are sparse, this study aimed at investigating the
BDNF
val66met genotype,
BDNF
DNA methylation changes and peripheral BDNF serum levels in acute and remitted phases of MDD (major depressive disorder) and BD (bipolar disorder) and healthy controls. We found a significant difference of methylation levels at CpG site 1-1-1 and 3-1-1 between MDD and healthy controls (
p
|
| doi_str_mv | 10.1007/s00406-019-01007-y |
| format | Article |
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BDNF
(brain derived neurotrophic factor) rs6265 genetic polymorphism,
BDNF
gene promotor methylation and BDNF serum levels might play an important role in the pathogenesis of affective disorders. As studies testing the BDNF system across molecular levels are sparse, this study aimed at investigating the
BDNF
val66met genotype,
BDNF
DNA methylation changes and peripheral BDNF serum levels in acute and remitted phases of MDD (major depressive disorder) and BD (bipolar disorder) and healthy controls. We found a significant difference of methylation levels at CpG site 1-1-1 and 3-1-1 between MDD and healthy controls (
p
< 0.003) with MDD patients showing significantly higher methylation levels. CpG 5-2-1 revealed a statistically significant difference between MDD and healthy controls and MDD and BD (
p
= 0.00003). Similar to the results of the methylation analysis a significant difference between MDD and healthy controls was found in BDNF serum levels (
p
= 0.002) with significantly lower BDNF serum levels in MDD compared to healthy controls. A difference between the samples from admission and discharge from hospital of both
BDNF
gene methylation and serum levels could not be detected in the present study and no influence of the
BDNF
val66met genotype on neither methylation nor BDNF serum level.</description><identifier>ISSN: 0940-1334</identifier><identifier>EISSN: 1433-8491</identifier><identifier>DOI: 10.1007/s00406-019-01007-y</identifier><identifier>PMID: 30929061</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Affective disorders ; Biomarkers ; Bipolar disorder ; Brain-derived neurotrophic factor ; CpG islands ; DNA methylation ; Gene polymorphism ; Medicine ; Medicine & Public Health ; Mental depression ; Neurosciences ; Original Paper ; Psychiatry ; Serum levels ; Statistical analysis</subject><ispartof>European archives of psychiatry and clinical neuroscience, 2020-03, Vol.270 (2), p.169-181</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>European Archives of Psychiatry and Clinical Neuroscience is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p180t-a842506b2550d8af8f7889a82e61722645c826608a26b32ef24f0d0ded0cb2983</cites><orcidid>0000-0003-3057-6150</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00406-019-01007-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00406-019-01007-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30929061$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schröter, Katrin</creatorcontrib><creatorcontrib>Brum, Murielle</creatorcontrib><creatorcontrib>Brunkhorst-Kanaan, Nathalie</creatorcontrib><creatorcontrib>Tole, Franziska</creatorcontrib><creatorcontrib>Ziegler, Christiane</creatorcontrib><creatorcontrib>Domschke, Katharina</creatorcontrib><creatorcontrib>Reif, Andreas</creatorcontrib><creatorcontrib>Kittel-Schneider, Sarah</creatorcontrib><title>Longitudinal multi-level biomarker analysis of BDNF in major depression and bipolar disorder</title><title>European archives of psychiatry and clinical neuroscience</title><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><description>Preliminary evidence suggests that
BDNF
(brain derived neurotrophic factor) rs6265 genetic polymorphism,
BDNF
gene promotor methylation and BDNF serum levels might play an important role in the pathogenesis of affective disorders. As studies testing the BDNF system across molecular levels are sparse, this study aimed at investigating the
BDNF
val66met genotype,
BDNF
DNA methylation changes and peripheral BDNF serum levels in acute and remitted phases of MDD (major depressive disorder) and BD (bipolar disorder) and healthy controls. We found a significant difference of methylation levels at CpG site 1-1-1 and 3-1-1 between MDD and healthy controls (
p
< 0.003) with MDD patients showing significantly higher methylation levels. CpG 5-2-1 revealed a statistically significant difference between MDD and healthy controls and MDD and BD (
p
= 0.00003). Similar to the results of the methylation analysis a significant difference between MDD and healthy controls was found in BDNF serum levels (
p
= 0.002) with significantly lower BDNF serum levels in MDD compared to healthy controls. A difference between the samples from admission and discharge from hospital of both
BDNF
gene methylation and serum levels could not be detected in the present study and no influence of the
BDNF
val66met genotype on neither methylation nor BDNF serum level.</description><subject>Affective disorders</subject><subject>Biomarkers</subject><subject>Bipolar disorder</subject><subject>Brain-derived neurotrophic factor</subject><subject>CpG islands</subject><subject>DNA methylation</subject><subject>Gene polymorphism</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental depression</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Psychiatry</subject><subject>Serum levels</subject><subject>Statistical analysis</subject><issn>0940-1334</issn><issn>1433-8491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpFkE1PwzAMQCMEYmPwBzigSpwDzkfT9AiDAdIEF7ghRemSThldU5IWqf-ewIY4WJbsZ8t-CJ0TuCIAxXUE4CAwkDJFKuDxAE0JZwxLXpJDNIWSAyaM8Qk6iXEDACSncIwmDEpagiBT9L707dr1g3GtbrLt0PQON_bLNlnl_FaHDxsynVpjdDHzdXZ797zIXJtt9caHzNgu2BidbxNk0kjnG53KLvpgbDhFR7Vuoj3b5xl6W9y_zh_x8uXhaX6zxB2R0GMtOc1BVDTPwUhdy7qQstSSWkEKSgXPV5IKAVJTUTFqa8prMGCsgVVFS8lm6HK3twv-c7CxVxs_hHR1VJSmr2UheJGoiz01VFtrVBdcenBUfzISwHZATK12bcP_GgLqx7DaKVdJufpVrkb2DfopcRk</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Schröter, Katrin</creator><creator>Brum, Murielle</creator><creator>Brunkhorst-Kanaan, Nathalie</creator><creator>Tole, Franziska</creator><creator>Ziegler, Christiane</creator><creator>Domschke, Katharina</creator><creator>Reif, Andreas</creator><creator>Kittel-Schneider, Sarah</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0003-3057-6150</orcidid></search><sort><creationdate>20200301</creationdate><title>Longitudinal multi-level biomarker analysis of BDNF in major depression and bipolar disorder</title><author>Schröter, Katrin ; Brum, Murielle ; Brunkhorst-Kanaan, Nathalie ; Tole, Franziska ; Ziegler, Christiane ; Domschke, Katharina ; Reif, Andreas ; Kittel-Schneider, Sarah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p180t-a842506b2550d8af8f7889a82e61722645c826608a26b32ef24f0d0ded0cb2983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Affective disorders</topic><topic>Biomarkers</topic><topic>Bipolar disorder</topic><topic>Brain-derived neurotrophic factor</topic><topic>CpG islands</topic><topic>DNA methylation</topic><topic>Gene polymorphism</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental depression</topic><topic>Neurosciences</topic><topic>Original Paper</topic><topic>Psychiatry</topic><topic>Serum levels</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schröter, Katrin</creatorcontrib><creatorcontrib>Brum, Murielle</creatorcontrib><creatorcontrib>Brunkhorst-Kanaan, Nathalie</creatorcontrib><creatorcontrib>Tole, Franziska</creatorcontrib><creatorcontrib>Ziegler, Christiane</creatorcontrib><creatorcontrib>Domschke, Katharina</creatorcontrib><creatorcontrib>Reif, Andreas</creatorcontrib><creatorcontrib>Kittel-Schneider, Sarah</creatorcontrib><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>European archives of psychiatry and clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schröter, Katrin</au><au>Brum, Murielle</au><au>Brunkhorst-Kanaan, Nathalie</au><au>Tole, Franziska</au><au>Ziegler, Christiane</au><au>Domschke, Katharina</au><au>Reif, Andreas</au><au>Kittel-Schneider, Sarah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal multi-level biomarker analysis of BDNF in major depression and bipolar disorder</atitle><jtitle>European archives of psychiatry and clinical neuroscience</jtitle><stitle>Eur Arch Psychiatry Clin Neurosci</stitle><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>270</volume><issue>2</issue><spage>169</spage><epage>181</epage><pages>169-181</pages><issn>0940-1334</issn><eissn>1433-8491</eissn><abstract>Preliminary evidence suggests that
BDNF
(brain derived neurotrophic factor) rs6265 genetic polymorphism,
BDNF
gene promotor methylation and BDNF serum levels might play an important role in the pathogenesis of affective disorders. As studies testing the BDNF system across molecular levels are sparse, this study aimed at investigating the
BDNF
val66met genotype,
BDNF
DNA methylation changes and peripheral BDNF serum levels in acute and remitted phases of MDD (major depressive disorder) and BD (bipolar disorder) and healthy controls. We found a significant difference of methylation levels at CpG site 1-1-1 and 3-1-1 between MDD and healthy controls (
p
< 0.003) with MDD patients showing significantly higher methylation levels. CpG 5-2-1 revealed a statistically significant difference between MDD and healthy controls and MDD and BD (
p
= 0.00003). Similar to the results of the methylation analysis a significant difference between MDD and healthy controls was found in BDNF serum levels (
p
= 0.002) with significantly lower BDNF serum levels in MDD compared to healthy controls. A difference between the samples from admission and discharge from hospital of both
BDNF
gene methylation and serum levels could not be detected in the present study and no influence of the
BDNF
val66met genotype on neither methylation nor BDNF serum level.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30929061</pmid><doi>10.1007/s00406-019-01007-y</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-3057-6150</orcidid></addata></record> |
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| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Affective disorders Biomarkers Bipolar disorder Brain-derived neurotrophic factor CpG islands DNA methylation Gene polymorphism Medicine Medicine & Public Health Mental depression Neurosciences Original Paper Psychiatry Serum levels Statistical analysis |
| title | Longitudinal multi-level biomarker analysis of BDNF in major depression and bipolar disorder |
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